Journal of Biomedical Materials Research Part A,
Journal Year:
2024,
Volume and Issue:
112(12), P. 2257 - 2272
Published: July 15, 2024
Abstract
As
the
cornerstone
of
tissue
engineering
and
regeneration
medicine
research,
developing
a
cost‐effective
bionic
extracellular
matrix
(ECM)
that
can
precisely
modulate
cellular
behavior
form
functional
remains
challenging.
An
artificial
ECM
combining
polysaccharides
fibrillar
proteins
to
mimic
structure
composition
natural
provides
promising
solution
for
cardiac
regeneration.
In
this
study,
we
developed
hydrogel
scaffold
by
quaternized
β
‐chitin
derivative
(QC)
fibrin‐matrigel
(FM)
in
different
ratios
ECM.
We
evaluated
stiffness
those
composite
hydrogels
with
mixing
their
effects
on
growth
human
umbilical
vein
endothelial
cells
(HUVECs).
The
optimal
hydrogels,
QCFM1
were
further
applied
load
HUVECs
into
nude
mice
vivo
angiogenesis.
Besides,
encapsulated
pluripotent
stem
cell‐derived
cardiomyocytes
(hPSC‐CMs)
QCFM
employed
3D
bioprinting
achieve
batch
fabrication
human‐engineered
heart
(hEHT).
Finally,
myocardial
electrophysiological
function
hEHT
immunofluorescence
optical
mapping.
Designed
has
tunable
modulus
(220–1380
Pa),
which
determines
when
these.
(800
Pa)
porous
architecture
finally
identified,
could
adapt
vitro
cell
spreading
angiogenesis
HUVECs.
Moreover,
successfully
both
ring‐shaped
patch‐shaped
hEHT.
These
hydrogels‐based
hEHTs
possess
organized
sarcomeres
advanced
characteristics
comparable
reported
hEHTs.
chitin‐derived
are
first
used
functionalized
myocardium.
Specifically,
these
novel
provided
reliable
economical
choice
serving
as
ideal
application
medicine.
IGI Global eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 531 - 566
Published: April 25, 2025
The
application
of
biomaterials
in
the
biomedical
field
represents
a
major
advancement,
offering
effective
and
sustainable
alternative
solutions.
These
materials
stand
out
for
their
unique
properties,
particularly
biocompatibility
biodegradability.
However,
choice
between
animal
or
non-animal
sources
constitutes
primary
challenge,
directly
influencing
use
effectiveness
various
contexts.
This
chapter
offers
comparative
analysis
origin,
highlighting
distinct
properties
adaptability
to
applications,
while
mentioning
limitations
each
type
source.
multidimensional
thus
provides
critical
framework
guiding
based
on
specific
needs
applications
opens
up
perspectives
development
hybrid
capable
overcoming
these
limitations.
Current Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
28(15), P. 1190 - 1214
Published: May 15, 2024
Abstract:
The
usage
of
nanoparticles
in
tissue
engineering
applications
has
increased
significantly
the
last
several
years.
Functional
tissues
are
developed
by
regulating
cell
proliferation,
differentiation,
and
migration
on
nanostructured
scaffolds
containing
cells.
These
provide
an
environment
that
is
more
structurally
supportive
than
microarchitecture
natural
bone.
Given
its
exceptional
properties,
such
as
osteogenic
potential,
biocompatibility,
biodegradability,
chitosan
a
good
promising
biomaterial.
Unfortunately,
chitosan's
low
mechanical
strength
makes
it
unsuitable
for
load-bearing
applications.
By
mixing
with
other
biomaterials,
this
drawback
might
be
mitigated.
Bone
uses
both
bioresorbable
materials
like
tricalcium
phosphate
bioactive
hydroxyapatite
bioglass.
Alumina
titanium
examples
bioinert
part
these
bioceramics.
When
produced
at
nanoscale
scales,
have
larger
surface
area
better
adhesion.
This
review
paper
will
go
into
great
detail
bioinert,
bioresorbable,
nanoceramics-reinforced
bone
engineering.
Journal of Biomedical Materials Research Part A,
Journal Year:
2024,
Volume and Issue:
112(12), P. 2257 - 2272
Published: July 15, 2024
Abstract
As
the
cornerstone
of
tissue
engineering
and
regeneration
medicine
research,
developing
a
cost‐effective
bionic
extracellular
matrix
(ECM)
that
can
precisely
modulate
cellular
behavior
form
functional
remains
challenging.
An
artificial
ECM
combining
polysaccharides
fibrillar
proteins
to
mimic
structure
composition
natural
provides
promising
solution
for
cardiac
regeneration.
In
this
study,
we
developed
hydrogel
scaffold
by
quaternized
β
‐chitin
derivative
(QC)
fibrin‐matrigel
(FM)
in
different
ratios
ECM.
We
evaluated
stiffness
those
composite
hydrogels
with
mixing
their
effects
on
growth
human
umbilical
vein
endothelial
cells
(HUVECs).
The
optimal
hydrogels,
QCFM1
were
further
applied
load
HUVECs
into
nude
mice
vivo
angiogenesis.
Besides,
encapsulated
pluripotent
stem
cell‐derived
cardiomyocytes
(hPSC‐CMs)
QCFM
employed
3D
bioprinting
achieve
batch
fabrication
human‐engineered
heart
(hEHT).
Finally,
myocardial
electrophysiological
function
hEHT
immunofluorescence
optical
mapping.
Designed
has
tunable
modulus
(220–1380
Pa),
which
determines
when
these.
(800
Pa)
porous
architecture
finally
identified,
could
adapt
vitro
cell
spreading
angiogenesis
HUVECs.
Moreover,
successfully
both
ring‐shaped
patch‐shaped
hEHT.
These
hydrogels‐based
hEHTs
possess
organized
sarcomeres
advanced
characteristics
comparable
reported
hEHTs.
chitin‐derived
are
first
used
functionalized
myocardium.
Specifically,
these
novel
provided
reliable
economical
choice
serving
as
ideal
application
medicine.
