Revista Eletrônica Acervo Saúde,
Journal Year:
2024,
Volume and Issue:
24(5), P. e15237 - e15237
Published: May 28, 2024
Objetivo:
Abordar
o
desafio
global
em
saúde
pública
e
as
alternativas
que
estão
sendo
desenvolvidas
no
combate
a
resistência
antimicrobiana.
Revisão
bibliográfica:
A
crescente
antimicrobiana
é
um
está
associada
alto
número
de
mortes
anuais
ameaça
superar
câncer
como
principal
causa
mortalidade
até
2050.
Ainda,
desenvolvimento
novos
antimicrobianos
enfrenta
obstáculos
significativos
incluindo
custo,
incerteza
mercado
falta
interesse
da
indústria
farmacêutica.
Buscando
atenuar
esse
cenário,
novas
antimicrobianas
demonstram
resultados
promissores.
terapia
fágica
utiliza
bacteriófagos
para
infectar
bactérias,
os
peptídeos
são
moléculas
aminoácidos
com
ação
direta
ou
imunomoduladora,
compostos
organometâlicos
redes
coordenação
metais
ligantes
orgânicos
propriedades
antimicrobianas.
Considerações
finais:
Cada
uma
das
descritas
apresenta
vantagens
desafios,
mas
todas
oferecem
esperança
eficazes.
representa
à
exige
busca
por
soluções
inovadoras
garantir
sucesso
contínuo
medicina
moderna.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
16(3)
Published: May 1, 2024
Abstract
The
misuse
of
antibiotics
has
led
to
increased
bacterial
resistance,
posing
a
global
public
health
crisis
and
seriously
endangering
lives.
Currently,
antibiotic
therapy
remains
the
most
common
approach
for
treating
infections,
but
its
effectiveness
against
multidrug‐resistant
bacteria
is
diminishing
due
slow
development
new
increase
drug
resistance.
Consequently,
developing
a\ntimicrobial
strategies
improving
efficacy
combat
infection
become
an
urgent
priority.
emergence
nanotechnology
revolutionized
traditional
treatment,
presenting
opportunities
refractory
infection.
Here
we
comprehensively
review
research
progress
in
nanotechnology‐based
antimicrobial
delivery
highlight
diverse
platforms
designed
target
different
resistance
mechanisms.
We
also
outline
use
combining
with
other
therapeutic
modalities
enhance
drug‐resistant
infections.
These
innovative
have
potential
susceptibility
overcome
Finally,
challenges
prospects
application
nanomaterial‐based
combating
are
discussed.
This
article
categorized
under:
Biology‐Inspired
Nanomaterials
>
Nucleic
Acid‐Based
Structures
Therapeutic
Approaches
Drug
Discovery
Nanomedicine
Infectious
Disease
Bioconjugate Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Bacterial
keratitis
is
a
prevalent,
and
severe
corneal
illness
resulting
from
bacterial
pathogens.
Failure
to
administer
timely
suitable
therapy
may
lead
opacity,
ulceration,
significant
vision
impairment,
or
potential
blindness.
Current
clinical
interventions
for
involve
the
administration
of
topical
antimicrobial
agents
systemic
antibiotics.
However,
misuse
overuse
antibiotics
have
led
rapid
emergence
antibiotic-resistant
bacteria.
Additionally,
restricted
antibacterial
spectrum
possible
adverse
effects
provided
considerable
obstacles
traditional
therapies.
This
highlights
urgent
need
novel
highly
effective
agents.
Antimicrobial
peptides
(AMPs)
are
class
naturally
occurring
synthetically
designed
small
molecules
that
gained
attention
due
their
unique
mechanisms
low
risk
resistance
development.
AMPs
exhibit
promising
in
treating
through
direct
mechanisms,
such
as
inhibiting
cell
wall
synthesis,
disrupting
membranes,
interfering
with
nucleic
acid
metabolism,
well
indirect
including
modulation
host
immune
response.
review
provides
comprehensive
overview
advancements
treatment
keratitis.
It
emphasizes
role
various
modification
strategies
artificial-intelligence-assisted
design
enhancing
efficacy,
stability,
biocompatibility
AMPs.
