European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(27)
Published: May 3, 2024
Abstract
This
review
aims
to
highlight
the
role
that
computational
chemistry
has
played
in
advancing
supramolecular
field.
We
demonstrated
recent
uses
of
methodologies
elucidate
noncovalent
interactions
various
processes
occurring
systems.
also
emphasized
contributions
these
techniques
studying
reactions
within
confined
space,
showing
how
help
clarify
effects
reactivity
and
conformational
locking.
Furthermore,
we
underscore
utilization
Molecular
Dynamics
(MD)
elucidating
dynamical
processes,
understanding
temperature
pressure
effects,
exploring
space
chemistry.
Finally,
impact
age
machine
learning
on
chemistry,
universal
approximators
can
enhance
existing
methods,
predict
properties,
efficiently
explore
chemical
encompassed
by
complex
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(5), P. 2118 - 2147
Published: April 25, 2024
The
various
kinds
of
nanocarriers
(NCs)
have
been
explored
for
the
delivery
therapeutics
designed
management
skin
manifestations.
NCs
are
considered
as
one
promising
approaches
attributable
to
sustained
release
and
enhanced
penetration.
Despite
extensive
applications
NCs,
challenges
in
their
via
barrier
(majorly
stratum
corneum)
persisted.
To
overcome
all
associated
with
microneedle
(MN)
technology
has
emerged
a
beacon
hope.
Programmable
drug
release,
being
painless,
its
minimally
invasive
nature
make
it
an
intriguing
strategy
circumvent
multiple
systems.
integration
positive
traits
MNs
boosts
therapeutic
effectiveness
by
evading
corneum,
facilitating
through
enhancing
targeted
delivery.
This
review
discusses
function
skin,
importance
MNs,
types
superiority
NC-loaded
MNs.
We
highlighted
NC-integrated
ailments,
combinational
delivery,
active
targeting,
vivo
imaging,
theranostics.
clinical
trials,
patent
portfolio,
marketed
products
drug/NC-integrated
covered.
Finally,
regulatory
hurdles
toward
benchtop-to-bedside
translation,
along
prospects
needed
scale
up
MN
technology,
deliberated.
current
is
anticipated
deliver
thoughtful
visions
researchers,
clinicians,
formulation
scientists
successful
development
MN-technology-based
product
carefully
optimizing
variables.
Cancer Pathogenesis and Therapy,
Journal Year:
2024,
Volume and Issue:
3(1), P. 30 - 47
Published: Jan. 12, 2024
Breast
cancer
(BC)
is
the
most
prevalent
in
women
globally.
Anti-cancer
advancements
have
enabled
killing
of
BC
cells
through
various
therapies;
however,
relapse
still
a
major
limitation
and
decreases
patient
survival
quality
life.
Epithelial-to-mesenchymal
transition
(EMT)
responsible
for
tumor
several
cancers.
This
highly
regulated
event
causes
phenotypic,
genetic,
epigenetic
changes
microenvironment
(TME).
review
summarizes
recent
regarding
EMT
using
de-differentiation
partial
theories.
We
extensively
mechanistic
pathways,
TME
components,
anti-cancer
adjuvant
neo-adjuvant
therapies
triggering
tumors.
Information
essential
clinical
studies
trials
also
discussed.
Furthermore,
we
highlight
strategies
targeting
pathways.
provides
holistic
picture
biology,
molecular
advances
therapeutic
strategies.
Macromolecular Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
This
article
explores
the
hierarchical
self-assembly
of
short
peptides,
which
refers
to
structured
spatial
arrangements
these
molecules
over
long
distances.
phenomenon
is
commonly
found
in
nature
and
has
important
implications
for
biological
structure
function.
Short
peptides
are
preferred
because
they
have
ability
spontaneously
create
various
nanostructures.
process,
known
as
bottom-up
assembly,
allows
addition
functional
groups
at
carboxyl
or
amine
ends
peptides.
These
enable
specific
functions
that
extremely
valuable
fields
biotechnology
biomedicine.
text
discusses
basic
processes
involved
such
characteristics
amino
acid
side
chains,
categorization
according
their
chemical
structure,
influence
intermolecular
forces,
dynamic
process.
In
addition,
paper
uses
disciplines
biomedicine
optoelectronics,
including
stimulus-responsive
hydrogels,
tissue
engineering,
drug
delivery.
The
also
suggests
rational
design
principles
controlling
creating
new
commercial
applications,
particularly
with
offers
insights
into
future
discipline.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
Multidrug
resistance
(MDR)
infectious
wounds
are
a
major
concern
due
to
drug
resistance,
leading
increased
patient
morbidity.
Lichenysin
(LCN),
lipopeptide
and
biosurfactant
obtained
from
certain
strains
of
Bacillus
licheniformis,
has
demonstrated
an
excellent
antimicrobial
property.
The
present
study
focuses
on
the
fabrication
comprehensive
evaluation
LCN-incorporated
poly(vinyl
alcohol)
(PVA)/polycaprolactone
(PCL)-based
nanofiber
scaffolds
using
electrospinning
technique
as
potential
wound
healing
biomaterial
for
treatment
MDR
in
diabetic
rats.
LCN-loaded
PVA–PCL
were
characterized
their
physicochemical,
antimicrobial,
vitro
cell
line
L-929,
hemocompatibility,
flow
cytometry,
vivo
healing,
enzyme-linked
immuno
sorbent
assay
(ELISA).
Morphological
analysis
via
scanning
electron
microscopy
(SEM)
images
confirmed
smooth
porous
nanofibers
with
diameters
range
200–300
nm.
Fourier
transform
infrared
X-ray
diffraction
(XRD)
results
structural
integrity,
chemical
compatibility,
amorphous
nature
developed
scaffolds.
loaded
LCN
water
retention,
moderate
biodegradability,
sustained
release
up
72
h.
Mechanical
characterization
robust
tensile
strength
conducive
applications.
Antimicrobial
activity
against
Pseudomonas
aeruginosa
(P.
aeruginosa)
Staphylococcus
aureus
(S.
aureus)
showed
substantial
antibacterial
antibiofilm
activity.
In
studies
enhanced
adhesion,
proliferation,
migration,
viability,
signifying
cytocompatibility
these
exceptional
These
findings
indicate
that
LCN-enriched
hold
significant
therapeutic
strategy
rats
through
multifaceted
approach.
