The Complexity and Significance of Fibroblast Growth Factor (FGF) Signaling for FGF-Targeted Cancer Therapies DOI Open Access
A. Nguyen,

Caroline O. Facey,

Bruce M. Boman

et al.

Cancers, Journal Year: 2024, Volume and Issue: 17(1), P. 82 - 82

Published: Dec. 30, 2024

Fibroblast growth factors (FGFs) have diverse functions in the regulation of cell proliferation and differentiation development, tissue maintenance, wound repair, angiogenesis. The goal this review paper is to (i) deliberate on role FGFs FGF receptors (FGFRs) different cancers, (ii) present advances FGF-targeted cancer therapies, (iii) explore signaling mechanisms that explain how expression becomes dysregulated during development. often mutated overexpressed FGFR isoforms unique patterns distinct roles cancers. Among members, 15/19 subfamily particularly interesting because its protein structure endocrine function. abnormal types (breast, colorectal, hepatobiliary, bronchogenic, others) examined correlated with patient prognosis. classification ligands based their mode action, whether autocrine, paracrine, endocrine, or intracrine, illustrated, an analysis binding specificity FGFRs also provided. Moreover, latest therapeutic strategies involving small molecules, ligand traps, monoclonal antibody-based inhibitors are presented. Lastly, we discuss dysregulation affects

Language: Английский

HER2-targeted therapies beyond breast cancer — an update DOI
Jeesun Yoon, Do‐Youn Oh

Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(9), P. 675 - 700

Published: July 22, 2024

Language: Английский

Citations

20
Unlocking the power of imidazoquinolines: recent advances in anticancer and immunotherapeutic strategies DOI

Ranjini Jenifer R,

Badruzzaman Choudhury,

Mohammed Mujahid Alam

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: April 15, 2025

The challenges in drug discovery aiming to mitigate cancer progression are the thrust area of scientific research for several decades. Since advent heterocyclic chemistry, programs have made significant achievements that lead development numerous drugs with broad spectrum potencies, contributing both diagnostic and therapeutic advancements. Till date, efforts discover more potent efficient candidates underway minimize adverse side effects existing chemotherapeutics. In view above, small-molecule agonists can interact different immune modulators like toll receptor-7 (TLR-7) TLR-8 being investigated explored. These expected display profound effect on anti-tumoral activity by enhancing production proinflammatory cytokines. Recently, imidazoquinoline derivatives proven TLR agonist activities emerged as promising anticancer therapeutics. With advancements technology evolution new scopes discovery, strategies adopted, particularly help nanotechnology, immune-technology, combination etc., curb various types cancers. Herein, novel therapeutics imidazoquinolines reported last 5 years, their structure-activity relationship along important synthetic schemes agonists, discussed.

Language: Английский

Citations

0
Receptor tyrosine kinases in breast cancer treatment: unraveling the potential DOI
Qi Yu,

Shumin Deng,

Kuan-Song Wang

et al.

American Journal of Cancer Research, Journal Year: 2024, Volume and Issue: 14(9), P. 4172 - 4196

Published: Jan. 1, 2024

Breast cancer is a multifactorial disease driven by acquired genetic and epigenetic changes that lead to aberrant regulation of cellular signaling pathways. Receptor tyrosine kinases (RTKs), class critical receptors, are involved in the initiation progression breast cancer. RTKs cell surface receptors with unique structures biological characteristics, which respond environmental signals initiating cascades such as mitogen-activated protein kinase (MAPK) pathway, Janus (JAK)/signal transducer, activator transcription (STAT) phosphoinositide 3-kinase (PI3K)/AKT pathway. The role makes them suitable targets for treatment. Targeted therapies against have been developed recent years, evaluated clinical trials, approved several types, including However, displays molecular heterogeneity exhibits different therapeutic responses various drug leading limited effectiveness targeted therapy RTKs. In this review, we summarize structural functional characteristics selected discuss mechanisms current status involving progression.

Language: Английский

Citations

1
The Complexity and Significance of Fibroblast Growth Factor (FGF) Signaling for FGF-Targeted Cancer Therapies DOI Open Access
A. Nguyen,

Caroline O. Facey,

Bruce M. Boman

et al.

Cancers, Journal Year: 2024, Volume and Issue: 17(1), P. 82 - 82

Published: Dec. 30, 2024

Fibroblast growth factors (FGFs) have diverse functions in the regulation of cell proliferation and differentiation development, tissue maintenance, wound repair, angiogenesis. The goal this review paper is to (i) deliberate on role FGFs FGF receptors (FGFRs) different cancers, (ii) present advances FGF-targeted cancer therapies, (iii) explore signaling mechanisms that explain how expression becomes dysregulated during development. often mutated overexpressed FGFR isoforms unique patterns distinct roles cancers. Among members, 15/19 subfamily particularly interesting because its protein structure endocrine function. abnormal types (breast, colorectal, hepatobiliary, bronchogenic, others) examined correlated with patient prognosis. classification ligands based their mode action, whether autocrine, paracrine, endocrine, or intracrine, illustrated, an analysis binding specificity FGFRs also provided. Moreover, latest therapeutic strategies involving small molecules, ligand traps, monoclonal antibody-based inhibitors are presented. Lastly, we discuss dysregulation affects

Language: Английский

Citations

1