The effect of specific immunoglobulins on sow milk parameters and piglet productivity DOI Creative Commons
Т. Ya. Prudyus

Ukrainian Journal of Veterinary and Agricultural Sciences, Journal Year: 2024, Volume and Issue: 7(3), P. 21 - 26

Published: Dec. 31, 2024

The study aimed to assess the effect of feed additive “Globigen Jump Start” on performance lactating sows and piglets at an early age. was conducted a pig farm, where 16 Velyka Bila breed were selected divided into control experimental groups. group added in 1 kg/t feed. addition contributed improvement quality sows' milk, particular increase content protein by 3.21 %, amino acids such as lysine (+8.05 %), macro- microelements, including calcium (+1.9 phosphorus (+6.9 %). This led live weight 12.38 % fifth day 10.56 28th. A decrease consumption observed 2.73 compared group, their loss during lactation decreased 5 %. In there average daily gain 18.52 observed. Thus, using rational allowed them improve productivity, ensure better growth development piglets, economic efficiency over years.

Language: Английский

Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome DOI Creative Commons

Min Du,

Xinran Liu, Xu Ji

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 14, 2025

Introduction Enterotoxic Escherichia coli (ETEC) is the main pathogen that causes diarrhea, especially in young children. This disease can lead to substantial morbidity and mortality a major global health concern. Managing ETEC infections challenging owing increasing prevalence of antibiotic resistance. Berberine, categorized as substance with similarities “medicine food,” has been used China for hundreds years treat gastrointestinal disorders bacteria-induced diarrhea. study investigated preventive effect dietary berberine on intestinal mucosal barrier induced by microbial community within intestines weaned piglets. Methods Twenty-four piglets were randomly divided into four groups. Piglets administered either standard diet or supplemented at concentrations 0.05 0.1%. orally saline. Results Dietary supplementation reduced diamine oxidase, d-lactate, endotoxin levels infected ( P < 0.05). Berberine increased jejunal villus height, villus/crypt ratio, thickness 0.05), goblet cell numbers villi crypts Furthermore, optical density mucin 2 2, P-glycoprotein, CYP3A4 mRNA expression expressions zonula occludins-1 (ZO-1), occludins-2 (ZO-2), Claudin-1, Occludin, E-cadherin ileum Moreover, BCL2, epithelial apoptosis 0.05) decreased BAX BAK duodenum jejunum, well CASP3 CASP9 IL-1β, IL-6, IL-8, TNF-α, IFN-γ elevated total volatile fatty acids, acetic acid, propionic valeric isovaleric acid Notably, enhanced abundance beneficial bacteria including Enterococcus, Holdemanella, Weissella, Pediococcus, Muribaculum, Colidextribacter, Agathobacter, Roseburia, Clostridium, Fusicatenibacter , Bifidobacterium . Simultaneously, relative harmful pathogenic bacteria, such Prevotella, Paraprevotella, Corynebacterium, Catenisphaera, Streptococcus, Enterobacter Collinsella Discussion alleviated ETEC-induced damage models. associated enhancement physical, chemical, immune functions enhancing microbiota homeostasis.

Language: Английский

Citations

1
Berberine alleviates ETEC-induced intestinal inflammation and oxidative stress damage by optimizing intestinal microbial composition in a weaned piglet model DOI Creative Commons
Yue Wang,

Z. Zhang,

Min Du

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 16, 2024

Introduction Enterotoxigenic Escherichia coli (ETEC) is the main diarrhea-causing pathogen in children and young animals has become a global health concern. Berberine type of “medicine food homology” long history use China, particularly treating gastrointestinal disorders bacterial diarrhea. Methods In this study, we explored effects berberine on growth performance, intestinal inflammation, oxidative damage, microbiota weaned piglet model ETEC infection. Twenty-four piglets were randomly divided into four groups—a control group (fed basal diet [BD] infused with saline), BD+ETEC ETEC), LB+ETEC 0.05% infection), HB+ETEC 0.1% ETEC). Results significantly improved final body weight (BW), average daily gain (ADG), feed intake (ADFI) ( P <0.05) piglets, effectively decreased incidence diarrhea among <0.05). Additionally, downregulated expression levels genes encoding TNF-α, IL-1β, IL-6, IL-8, TLR4, MyD88, NF-κB, IKKα, IKKβ small intestine infection upregulated coding for Nrf2, CAT, SOD1, GPX1, GST, NQO1, HO-1, GCLC, GCLM 12 functional COG categories 7 KEGG signaling pathways. A correlation analysis showed that increased relative abundance beneficial bacteria (Gemmiger, Pediococcus, Levilactobacillus, Clostridium, Lactiplantibacillus, Weissella, Enterococcus, Blautia, Butyricicoccus) pathogenic (Prevotella, Streptococcus, Parabacteroides, Flavonifractor, Alloprevotella) known to be closely related inflammation stress piglets. conclusion, disrupted upregulating TLR4/MyD88/NF-κB Nrf2 pathways, consequently leading stress-induced damage. Discussion Our data indicated can optimize balance modulate thus helping alleviate damage caused by

