Black Sea Journal of Engineering and Science,
Journal Year:
2024,
Volume and Issue:
7(4), P. 752 - 755
Published: July 15, 2024
Kemik
dokusu
organik
ve
inorganik
bileşenlerden
oluşan
bir
yapıdır.
dokusunun
kırılmasıyla
ilgili
sorunlar
mevcuttur.
Kırığın
kaynaması
rehabilitasyon
süreci
çeşitli
nedenlerden
dolayı
uzun
zaman
almaktadır.
Yan
etkiler
arasında
kemik
kırıklarının
iyileşmesinde
gecikme,
kemiğin
kaynamaması
enfeksiyonlar
yer
alır.
Son
yıllarda
yapılan
çalışmalar
ortopedi
cerrahlarını
hücresel
tedaviye
biyomateryallere
yönlendirmiştir.
Çalışmamızda
kollajen,
lif
kabağı,
PRP
kondrosit
(kıkırdak
hücresi)
içeren
iskeleleri
in
vivo
iyileşme
açısından
araştırdık.
Çalışma
rastgele
4
gruba
ayrılan
12
adet
tavşan
üzerinde
gerçekleştirildi.
Tavşanlar
implantasyondan
8
hafta
sonra
yüksek
doz
anestezi
uygulanarak
sakrifiye
edildi.
Ameliyatından
8.
haftada
edilen
hayvanlardan
alınan
numuneler
histolojik
analiz
yapıldı.
Sonuçlarımız
kabağı+PRP+kondrosit
hücre
iskelelerinin
biyouyumlu
olduğunu
iyileştirme
mühendisliğine
mükemmel
alternatif
gösterdi.
Journal of Functional Biomaterials,
Journal Year:
2024,
Volume and Issue:
15(7), P. 178 - 178
Published: June 28, 2024
Zinc
is
known
for
its
role
in
enhancing
bone
metabolism,
cell
proliferation,
and
tissue
regeneration.
Several
studies
proposed
the
incorporation
of
zinc
into
hydroxyapatite
(HA)
to
produce
biomaterials
(ZnHA)
that
stimulate
accelerate
healing.
This
systematic
review
aimed
understand
physicochemical
characteristics
zinc-doped
HA-based
evidence
their
biological
effects
on
osteoblastic
cells.
A
comprehensive
literature
search
was
conducted
from
2022
2024,
covering
all
years
publications,
three
databases
(Web
Science,
PUBMED,
Scopus),
retrieving
609
entries,
with
36
articles
included
analysis
according
selection
criteria.
The
selected
provided
data
material’s
properties,
methods
incorporation,
ZnHA
production
typically
involves
wet
chemical
synthesis
HA
precursors,
followed
by
deposition
substrates
using
processes
such
as
liquid
precursor
plasma
spraying
(LPPS).
Characterization
techniques
confirmed
successful
lattice.
findings
indicated
at
low
concentrations
non-cytotoxic
beneficial
found
adhesion,
osteogenic
factors,
thereby
promoting
vitro
mineralization.
However,
optimal
concentration
desired
varied
across
studies,
making
it
challenging
establish
a
standardized
concentration.
materials
are
biocompatible
enhance
osteoblast
proliferation
differentiation.
mechanisms
release
ideal
regeneration
require
further
investigation.
Standardizing
these
parameters
essential
effective
clinical
application
ZnHA.
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Abstract
Acellular
dermal
matrix
(ADM)
shows
promise
for
cartilage
regeneration
and
repair.
However,
an
effective
decellularization
technique
that
removes
cellular
components
while
preserving
the
extracellular
matrix,
transformation
of
2D-ADM
into
a
suitable
3D
scaffold
with
porosity
enhancement
bioactive
biomechanical
properties
in
3D-ADM
are
yet
to
be
fully
addressed.
In
this
study,
we
present
innovative
method
involving
0.125%
trypsin
0.5%
SDS
1%
Triton
X-100
solution
preparing
ADM
converting
scaffolds.
These
scaffolds
exhibit
favorable
physicochemical
properties,
exceptional
biocompatibility
significant
potential
driving
vitro
vivo.
To
further
enhance
scaffolds,
incorporated
porcine-derived
small
intestinal
submucosa
(SIS)
bioactivity
calcium
sulfate
hemihydrate
(CSH)
reinforcement.
The
resulting
3D-ADM+SIS
displayed
heightened
biological
activity,
3D-ADM+CSH
notably
bolstered
strength.
Both
types
showed
repair
vivo,
considerable
improvements
observed
repairing
defects
within
rabbit
articular
model.
summary,
research
introduces
versatile
customizable
poised
revolutionize
field
regeneration.
Marine Drugs,
Journal Year:
2025,
Volume and Issue:
23(4), P. 151 - 151
Published: March 30, 2025
Bone
tissue
injuries
are
a
significant
health
risk,
and
their
repair
is
challenging.
While
various
materials
have
potential
for
bone
repair,
issues
like
sourcing
immune
rejection
limit
use.
Marine-derived
collagen,
abundant
free
from
religious
disease
transmission
concerns,
promising
biomaterial
in
engineering.
Cross-linking
modification
can
enhance
its
mechanical
properties
degradation
rate,
making
it
more
suitable
repair.
However,
detailed
analysis
of
cross-linking
methods,
property
changes
post-cross-linking,
impact
on
needed.
This
review
examines
marine
collagen’s
improved
characteristics,
providing
foundation
effective
use
Biomimetics,
Journal Year:
2024,
Volume and Issue:
9(7), P. 418 - 418
Published: July 8, 2024
Biomimetic
gels
are
synthetic
materials
designed
to
mimic
the
properties
and
functions
of
natural
biological
systems,
such
as
tissues
cellular
environments.
This
manuscript
explores
advancements
future
directions
injectable
biomimetic
in
biomedical
applications
highlights
significant
potential
hydrogels
wound
healing,
tissue
regeneration,
controlled
drug
delivery
due
their
enhanced
biocompatibility,
multifunctionality,
mechanical
properties.
Despite
these
advancements,
challenges
resilience,
degradation
rates,
scalable
manufacturing
remain.
discusses
ongoing
research
optimize
properties,
develop
cost-effective
production
techniques,
integrate
emerging
technologies
like
3D
bioprinting
nanotechnology.
Addressing
through
collaborative
efforts
is
essential
for
unlocking
full
engineering
regenerative
medicine.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101737 - 101737
Published: April 1, 2025
Osteochondral
scaffolds
designed
with
bi-phasic
and
multi-phasic
have
typically
struggled
post-implantation
delamination.
To
address
this
issue,
we
developed
a
novel
integrated
scaffold
natural
continuous
interface
heterogeneous
bilayer
structure.
Through
layer-by-layer
wet
electrospinning,
two-dimensional
(2D)
bi-layer
membranes
of
silk
fibroin
(SF)
polycaprolactone
(PCL)
were
fabricated.
These
then
transformed
into
three-dimensional
(3D)
using
CO2
gas
foaming
technique,
followed
by
gelatin
coating
on
the
osteogenic
layer
to
afford
final
porous
scaffolds.
In
vitro
studies
indicated
that
3D
better-maintained
cell
phenotypes
than
conventional
2D
electrospun
films.
Additionally,
showed
superior
cartilage
repair
osteoinductivity
potential,
increased
subchondral
bone
volume
reduced
defect
area
in
rat
osteochondral
defects
models
at
12
weeks.
Taken
together,
these
gas-foamed
promising
candidate
for
regeneration.
