Enhanced antibacterial activity of porous chitosan-based hydrogels crosslinked with gelatin and metal ions

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 29, 2024

Abstract Addressing the increasing drug resistance in pathogenic microbes, a significant threat to public health, calls for development of innovative antibacterial agents with versatile capabilities. To enhance antimicrobial activity non-toxic biomaterials this regard, study focuses on novel, cost-effective chitosan (CS)-based hydrogels, crosslinked using gelatin (GEL), formaldehyde, and metallic salts (Ag + , Cu 2+ Zn ). These hydrogels are formed by mixing CS GEL creating iminium ion crosslinks without hazardous crosslinkers. Characterization techniques like FTIR, XRD, FESEM, EDX, rheological tests were employed. FTIR analysis showed metal ions binding amino hydroxyl groups CS, enhancing hydrogelation. FESEM revealed that freeze-dried possess crosslinked, porous structure influenced various ions. Antibacterial testing against gram-negative gram-positive bacteria demonstrated bacterial growth inhibition. CS-based containing reduced MIC MBC values Staphylococcus aureus (0.5, 8, 16 µg/mL) Escherichia coli (1, 16, 8 CS-g-GEL-Ag CS-g-GEL-Cu CS-g-GEL-Zn . MTT assay results confirmed high biocompatibility (84.27%, 85.24%, 84.96% viability at 10 towards HFF-1 cells over 48 h. Therefore, due their nature, these promising applications.

Language: Английский

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Efficacy of melanin-loaded lipoic acid-modified chitosan hydrogel in diabetic wound healing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 340, P. 122215 - 122215

Published: May 3, 2024

Language: Английский

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Development of active hydrogel absorbent pads based on sodium alginate/potassium-doped carbon dots for chilled pork preservation

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 155, P. 110229 - 110229

Published: May 25, 2024

Language: Английский

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Enhanced methylene blue adsorption using single-walled carbon nanotubes/chitosan-graft-gelatin nanocomposite hydrogels

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 19, 2024

In the present study, single-walled carbon nanotubes (SWCNTs) incorporating chitosan-graft-gelatin (CS-g-GEL/SWCNTs) hydrogels were fabricated with multiple advantages, including cost-effectiveness, high efficiency, biodegradability, and ease of separation for methylene blue (MB) dye from aqueous solution. To verify successful formulation prepared hydrogels, various characterization methods such as NMR, FTIR, XRD, FE-SEM, TGA, BET, EDX employed. The removal efficiency CS-g-GEL/SWCNTs nanocomposite hydrogel increased significantly to 98.87% when SWCNTs percentage was 20%. highest adsorption observed pH = 9, an adsorbent dose 1.5 g L

Language: Английский

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Hierarchical Mineralized Collagen Coated Zn Membrane to Tailor Cell Microenvironment for Guided Bone Regeneration

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Maxillofacial bone defects caused by trauma, infections, tumors, and congenital disorders have become a significant global health concern. An ideal guided regeneration (GBR) membrane is expected to not only act as barrier but also promote osteoinduction osteogenesis. However, non‐resorbable membranes limited bioactivity require secondary surgeries, whereas resorbable often lack the required mechanical properties degrade too quickly. To address these challenges, bilayer self‐induced GBR constructed combining pure zinc (Zn) hierarchical mineralized collagen (HMC) via self‐assembly, termed ss‐HMC/Zn. The Zn layer acts an outer toward soft tissue that provides spatiotemporal support, HMC creates favorable internal osteogenic microenvironment. Moreover, bone‐like nanostructure of effectively controlled release ions. In vitro assays demonstrates adequate maintenance, excellent cytocompatibility, ability membrane. vivo results show superior osteoinductive capability without need for supplements. Furthermore, ss‐HMC/Zn exhibits immunomodulatory functions, promoting angiogenesis cell recruitment, thereby shedding light on underlying mechanisms. conclusion, well‐orchestrated provide new insights into maxillofacial defects.

Language: Английский

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Design and biofabrication of barnacle and spider silk protein decorated composite bacterial cellulose for diabetic wound healing

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 354, P. 123301 - 123301

Published: Jan. 20, 2025

Language: Английский

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Incorporating Insulin into Alginate-Chitosan 3D-Printed Scaffolds: A Comprehensive Study on Structure, Mechanics, and Biocompatibility for Cartilage Tissue Engineering

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100696 - 100696

Published: Feb. 1, 2025

Language: Английский

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A dynamically cross-linked catechol-grafted chitosan/gelatin hydrogel dressing synergised with photothermal therapy and baicalin reduces wound infection and accelerates wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132802 - 132802

Published: June 12, 2024

Language: Английский

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Nano hydrogel with bacterial nanocellulose and bitter almond oil nanoemulsions for enhanced wound healing: In-vivo and in-vitro characterization

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134134 - 134134

Published: July 23, 2024

Language: Английский

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Conjugated electrospinning toward a polycaprolactone scaffold simultaneously containing micro-/nano- fibers for potential biomedical application

Journal of Polymer Research, Journal Year: 2024, Volume and Issue: 31(10)

Published: Sept. 29, 2024

Language: Английский

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