Furthermore,
this
discusses
latest
progress
combining
delivery
systems
improved
therapeutic
outcomes.
Finally,
current
challenges
future
perspectives
treatment,
providing
valuable
insights
developing
high
safety
mSystems,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
ABSTRACT
The
global
crisis
of
antimicrobial
resistance
poses
a
major
threat
to
human
health,
underscoring
the
urgency
developing
new
antibacterial
strategies.
Antimicrobial
peptides
(AMPs)
are
promising
alternatives
antibiotic
therapy,
yet
potential
microbial
is
great
concern.
Resistance
often
accompanied
by
fitness
costs,
which
may
in
turn
influence
spread
drug-resistant
bacteria
and
their
susceptibility
other
agents.
Herein,
we
investigate
evolutionary
trajectory
bacterial
antibiotics
AMPs
Escherichia
coli
,
evaluate
costs
collateral
sensitivity
strains.
We
reveal
that
E.
develops
antibiotics,
particularly
ciprofloxacin
kanamycin,
at
notably
faster
rate
than
AMPs.
Moreover,
antibiotic-evolved
strains
exhibit
slightly
higher
AMP-evolved
bacteria,
primarily
manifested
reduced
growth
swimming
motility.
Notably,
demonstrate
trimethoprim-resistant
coli,
with
mutations
thyA
gene,
displays
enhanced
pexiganan,
as
evidenced
both
vitro
vivo
studies.
Overall,
our
findings
shed
insights
for
clinical
deployment
propose
innovative
therapeutic
strategies
combating
antibiotic-resistant
infections.
IMPORTANCE
necessitates
development
anti-infective
represent
post-antibiotic
era.
By
monitoring
eight
ten
exhibits
slower
emergence
against
compared
antibiotics.
Additionally,
these
incur
significant
Most
importantly,
find
some
show
specific
animal
infection
models,
conducive
accelerating
AMP-based
treatment.
Macromolecular Rapid Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 29, 2025
As
the
clinical
prevalence
of
antibiotic-resistant
bacteria
rises,
effectiveness
antibacterial
drugs
has
been
greatly
reduced,
hence,
it
is
essential
to
create
novel
materials
for
combating
bacterial
infections.
In
recent
years,
antimicrobial
peptides
(AMPs)
have
demonstrated
significant
promise
in
addressing
infections
caused
by
bacteria,
but
as
a
natural
product,
they
are
limited
terms
activity
and
stability,
cannot
exert
their
full
effect.
The
conjugation
peptide-based
biomaterials
makes
up
this
shortcoming,
also
improved,
which
lays
foundation
its
application.
This
review
aims
introduce
current
progress
AMPs-based
treatment
multidrug-resistant
infections,
covering
topics
from
sources
delivery
combining
biomaterial
AMPs.
addition,
therapeutic
advantages,
including
synergistic
treatment,
improved
stability
effectiveness,
high
biocompatibility,
discussed.
Finally,
situation
prospects
AMP-based
summarized.
Academia molecular biology and genomics.,
Journal Year:
2025,
Volume and Issue:
2(1)
Published: March 31, 2025
The
biggest
threat
to
global
health,
which
claims
700,000
lives
annually,
is
the
appearance
and
quick
spread
of
multidrug
resistant
diseases.
mortality
rate
anticipated
rise
in
following
decade
owing
escalating
issue
antibiotic
resistance.
This
resistance
due
misuse
overuse
antibiotics,
allowing
infectious
bacteria
evolve
that
makes
treatments
ineffective.
Phage
therapy,
long
buried
by
an
era,
enjoying
a
well-deserved
renaissance
as
consequence
increase
leading
variety
illnesses
are
remediless.
rising
concern
has
made
scientific
body
more
cautious
about
developing
approach
without
considering
its
implications.
While
establishing
alternative
numerous
factors
must
be
taken
into
account,
including
relative
benefits
drawbacks.
Bacteriophages
provide
unique
insight
generation
innovative
medicines
will
lower
frequency
bacterial
since
they
host-specific.
As
globe
transitions
away
from
widespread
use
this
review
describes
prospective
utility,
strategies,
recent
developments,
clinical
studies
phage
therapy
while
also
highlighting
contemporary
for
MDR
bacteria.
