Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cell DOI Creative Commons
Feifan Zhang,

Yang Hao,

Ning Yang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 12, 2023

Abstract Background Osteosarcoma (OS) is one of the most common aggressive bone malignancy tumors in adolescents. With no significant advances treatment OS recent ten years, discovering new and effective anti-OS drugs became our top priority. Oridonin has been proved to mediate anti-tumor impact on cells, although it’s mechanism action not fully understood. Methods Here, we investigated inhibitory effect oridonin cells its underlying mechanisms. In 143B U2OS oridonin’s pro-apoptosis pro-ferroptosis effects cell death, proliferation, migration, iron accumulation, mitochondrial membrane potential lipid peroxidation production were observed. Western blot (WB) real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) used detect expression levels apoptosis ferroptosis-relative proteins genes. Iron assay Kit was evaluate relative Fe 2+ content. The detection kit ROS production. changes malignant phenotype examined after treating with ferroptosis inhibitor ferrostatin-1 (Fer-1). Results potently inhibited viability metastasis. Simultaneously, suppressed expressions BAX, cl-caspase3, SLC7A11, GPX4 FTH1 mRNA, while promoting Bcl-2 ACSL4 143 cells. Furthermore, found that also boosted accumulation reactive oxygen species (ROS), encouraged buildup , decreased but this can be reversed by Fer-1. Conclusion trigger collaboratively making it a promising agent for therapy.

Language: Английский

Prodrug-conjugated tumor-seeking commensals for targeted cancer therapy DOI Creative Commons
Haosheng Shen, Changyu Zhang, Shengjie Li

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 21, 2024

Abstract Prodrugs have been explored as an alternative to conventional chemotherapy; however, their target specificity remains limited. The tumor microenvironment harbors a range of microorganisms that potentially serve tumor-targeting vectors for delivering prodrugs. In this study, we harness bacteria-cancer interactions native the microbiome achieve high prodrug delivery. We identify oral commensal strain Lactobacillus plantarum with intrinsic cancer-binding mechanism and engineer enable surface loading anticancer prodrugs, nasopharyngeal carcinoma (NPC) model cancer. engineered commensals show specific binding NPC via OppA-mediated recognition heparan sulfate, loaded prodrugs are activated by tumor-associated biosignals release SN-38, chemotherapy compound, near NPC. vitro experiments demonstrate prodrug-loaded microbes significantly increase potency SN-38 against cell lines, up 10-fold. mouse xenograft model, intravenous injection L. leads bacterial colonization in tumors 67% inhibition growth, enhancing efficacy 54%.

Language: Английский

Citations

15
Cellular preconditioning and mesenchymal stem cell ferroptosis DOI
Doaa Hussein Zineldeen, Mazhar Mushtaq, Khawaja Husnain Haider

et al.

World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(2), P. 64 - 69

Published: Feb. 25, 2024

In this editorial, we comment on the article published in recent issue of

Language: Английский

Citations

5
Ferroptosis-Related Oxaliplatin Resistance in Multiple Cancers: Potential Roles and Therapeutic Implications DOI Creative Commons

Si-Jia Zhong,

Zihan Wang,

Jiaxi Yang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e37613 - e37613

Published: Sept. 1, 2024

Oxaliplatin (OXA)-based therapy is effective in the treatment of multiple cancers. However, primary or acquired OXA resistance remains an emerging challenge for its clinical application. Ferroptosis iron-dependent mode cell death that has been demonstrated to play essential role chemoresistance many drugs, including OXA. In particular, dysregulation SLC7A11-GPX4, one major antioxidant systems ferroptosis, was found colorectal cancer (CRC) and hepatocellular carcinoma (HCC). addition, Nrf2, upstream regulator GPX4 other factors, also involved CRC HCC. Inhibition SLC7A11-GPX4 Nrf2 by genetic deletion pharmaceutical inhibition could significantly reverse resistance. Long noncoding RNA (lncRNA) participates ferroptosis cells. Specifically, LINC01134 promotes recruitment promoter GPX4, thereby exerting transcriptional regulation which eventually increases sensitivity HCC through upregulation ferroptosis. On hand, a novel lncRNA DACT3-AS1 sensitizes gastric cells miR-181a-5p/sirtuin 1(SIRT1)-mediated Therapies based on combination enhancers provide new therapeutic insights overcome present review, we current understanding ferroptosis-related resistance, highlight pathogenesis chemoresistance, summarize available therapies target enhancing

