In Situ Crosslinked Biodegradable Hydrogels Based on Poly(Ethylene Glycol) and Poly(ε-Lysine) for Medical Application DOI Creative Commons
Xia Ding, Bing Yang, Zhaosheng Hou

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5435 - 5435

Published: Nov. 18, 2024

Hydrogels have emerged as promising biomaterials due to their excellent performance; however, biocompatibility, biodegradability, and absorbability still require improvement support a broader range of medical applications. This paper presents new biofunctionalized hydrogel based on in situ crosslinking between maleimide-terminated four-arm-poly(ethylene glycol) (4-arm-PEG-Mal) poly(ε-lysine) (ε-PL). The PEG/ε-PL hydrogels, named LG-n, were rapidly formed via amine/maleimide reaction by mixing 4-arm-PEG-Mal ε-PL under physiological conditions. corresponding dry gels (DLG-n) obtained through freeze-drying technique.

Language: Английский

Biodegradable and antibacterial edible films based on egg yolk granules/gelatin/CMC with e-poly-l-lysine: Application in fresh chicken meat preservation DOI

Muhammad Moeid Khan,

Shuguo Sun, Ran Shi

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 478, P. 143627 - 143627

Published: March 5, 2025

Language: Английский

Citations

2
Synergistic Functions of the Janus Fibrous Membrane for Enhanced Bone Repair DOI
Tingting Zhang, Jinghong Yang, Yu Lu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

The treatment of bone defects presents significant challenges in clinical practice. Guided regeneration (GBR) strategies offer a new approach, but existing commercial GBR membranes still lack optimal barrier and osteogenic functions. This study the design Janus fibrous membrane using classic amphiphilic block copolymers gelatin methacryloyl containing unsaturated double bonds through gradient electrospinning process. Specifically, by controlling parameters, self-assembly copolymers, secondary photo-cross-linking, differential composition, topological structure, properties between different layers were achieved, thereby realizing synergistic physiological repair-promoting By leveraging effect, it effectively blocks adverse effects soft tissue cell ingrowth on repair while guiding proliferation differentiation. Furthermore, membrane's functionality is optimized incorporating antimicrobial component ε-poly-l-lysine niobium. In vivo studies demonstrate excellent biocompatibility, antibacterial activity, remarkable potential both normal infectious defect animal models. developed serves as versatile platform for biomedical applications, offering vast to address limitations current treatment.

Language: Английский

Citations

1
Enhancing elemental release and antibacterial properties of resin-based dental sealants with calcium phosphate, bioactive glass, and polylysine DOI Creative Commons

Phatpicha Lertwisitphon,

Yotsavee Worapasphaiboon,

Nichapa Champakanan

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 18, 2025

This study aimed to develop ion-releasing and antibacterial resin-based dental sealants comprising 3 6 wt% monocalcium phosphate monohydrate (MCPM, M), bioactive glass (BAG, B), polylysine (PLS, P). The physical properties, mechanical performance, cytotoxicity, inhibition of S. mutans biofilm by these materials were subsequently evaluated. Five experimental formulated as follows: F1 (M6B6P6), F2 (M6B6P3), F3 (M3B3P6), F4 (M3B3P3), F5 (M0B0P0, serving the control). ClinproXT (CP, M, Saint Paul, MN, USA) was used for commercial comparison. degree monomer conversion (DC) determined using attenuated total reflectance-Fourier transform infrared spectroscopy (n = 5). biaxial flexural strength 6) Vickers surface microhardness 5) evaluated after a 24-hour immersion in water. element release over 4 weeks measured inductively coupled plasma-optical emission spectrometry (ICP-OES) 3). cell viability mouse fibrosarcoma cells exposed extract assessed via an MTT assay Additionally, tested Statistical analysis conducted one-way ANOVA Tukey HSD test. lowest DC among obtained from (66 ± 4%), which significantly higher than CP (54 2%, p < 0.001). (131 47 MPa). comparable that (140 58 MPa, 0.992). detected with (19 2 hardness number), (12 1 number, 0.003). Furthermore, high > 90% exposure extracts detected, similar observed CP. exhibited Ca P compared showed potential trend reducing formation. Increasing additive concentrations minimal effects on material except enhanced elemental slight reduction BFM PLS content. provided sufficient maintained bacterial product.

