An Overview on the Big Players in Bone Tissue Engineering: Biomaterials, Scaffolds and Cells

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3836 - 3836

Published: March 29, 2024

Presently, millions worldwide suffer from degenerative and inflammatory bone joint issues, comprising roughly half of chronic ailments in those over 50, leading to prolonged discomfort physical limitations. These conditions become more prevalent with age lifestyle factors, escalating due the growing elderly populace. Addressing these challenges often entails surgical interventions utilizing implants or grafts, though treatments may entail complications such as pain tissue death at donor sites for along immune rejection. To surmount challenges, engineering has emerged a promising avenue injury repair reconstruction. It involves use different biomaterials development three-dimensional porous matrices scaffolds, alongside osteoprogenitor cells growth factors stimulate natural regeneration. This review compiles methodologies that can be used develop are important replacement Biomaterials orthopedic implants, several scaffold types production methods, well techniques assess biomaterials’ suitability human use—both laboratory settings within living organisms—are discussed. Even researchers have had some success, there is still room improvements their processing techniques, especially ones make scaffolds mechanically stronger without weakening biological characteristics. Bone therefore area rise bone-related injuries.

Language: Английский

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Chitosan-based dental barrier membrane for periodontal guided tissue regeneration and guided bone regeneration: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139504 - 139504

Published: Jan. 5, 2025

Language: Английский

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Tunable mechanical properties of chitosan-based biocomposite scaffolds for bone tissue engineering applications: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 272, P. 132820 - 132820

Published: May 31, 2024

Language: Английский

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Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head

Journal of Tissue Engineering, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 1, 2025

Osteonecrosis of the femoral head (ONFH) is a prevalent orthopedic disorder characterized primarily by compromised blood supply. This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse at late stage, significantly impairing joint function. While MRI highly effective tool for diagnosing ONFH its early stages, challenges remain due to limited availability high cost MRI, as well absence routine screening asymptomatic patients. . In addition, current therapeutic strategies predominantly only relieve symptoms while disease-modifying drugs are still under investigation/development. Considering that supply plays key role pathology ONFH, angiogenic therapies have been put forward promising treatment options. Emerging bioengineering interventions targeting angiogenesis hold potential treatment. this review, we introduce advances research into summarize novel angiogenesis. review sheds light upon new directions future ONFH.

Language: Английский

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Chitosan-based biomaterials for bone tissue engineering

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140923 - 140923

Published: Feb. 1, 2025

Language: Английский

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Enhancing optical, structural, thermal, electrical properties, and antibacterial activity in chitosan/polyvinyl alcohol blend with ZnO nanorods: polymer nanocomposites for optoelectronics and food/medical packaging applications

Polymer Bulletin, Journal Year: 2024, Volume and Issue: 81(13), P. 11645 - 11670

Published: April 21, 2024

Language: Английский

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Research progress of injectable hydrogels in the treatment of bone tissue diseases

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155139 - 155139

Published: Aug. 24, 2024

Language: Английский

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Enhancing 3D Scaffold Performance for Bone Tissue Engineering: A Comprehensive Review of Modification and Functionalization Strategies

Journal of Science Advanced Materials and Devices, Journal Year: 2024, Volume and Issue: 9(4), P. 100806 - 100806

Published: Nov. 16, 2024

Language: Английский

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Microporous polylactic acid/chitin nanocrystals composite scaffolds using in-situ foaming 3D printing for bone tissue engineering

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135055 - 135055

Published: Aug. 30, 2024

Language: Английский

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In Vivo Anti-Inflammatory and Wound Healing Activity of Extracts and Micro-Aerogels of Bursera microphylla A. Gray

Stresses, Journal Year: 2025, Volume and Issue: 5(1), P. 10 - 10

Published: Jan. 27, 2025

Chitosan micro-aerogels (CsM) are an innovative strategy for the controlled release of healing and anti-inflammatory ingredients. Although Bursera microphylla has activity in vitro, its vivo effect is unknown. This study evaluated wound-healing effects extracts B. microphylla. loaded with 0.5% (CsMBT-0.5) 1% (CsMBT-1) ethanol extract were characterized by SEM, FTIR, TGA, moisture absorption. Cytotoxicity was assessed MTT assay, vitro NO quantification. Anti-inflammatory tested CD1 mice. The microparticles measured 135–180 μm. FTIR showed that extract’s compounds remained unchanged during synthesis. TGA indicated degradation between 250–350 °C reduced absorption when extract. inhibited 36% at 6.25 μg/mL CsMBT-1 46% 100 (p < 0.05). CsMBT-0.5 mice ear swelling 70% 30 mg/mL 0.0001). wound size day 9, while accelerated closure from 1 0.05), indicating chitosan a promising treatment option.

Language: Английский

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