Arabian Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
17(2), P. 105591 - 105591
Published: Dec. 26, 2023
Ziziphi
Spinosae
Folium,
the
leaf
of
Ziziphus
jujuba
Mill.
var.
spinosa
(Bunge)
Hu
ex
H.
F.
Chou
(LZJS),
was
widely
distributed
in
northern
China.
Our
previous
study
showed
that
LZJS
flavonoid
(LZJSF)
exerted
antioxidant
activity
at
chemical
and
PC12
cell
levels,
respectively.
Here,
we
further
studied
function
LZJSF
on
aging-related
oxidative
stress
D-galactose
(D-gal)-induced
rats
potential
mechanisms
were
explored.
The
aging
model
established
by
intraperitoneal
injection
D-gal
(300
mg·kg-1·day-1)
for
36
days,
low-dose
(LLZJSF
100
high-dose
(HLZJSF,
200
administered
daily
oral
gavage
same
time,
Their
spatial
learning
memory
abilities
evaluated
Morris
water
maze
test.
HLZJSF
observed
to
significantly
ameliorate
cognitive
ability
indexes,
such
as
reduction
MDA
augmentation
SOD,
GSH-Px,
T-AOC
CAT,
effect
these
indexes
stronger
than
LLZJSF.
A
precise
well-defined
research
strategy
successfully
applied
screen
serum
differential
metabolites.
Furthermore,
integrated
urine
metabolomics
derivations
nine
significant
metabolites
could
be
regulated
administration
HLZJSF,
which
suggested
intervention
against
may
involve
amino
acid
metabolism
including
D-Glutamine
D-glutamate,
alanine,
aspartate
glutamate,
arginine
proline
biosynthesis.
16S
rRNA
sequencing
analysis
descend
relative
abundance
Firmicutes
Actinobacteria,
well
ratio
Firmicutes/Bacteroidetes,
increase
Bacteroidetes
Proteobacteria.
Finally,
correlation
beneficial
effects
resulted
from
regulation
disturbance
gut
microbiota
through
"microbiota-gut-brain"
axis
affect
regulate
stress.
This
will
provide
a
foundation
development
utilization
functional
foods
healthy
food
products.
Microbiology Spectrum,
Journal Year:
2024,
Volume and Issue:
12(4)
Published: March 7, 2024
Enterotoxigenic
Escherichia
coli
(ETEC)
is
one
of
the
major
pathogens
contributing
to
piglet
diarrhea,
with
significant
implications
for
both
health
and
economic
aspects
livestock
industry.
SW207
an
isolate
Bacillus
halotolerans
isolated
from
cold-
disease-resistant
Leixiang
pigs
in
Northeastern
China.
We
have
discovered
that
can
survive
pig's
gastrointestinal
fluid
under
conditions
high
bile
salt
concentration,
displaying
potent
antagonistic
activity
against
ETEC.
In
this
study,
we
established
a
weaned
diarrhea
model
infected
ETEC
investigate
role
preventing
improving
intestinal
health.
Results
indicate
upregulates
expression
tight
junction
proteins,
including
claudin-1,
occludin,
zonula
occludens-1,
at
transcriptional
translational
levels.
Furthermore,
reduces
serum
endotoxin,
D-lactic
acid,
various
oxidative
stress
markers
while
enhancing
mechanical
barrier
function.
terms
immune
barrier,
suppressed
activation
TLR4/MyD88/NF-κB
pathway,
reducing
inflammatory
factors
upregulating
small
intestine
mucosal
sIgA.
Concerning
biological
significantly
content
E.
intestines
promotes
abundance
beneficial
bacteria,
thereby
mitigating
microbiota
imbalance
caused
by
summary,
has
potential
prevent
ETEC,
alleviate
inflammation
epithelial
damage,
facilitate
changes
microbiota.
This
contributes
elucidating
mechanisms
host-microbe
interactions
pathogen
infections.IMPORTANCEEnterotoxigenic
consistently
been
causing
mortality
piglets
pig
farming.
The
industry
traditionally
relied
on
antibiotic
administration
control
ETEC-induced
diarrhea.
However,
overuse
antibiotics
led
emergence
drug-resistant
zoonotic
bacterial
pathogens,
posing
threat
public
Therefore,
there
urgent
need
identify
alternatives
reduce
usage.
assessed
protective
effect
novel
probiotic
analyzed
its
vivo
vitro.
study
results
provide
theoretical
support
reference
implementing
interventions
gut
early
improve
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(9), P. 4695 - 4715
Published: Aug. 9, 2024
Polysaccharides
are
one
of
the
most
important
components
traditional
Chinese
medicine
(TCM)
and
have
been
extensively
studied
for
their
immunomodulatory
properties.
The
functions
effects
TCM
polysaccharides
closely
related
to
gut
microbiota,
making
study
interaction
a
hot
topic
in
field
metabolism.
This
review
follows
two
main
inquiries:
first,
how
microbiota
breaks
down
produce
bioactive
metabolites;
second,
reshape
as
carbon
source.
Understanding
mechanism
involves
challenging
equation
structural
association
with
metabolic
activities
microbiota.
has
meticulously
searched,
partially
organized
literature
spanning
past
decade,
that
delves
into
between
It
also
gives
an
overview
complex
factors
elusive
"polysaccharides-bond-bacteria-enzyme"
equation:
complexity
polysaccharide
structures,
diversity
glycosidic
bond
types,
communal
nature
metabolizing
enzymes
involved
functional
degradation
by
hierarchical
roles
utilization
locus
gram-positive
PULs.
