Transcriptomics Revealed Differentially Expressed Transcription Factors and MicroRNAs in Human Diabetic Foot Ulcers DOI Creative Commons
Vikrant Rai

Proteomes, Journal Year: 2024, Volume and Issue: 12(4), P. 32 - 32

Published: Nov. 5, 2024

Non-healing diabetic foot ulcers (DFUs) not only significantly increase morbidity and mortality but also cost a lot drain healthcare resources. Persistent inflammation, decreased angiogenesis, altered extracellular matrix remodeling contribute to delayed healing or non-healing. Recent studies suggest an increasing trend of DFUs in diabetes patients, non-healing DFYs the incidence amputation. Despite current treatment with offloading, dressing, antibiotics use, oxygen therapy, risk amputation persists. Thus, there is need understand molecular cellular factors regulating DFUs. The ongoing research based on proteomics transcriptomics has predicted multiple potential targets, no definitive therapy enhance chronic Increased expression various proteins encoded by genes, whose transcriptionally post-transcriptionally regulated transcription (TFs) microRNAs (miRs), regulates DFU healing. For this study, RNA sequencing was conducted 20 samples ulcer tissue non-ulcerated nearby healthy tissues. IPA analysis revealed activated inhibited microRNAs. Further network interactions between TFs miRs targets these miRs. 30 differentially expressed (21 9 inhibited), two translational regulators (RPSA EIF4G2), seven miRs, including mir-486, mir-324, mir-23, mir-186, mir-210, mir-199, mir-338 upstream (

Language: Английский

A cutting-edge investigation of the multifaceted role of SOX family genes in cancer pathogenesis through the modulation of various signaling pathways DOI
Saade Abdalkareem Jasim,

Shireen Hamid Farhan,

Irfan Ahmad

et al.

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 4, 2025

Language: Английский

Citations

1
Intervention of epithelial mesenchymal transition against colon cancer cell growth and metastasis based on SOX21/POU4F2/Hedgehog signaling axis DOI

Qiaochang Cao,

Yangyang Gao, Chenxi Zhou

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122905 - 122905

Published: July 9, 2024

Language: Английский

Citations

1
TCF4 promotes apoptosis and Wnt/β-catenin signaling pathway in acute kidney injury via transcriptional regulation of COX7A2L DOI Creative Commons

Minhui Xi,

Jingyuan Lu,

Hualin Qi

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(11), P. e0307667 - e0307667

Published: Nov. 5, 2024

Background Acute kidney injury (AKI) is still a serious illness with high morbidity and death rates, it’s crucial to comprehend the underlying molecular causes. Methods Bioinformatics analysis was performed on GSE139061 GSE30718 data sets, COX7A2L screened out. The role of in H/R-treated cells its transcriptional regulation TCF4 were assessed. In vitro experiments analyzed proliferation, apoptosis, Wnt/β-catenin signaling pathway cells. Results as hub gene downregulated AKI samples. cells, overexpression inhibited apoptosis promoted cell while knockdown proliferation. Notably, exhibited significant positive correlation COX7A2L. overexpression-induced lessened improved proliferation countered by knockdown, according rescue study findings. Besides, we discovered that increased expression proteins linked (c-myc, β-catenin, cyclin D1), underexpression counteracted this effect. Conclusion revealed pivotal AKI, which regulated modulates pathway, highlighting potential therapeutic target.

Language: Английский

Citations

1
Transcriptomics Revealed Differentially Expressed Transcription Factors and MicroRNAs in Human Diabetic Foot Ulcers DOI Creative Commons
Vikrant Rai

Proteomes, Journal Year: 2024, Volume and Issue: 12(4), P. 32 - 32

Published: Nov. 5, 2024

Non-healing diabetic foot ulcers (DFUs) not only significantly increase morbidity and mortality but also cost a lot drain healthcare resources. Persistent inflammation, decreased angiogenesis, altered extracellular matrix remodeling contribute to delayed healing or non-healing. Recent studies suggest an increasing trend of DFUs in diabetes patients, non-healing DFYs the incidence amputation. Despite current treatment with offloading, dressing, antibiotics use, oxygen therapy, risk amputation persists. Thus, there is need understand molecular cellular factors regulating DFUs. The ongoing research based on proteomics transcriptomics has predicted multiple potential targets, no definitive therapy enhance chronic Increased expression various proteins encoded by genes, whose transcriptionally post-transcriptionally regulated transcription (TFs) microRNAs (miRs), regulates DFU healing. For this study, RNA sequencing was conducted 20 samples ulcer tissue non-ulcerated nearby healthy tissues. IPA analysis revealed activated inhibited microRNAs. Further network interactions between TFs miRs targets these miRs. 30 differentially expressed (21 9 inhibited), two translational regulators (RPSA EIF4G2), seven miRs, including mir-486, mir-324, mir-23, mir-186, mir-210, mir-199, mir-338 upstream (

Language: Английский

Citations

0