Incorporation of essential oils in polymeric films for biomedical applications

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 132108 - 132108

Published: May 6, 2024

Language: Английский

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In situ sono-rheometric assessment of procaine-loaded calcium pectinate hydrogel for enhanced drug releasing under ultrasound stimulation

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 130164 - 130164

Published: Feb. 16, 2024

Language: Английский

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Photo-crosslinking modified gelatin-silk fibroin hydrogel for accelerating wound repair of open abdomen

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 154161 - 154161

Published: July 21, 2024

Language: Английский

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Chitosan‐Graft‐Gelatin Hydrogel Containing Bromothymol Blue as a Food Spoilage Indicator for Intelligent Food Packaging

Advanced Materials Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract A remarkable one‐third of global food production is wasted, resulting in significant economic damage and escalating insecurity. To address this sustainability challenge, freshness identification packaging using intelligent materials has gained traction. This work introduces a chitosan‐ graft ‐gelatin (CS‐g‐GEL) hydrogel, incorporating pH‐responsive dye, bromothymol blue (BTB), as colorimetric indicator to monitor the spoilage chicken breasts. The successful formulation hydrogels verified FTIR, AFM, SEM, TGA, 1 HNMR characterization techniques. At pH 5 7.4, swelling capacity hydrogel 790% 470%, respectively. rise colony‐forming units (CFU) from 5.5 on day 1–7.4 log CFU g −1 7 indicate microbial activity, carbon dioxide due deteriorating decreases package. Additionally, CO 2 concentrations 3.2 1–22.1 (% v/v) 7, while O levels 23.8 near 0.5 same period. developed demonstrated serve smart visual offers new dimension use toward challenge.

Language: Английский

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Bioplastics from Shellfish Waste: Tuning the Tensile and Solubility Properties of Chitosan Films

ACS Sustainable Resource Management, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Chitosans of varying molecular weights were solubilized with acids (lactic, acetic, and malic) formed into films glycerin added as a plasticizer, additional treatments applied to tune the solubility tensile properties films. Lactic acid chitosan made that had wider range when tuned by concentration. Neutralizing led strength increasing from 16.48 58.95 MPa, loss in strain at break percent decreasing 47.95% 28.19%. A plasticizer bath after neutralization glycerin-containing film leads an increase stress 17.97 26.44 MPa. The neutralized without show 54.94 42.42 MPa 98% humidity, while sample decreases 41.10 8.11 Having mechanisms for tunability increases applicability sustainably produced replacements petroleum-derived plastics single-use packaging, textiles, many other applications.

Language: Английский

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Dual-layer alginate hydrogel dressings with chitosan nanofibers for enhanced wound healing, infection prevention, and controlled drug release

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 307, P. 142033 - 142033

Published: March 14, 2025

Language: Английский

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Bioengineered tetra-PEG-COLIII-SCS hydrogel: A rapid wet-adhesive multifunctional platform for scarless repair of dynamic diabetic wound

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162931 - 162931

Published: April 1, 2025

Language: Английский

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Enhanced biological properties of polyvinyl alcohol-polycaprolactone/hyaluronic acid-coated electrospun scaffolds for articular cartilage regeneration

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 29

Published: April 23, 2025

This study provides a cohesive framework to putting forth PVA-PCL scaffolds coated with hyaluronic acid (HA) hydrogel mimic the characteristics of articular cartilage, as cost-effective tissue engineering alternative. PVA and PCL solutions were prepared electrospun under measured conditions, parameters adjusted fabricate aligned random fiber orientations. Afterward, scaffold was integrated optimal hydrogel, selected for its superior water absorption hydrophilicity. The thickness layer satisfied criteria supporting chondrocyte function, assesses effect on cell viability. Scaffolds characterized using field emission scanning electron microscopy (FE-SEM) morphology, energy-dispersive X-ray spectroscopy (EDX) elemental analysis, Fourier transform infrared (FTIR) chemical composition, tensile tests mechanical behavior. surface wettability determined by contact angle measurements. Biological properties assessed through cytotoxicity, protein assays adhesion visualization distribution DAPI staining, fluorescence microscopy, FE-SEM. Using hydrolytic mechanism, biodegradation pH variations weight loss Accordingly, randomly oriented hydrogel-coated yielded most favorable biological outcomes produce tissue-friendly, biologically robust graft that closely mimics natural cartilage extracellular matrix. pore size these more uniform than those structures. findings suggest possibilities customizing orientation, polymer blending, coating optimize response formation. Combining chondrocytes-seeded hydrogels offers way improve regeneration.

Language: Английский

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The combination of modified acupuncture needle and melittin hydrogel as a novel therapeutic approach for rheumatoid arthritis treatment

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 22, 2024

Abstract Rheumatoid arthritis (RA) involves chronic joint inflammation. Combining acupuncture and medication for RA treatment faces challenges like spatiotemporal variability, limited drug loading in needles, premature or untargeted release. Here, we designed a new type of tubular with an etched hollow honeycomb-like structure to enable the high therapeutics, integrating traditional repository into all-in-one therapeutic platform. In these proof-of-concept experiments, fabricated injectable honeycomb electroacupuncture needles (HC-EA) loaded melittin hydrogel (MLT-Gel), enabling combination stimulation therapy spatiotemporally synchronous manner. Since microenvironment is mildly acidic, acid-responsive chitosan (CS)/sodium beta-glycerophosphate (β-GP)/ hyaluronic acid (HA) composited (CS/GP/HA) was utilized perform achieve targeted release injected therapeutics specific lesion site. Testing our platform involved mouse model bioinformatics analysis. MLT-Gel@HC-EA restored Th17/Treg-mediated immunity balance, reduced inflammatory factor (TNF-α, IL-6, IL-1β), alleviated inflammation at This novel modified needle medication, specifically hydrogel, holds promise as strategy treatment. Graphical abstract

Language: Английский

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Chitosan-graft-Pomegranate Extract Hydrogel: A Dual-Functional Pad for Antibacterial and Antioxidant Enhancement for Shelf Life Extension in Food Packaging

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 6(16), P. 9545 - 9558

Published: Aug. 14, 2024

In the preservation of water-rich foods, especially meat, spoilage can occur due to bacterial contamination and oxidative degradation. This study aimed determine structural characteristics synthesis chitosan-graft-pomegranate extract (CS-g-POM) hydrogel using a cost-effective biobased method develop antibacterial antioxidant pads. Pomegranate is used fabricate covalently noncovalently interconnected chitosan networks. Several characterization methods, such as Fourier transform infrared spectroscopy, thermogravimetric analysis, field emission scanning electron microscopy, atomic force rheological confirmed successful design produced hydrogel. The freeze-dried CS-g-POM had swelling ratio 373%, 614%, 508.5% at pH 5, 7.4, 10, respectively. FE-SEM images showed porous hydrogel, which cross-linking process. addition pomegranate increased phenolic content, resulting in DPPH radical scavenging activity 50.20%. also good properties, with inhibition zones against Escherichia coli Staphylococcus aureus measuring 18 ± 1 mm 12 mm. plays crucial role moisture absorption foods meat its high degree could be an pad.

Language: Английский

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