Finally,
this
aims
facilitate
discussion
among
peers
offers
prospects
research
fields,
paving
way
pharmacological
studies
on
therapeutics,
providing
reference
point
further
clinical
research.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 12, 2025
Background
Bojanggunbi-tang
(BGT),
a
herbal
prescription
used
in
traditional
Korean
medicine,
has
been
to
treat
various
gastrointestinal
(GI)
diseases.
Methods
Studies
on
BGT
published
until
May
2024
were
retrieved
from
the
electronic
databases
of
Medline,
CENTRAL,
Embase,
AMED,
CNKI,
CiNii,
Kmbase,
KISS,
NDSL,
and
OASIS
using
GI-related
terms.
All
study
types,
regardless
research
method
or
language,
eligible
for
inclusion.
Additional
articles
Lonicera
japonica
,
Atractylodes
macrocephala
Alisma
canaliculatum
which
are
key
components
BGT,
Web
Science
GI-specific
The
basic
information,
models,
administration
methods,
evaluation
treatment
outcomes
selected
studies
examined
subsequently.
Results
Fourteen
studies,
comprising
nine
animal
one
cell-based
study,
four
human
included
final
analysis.
was
found
exhibit
anti-inflammatory
effects,
promote
restoration
mucosa,
regulate
GI
motility.
Analysis
L.
A.
revealed
that
they
inhibit
inflammatory
cytokines
oxidative
substances,
serotonin
cholinergic
pathways,
modulate
intestinal
microbiota.
Conclusion
This
scoping
review
confirmed
therapeutic
potential
mechanisms
action
its
main
components,
canaliculatum,
thereby
indicating
ability
enhance
health.
Further
including
randomized
clinical
trials,
must
be
conducted
future
confirm
these
findings.
Scoping
registration
registered
OSF,
an
international
database:
https://doi.org/10.17605/OSF.IO/ATU4S
.
Drug Design Development and Therapy,
Journal Year:
2025,
Volume and Issue:
Volume 19, P. 1869 - 1894
Published: March 1, 2025
Polygala
tenuifolia
Willd.
(PT)
is
commonly
used
to
address
cognitive
impairment
(CI),
while
Magnolia
officinalis
Rehd.
et
Wils
(MO)
often
prescribed
for
gastrointestinal
issues
as
well
CI.
This
study
seeks
explore
the
impacts
and
mechanisms
behind
combined
therapy
of
PT
MO
(PM)
in
treating
CI,
based
on
concept
gut-brain
axis.
The
characteristic
components
PT,
MO,
PM
were
identified
using
ultra-high
performance
liquid
chromatography-tandem
triple
quadrupole
mass
Spectrometry
(UPLC-MS/MS).
A
mouse
model
was
established
by
D-gal
induction,
effects
CI
evaluated
through
behavioral
tests,
pathological
staining,
Enzyme-Linked
Immunosorbent
Assay
(ELISA).
Subsequently,
network
pharmacology
analyze
potential
which
improves
followed
validation
Western
blotting
(WB),
traditional
Chinese
medicine
(TEM),
Immunofluorescence
(IF),
16S
rRNA.
can
each
alleviate
decline
neuropathological
damage
mice
varying
degrees,
reduce
expression
pro-inflammatory
factors
(TNF-α,
IL-1β,
IL-6,
IFN-γ,
LPS)
serum
or
hippocampal
tissue,
increase
SOD
GSH
levels.
Network
analysis
molecular
experiments
confirmed
that
upregulates
tight
junction
s
(TJs),
enhances
proteins
cAMP
pathway,
inhibits
p-NF-κB-p65
expression.
reverses
D-gal-induced
gut
microbiota
dysbiosis,
increases
abundance
SCFA-producing
bacteria,
decreases
LPS-producing
bacteria.
alleviates
reducing
inflammation
oxidative
stress,
protecting
blood-brain
barrier
(BBB)
intestinal
barrier,
inhibiting
NF-κB
activating
regulating
microbiota.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: March 28, 2025
Crohn's
disease
(CD)
and
ulcerative
colitis
(UC),
referred
to
as
inflammatory
bowel
(IBD),
pose
considerable
challenges
in
treatment
because
they
are
chronic
conditions
that
easily
relapse.
The
occurrence
of
IBD
continues
rise
developing
countries.
Nonetheless,
the
existing
therapies
for
have
limitations
fail
address
needs
patients
thoroughly.
There
is
an
increasing
need
new,
safe,
highly
effective
alternative
medications
patients.
Traditional
Chinese
Medicine
(TCM)
employed
drug
development
management
due
its
wide-range
biological
activities,
minimal
toxicity,
limited
side
effects.
Extensive
research
has
shown
certain
TCM
exhibits
significant
therapeutic
benefits
treatments.
Honeysuckle
(Lonicera
japonica)
was
used
clinical
settings
IBD.
Bioactive
metabolites
L.
japonica,
such
luteolin,
quercetin,
cyanidin,
chlorogenic
acid
(CGA),
caffeic
(CA),
saponin,
exhibit
managing
honeysuckle
flower
a
potential
candidate
anti-inflammatory,
immune
system-regulating,
antioxidant
qualities.
This
paper
reviews
It
discusses
fundamental
mechanism
japonica
bioactive
prevention