Language: Английский

Citations

5
Oxyberberine alleviates lipopolysaccharide-induced intestinal barrier disruption and inflammation in human colonic Caco-2 cells in vitro DOI Creative Commons
Cailan Li, Jiahao Wang, Hongmei Yang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Oxyberberine (OBB) is a naturally occurring isoquinoline alkaloid that believed to possess various health-promoting properties, including anti-fungus, hepatoprotection, anti-inflammation, and anti-intestinal mucositis effects. Despite several studies reporting the health benefits of OBB in treating ulcerative colitis (UC), its specific mechanism action has yet be fully elucidated. This investigation designed explore potential protective efficacy latent using an vitro model UC-like inflammatory intestinal cells. Caco-2 cells were pretreated with subsequently exposed lipopolysaccharide (LPS). The transepithelial electrical resistance (TEER), paracellular permeability, distribution expression tight- adherent junction proteins determined assess barrier integrity. levels proinflammatory cytokines, reactive oxygen species (ROS), Nrf2, NF-κB signaling cascade analyzed via ELISA, qRT-PCR, immunofluorescence, or Western blotting. was found mitigate effects LPS on cell monolayers, as evidenced by improvement TEER decrease FITC-dextran flux. Moreover, ameliorated LPS-induced tight markers, ZO-1, occludin, E-cadherin. In addition, treatment effectively inhibited increases ROS, apoptosis, Keap1 decreases Nrf2 HO-1. elevations nuclear p65 p-IκBα suppressed OBB. ML385, antagonist abolished role pronounced beneficial effect damage enteral function, regulation Nrf2/NF-κB pathway important responsible for protection afforded

Language: Английский

Citations

0
Bacillus safensis M01 reversed the inflammatory injury of mice jejunum caused by enterotoxigenic Escherichia coli K88 DOI

Xin-Wen Hou,

Jinxin Meng,

Xiaotong Chen

et al.

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(4)

Published: March 14, 2025

Language: Английский

Citations

0
Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota DOI Creative Commons
Jian Wu, Jing Zhang, Gang Huang

et al.

Renal Failure, Journal Year: 2024, Volume and Issue: 46(1)

Published: May 21, 2024

Research has showcased a correlation between disruptions in gut microbiota and primary membranous nephropathy (pMN), giving rise to the concept of 'gut-kidney axis'. However, precise relationship pMN remains elusive. Hence, this study endeavors investigate whether causal exists utilizing Mendelian randomization (MR) analysis.

Language: Английский

Citations

3
Bacillus spp. as potential probiotics: promoting piglet growth by improving intestinal health DOI Creative Commons
Xiaopeng Tang, Yan Zeng, Kangning Xiong

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: July 26, 2024

The application of

Language: Английский

Citations

2
Plant-Derived Polysaccharides Benefit Weaned Piglets by Regulating Intestinal Microbiota: A Review DOI
Huang Xiao-yan, Faming Jiang,

X Chen

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

The intestine harbors a community of bacteria that is intestinal microbiota, which complex and highly diverse community. This review discusses the gut microbiota in piglets, including role homeostasis maintaining piglet health various factors influence microbiota. Nutritional interventions, particularly supplementation plant-derived polysaccharides, dietary fiber, for weaned piglets have been shown to enhance abundance colonization beneficial microbes, reduce incidence gastrointestinal infections, decrease frequency diarrhea, thereby improving growth performance. In this context, such as those derived from

Language: Английский

Citations

1
The effect of specific immunoglobulins on sow milk parameters and piglet productivity DOI Creative Commons
Т. Ya. Prudyus

Ukrainian Journal of Veterinary and Agricultural Sciences, Journal Year: 2024, Volume and Issue: 7(3), P. 21 - 26

Published: Dec. 31, 2024

The study aimed to assess the effect of feed additive “Globigen Jump Start” on performance lactating sows and piglets at an early age. was conducted a pig farm, where 16 Velyka Bila breed were selected divided into control experimental groups. group added in 1 kg/t feed. addition contributed improvement quality sows' milk, particular increase content protein by 3.21 %, amino acids such as lysine (+8.05 %), macro- microelements, including calcium (+1.9 phosphorus (+6.9 %). This led live weight 12.38 % fifth day 10.56 28th. A decrease consumption observed 2.73 compared group, their loss during lactation decreased 5 %. In there average daily gain 18.52 observed. Thus, using rational allowed them improve productivity, ensure better growth development piglets, economic efficiency over years.

Language: Английский

Citations

0