Language: Английский

Citations

5
Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma DOI Creative Commons
Haihua Wang, Songqing Fan, Yuting Zhan

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 16, 2025

Approximately 80% of nasopharyngeal carcinoma (NPC) patients exhibit EGFR overexpression. The overexpression has been linked to its potential role in modulating major histocompatibility complex class I (MHC-I) molecules. We discovered that EGFR, operating a kinase-independent manner, played stabilizing the expression SLC7A11, which subsequently inhibited MHC-I antigen presentation. This mechanism, turn, provided protection NPC cells against T cell-mediated cytotoxicity. underlying molecular processes revealed high and stable SLC7A11 hindered nuclear entry GR, thereby suppressing TAP1 transcription presentation Additionally, elevated led an increase FAF2 triggered ERAD-dependent degradation MHC-I, resulting reduction molecules on cell membrane. exhibiting low expression, combined with scarcity CD8+ (EGFRhighMHC-IlowCD8few phenotype), experienced considerably shorter overall survival times compared other situations. What is more, our study demonstrated sorafenib had capability enhance process, facilitating killing via targeting SLC7A11. Consequently, emerges as promising therapeutic strategy for treatment NPC.

Language: Английский

Citations

0
Identification and molecular mechanism study of a novel small molecule inhibitor targeting solute carrier family 7 member 11 for the treatment of hepatocellular carcinoma DOI
Xiaomeng Wang, Yan Yang, Qiao Fu

et al.

New Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Ferroptosis plays an extremely significant role in the development of hepatocellular carcinoma (HCC), and targeting tumor cells to induce ferroptosis has emerged as a new approach for treatment cancer.

Language: Английский

Citations

0
JMJD6 K375 acetylation restrains lung cancer progression by enhancing METTL14/m6A/SLC3A2 axis mediated cell ferroptosis DOI Creative Commons

Huanxiang Chen,

Nan Xiao,

Chenxing Zhang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 26, 2025

Language: Английский

Citations

0
Ferroptosis and protein translation: emerging perspectives in the research of myocardial infraction DOI Creative Commons

Qi Lan,

Qiuyu Liu, Wenjuan Qiu

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 2, 2025

Myocardial infarction, as the principal type of ischemic heart disease, has currently become focus research on its prevention and treatment strategies. From perspective myocardial infarction pathogenesis, it is urgent to impede progression this disease improve diagnosis techniques. Ferroptosis, a form programmed cell death mechanistically distinct from apoptosis autophagy, implicated throughout pathogenesis infarction. Dysregulation protein translation leads abnormal expression, disruption cellular signaling, dysfunction, thereby disturbing normal function exacerbating progression. Consequently, clarifying mechanism dysregulation in ferroptosis during will enhance understanding In review, latest progress relationship between collected. The mechanisms by which they regulate are explored, current status role different stages introduced. These findings expected provide valuable insights for pathophysiological precise treatment.

Language: Английский

Citations

0
SLC7A11-HSPB1 Axis: A Novel Mechanism for Hepatocellular Carcinoma Progression and Ferroptosis Regulation DOI Creative Commons

Yan An,

Weilong Liu,

Yuliang Deng

et al.

Biomedical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 100869 - 100869

Published: May 1, 2025

Language: Английский

Citations

0
Carrageenan-ferrocene-eicosapentaenoic acid composite hydrogel induce ferroptosis and apoptosis for anti-tumor recurrence and metastasis DOI
Xiangyan Chen, Tianze Jiang,

Yantao Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133942 - 133942

Published: July 16, 2024

Language: Английский

Citations

3
Ferroptosis in radiation-induced brain injury: roles and clinical implications DOI Creative Commons
Lifang Li, Xia Liu,

Chunfeng Han

et al.

BioMedical Engineering OnLine, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 11, 2024

Language: Английский

Citations

3