Surgeries,
Journal Year:
2024,
Volume and Issue:
5(3), P. 640 - 659
Published: Aug. 9, 2024
The
skin
is
crucial
for
homeostasis
and
body
defense,
requiring
quick
healing
to
maintain
internal
balance.
Initially
used
bone
repair,
calcium
hydroxyapatite
(HAp)
now
being
studied
soft
tissue
engineering.
This
literature
review
investigated
HAp’s
role
in
repair
through
searches
on
PubMed,
Scopus
(Elsevier),
Science
Direct,
Springer
Link,
Google
Scholar
databases
without
time
restrictions,
using
keywords
“hydroxyapatite
AND
wound”
repair”.
Inclusion
criteria
encompassed
vivo
studies
humans
animals,
English
publications,
full
access,
sufficient
data
repair.
Exclusions
included
duplicates,
unrelated
articles,
editor
letters,
reviews,
comments,
conference
abstracts,
dissertations,
theses.
Out
of
the
472
articles
initially
identified,
139
met
inclusion
criteria,
with
21
focusing
HAp
Findings
indicate
that
nano-HAp
regeneration
are
promising,
especially
when
combined
other
biomaterials,
offering
antimicrobial
anti-inflammatory
benefits
stimulating
angiogenesis.
suggests
their
potential
application
dermatology,
surgery,
dentistry,
extending
versatility
from
hard
tissues
enhancing
critical
properties
accelerating
healing.
Journal of Biomaterials Science Polymer Edition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 31
Published: April 17, 2025
Although
the
skin
has
a
high
healing
capacity,
severe
wounds
often
require
external
interventions
to
heal
properly.
Tissue-engineered
wound
dressings
have
indeed
gained
significant
attention
among
various
treatment
strategies
for
healing.
This
study
focuses
on
integration
of
polyvinyl
pyrrolidone
(PVP),
quaternized
chitosan
(QCS),
and
dextran
(DEX)
prepare
ternary
composite
(PVP/QCS/DEX)
as
dressing
hydrogels
with
varying
concentration
PVP
DEX.
A
variety
analytical
methods,
including
infrared
spectroscopy
(FTIR),
scanning
electron
microscopy
(SEM),
contact
angle,
water
vapor
transmission
rate
(WVTR)
were
employed
assess
characteristics
samples.
The
uniform
interconnected
porous
structure
samples
was
confirmed
by
SEM
results.
All
showed
porosity
transition
rate,
demonstrating
their
ability
provide
suitable
moist
environment
efficient
exudate
handling
antibacterial
test
conducted
demonstrated
activity
drug-loaded
hydrogel
Escherichia
coli
Staphylococcus
aureus.
in
vitro
cytotoxicity
evaluation
using
MTT
assay
that
developed
PVP/QCS/DEX
exhibit
satisfactory
cytocompatibility
promote
cell
viability.
results
scratch
indicated
had
promoted
migration
would
improve
accelerate
process.
vivo
tests
sample
revealed
promising
performance.
Therefore,
based
favorable
performance
observed
throughout
analysis,
as-prepared
show
promise
field
dressings.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 5, 2024
Burns
usually
result
in
damage
and
loss
of
skin
forming
irregular
wound
wounds.
The
lack
tissue
protection
makes
the
site
highly
vulnerable
to
bacterial
infections,
hindering
healing
process.
However,
commonly
used
dressings
do
not
readily
provide
complete
coverage
wounds
compared
regular
Therefore,
there
is
an
urgent
need
prepare
a
dressing
with
high
antimicrobial
efficacy
for
administration
drugs
In
this
study,
chitosan
(CS)/polyvinylpyrrolidone
(PVP)
composite
nanofiber
membrane
(CS/PVP/Phlorizin)
loaded
root
bark
glycosides
(Phlorizin)
was
developed
using
electrostatic
spinning
technique.
incorporation
phlorizin,
natural
antioxidant,
into
fiber
membranes
notably
boosted
their
antioxidant
capabilities,
along
demonstrating
excellent
hydrophilic
characteristics.
Carbohydrate Polymer Technologies and Applications,
Journal Year:
2024,
Volume and Issue:
8, P. 100532 - 100532
Published: June 15, 2024
Bovine
mastitis
is
a
global
problem
and
mainly
treated
with
antimicrobial
agents
that
can
significantly
affect
milk
quality
threaten
human
health.
The
mammary
gland
be
damaged
by
the
accumulation
of
reactive
oxygen
species
(ROS),
particularly
during
perinatal
period.
Dihydromyricetin
(DHM)
has
wide
range
pharmacological
activities
considered
safe.
However,
its
poor
solubility,
absorption,
bioavailability
have
limited
application.
To
address
this
issue,
we
designed
synthesized
new
chitosan-derivative
nanoparticles
(HACC-NPs)
loaded
DHM,
which
potential
to
overcome
bioabsorption
problems
enhance
antibacterial
antioxidant
effects.
We
used
emulsification/crosslinking
method
load
DHM
into
(DHM/HACC-NPs);
then,
SEM,
TEM
FTIR
analyses
were
show
denser,
more
tightly
packed
matrix
for
DHM/HACC-NPs,
successfully
prepared.
size
(176.4
nm),
polydispersity
index
(PDI,
0.21),
absolute
value
zeta
(+26.3
mV)
confirmed
stability
DHM/HACC-NPs.
More
importantly,
DHM/HACC-NPs
had
stronger
effect
on
S.
aureus
(MIC
=
0.52
mg/mL
MBC
1.02
mg/mL)
than
E.
coli
2.05
mg/mL).
Notably,
concentration-dependent
scavengers
DPPH
hydroxyl
radicals.
In
summary,
exhibited
superior
biocompatibility
activities,
offering
insights
development
robust,
udder-stable
drug
platform
as
promising
strategy
treating
dairy
cow
mastitis.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(13), P. 3136 - 3136
Published: July 1, 2024
Dihydromyricetin
(DMY)
has
been
encapsulated
in
delivery
systems
to
address
the
solubility
limitations
of
DMY
water
and
improve
its
bioavailability.
Air-assisted
electrospinning
used
as
a
novel
technology
load
DMY.
To
evaluate
impact
adding
dextran/zein
nanofibers
understand
effects
Maillard
reaction
(MR)
on
physical
functional
properties
DMY-loaded
nanofibers,
dextran/zein/xylose
with
0%,
1%,
2%,
3%,
4%
were
fabricated,
followed
by
MR
crosslinking.
Scanning
electron
microscopy
(SEM)
observations
indicated
that
addition
did
not
affect
morphology
nanofibers.
X-ray
diffraction
(XRD)
results
amorphous
dispersion
within
decreased
crystalline
structure
following
MR,
which
might
their
molecular
flexibility.
The
nanofibrous
film
formed
after
exhibited
both
increased
tensile
strength
elastic
modulus
due
hydrogen
bonding
elongation
at
break
attributed
amorphization
also
found
exhibit
improved
heat
stability
MR.
antioxidant
activity
dose-dependent
effect
radical
scavenging
reducing
power.
maintenance
suggested
during
treatment.
Overall,
various
contents
tunable
effective
activities,
indicating
offer
successful
system,
can
be
further
applied
an
active
package.