Language: Английский

Citations

0
Dendrimers as Versatile Platforms for Advanced Biosensor Development: A Review on Chemistry, Synthesis, and Performance Enhancements DOI

Fatemeh Aminian,

Alireza Hemmati

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 116365 - 116365

Published: April 1, 2025

Language: Английский

Citations

0
Recent Developments in Antimicrobial and Antiviral Agents Based on Natural/Synthetic Polymers and Dendrimers: Design and Therapeutic Applications DOI
Ahmad Abd‐El‐Aziz, Moustafa M.G. Fouda, Carmen M. Sharaby

et al.

Macromolecular Chemistry and Physics, Journal Year: 2024, Volume and Issue: 225(17)

Published: May 28, 2024

Abstract This review article explores the recent innovations in field of antimicrobial and antiviral macromolecules. With rising challenge antibiotic resistance, as well overuse antibiotics, there is a growing demand for efficient solutions to combat microbial viral infections. The development new effective agents highlighted. designed give comprehensive view literature focusing on few examples combating infections each section. A brief description naturally occurring organic‐based materials that exhibit and/or activities presented, polysaccharides, peptides, proteins. Synthetic are divided into subsections including polymers, dendrimers, nanomaterials. synthesis applications inorganic such polyphosphazenes polysiloxanes, tin‐, germanium‐ gallium‐based emphasized this review. Organometallic macromolecules also described, their examined. Overall, provides overview advancements design macromolecules, offering valuable insights potential biomedical research drug‐resistant microorganisms viruses.

Language: Английский

Citations

3
One-Step Synthesis of Antimicrobial Polypeptide-Selenium Nanoparticles Exhibiting Broad-Spectrum Efficacy against Bacteria and Fungi with Superior Resistance Prevention DOI
Tao Huang, Denver P. Linklater, Xin Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

The growing threat of antimicrobial resistance (AMR) necessitates innovative strategies beyond conventional antibiotics. In response, we developed a rapid one-step method to sythesize peptide (AMP) ε-poly-

Language: Английский

Citations

2
Enhanced ε-Poly-L-Lysine Production in Streptomyces albulus through Multi-Omics-Guided Metabolic Engineering DOI Creative Commons
Liang Wang, Hao Yang,

Mengping Wu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 752 - 752

Published: June 25, 2024

Safe and eco-friendly preservatives are crucial to preventing food spoilage illnesses, as foodborne diseases caused by pathogens result in approximately 600 million cases of illness 420,000 deaths annually. ε-Poly-L-lysine (ε-PL) is a novel preservative widely used many countries. However, its commercial application has been hindered high costs low production. In this study, ε-PL’s biosynthetic capacity was enhanced Streptomyces albulus WG608 through metabolic engineering guided multi-omics techniques. Based on transcriptome metabolome data, differentially expressed genes (fold change >2 or <0.5; p < 0.05) metabolites >1.2 <0.8) were separately subjected gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analysis. The integrative analysis transcriptome, metabolome, overexpression revealed the essential roles isocitrate lyase, succinate dehydrogenase, flavoprotein subunit, diaminopimelate polyphosphate kinase, polyP:AMP phosphotransferase ε-PL biosynthesis. Subsequently, strain with ATP supply, L-lysine synthetase expression constructed improve Finally, resulting strain, S. WME10, achieved an production rate 77.16 g/L 5 L bioreactor, which highest reported date. These results suggest that can facilitate identification key pathways genetic elements affecting synthesis, guiding further thus significantly enhancing method presented study could be applicable other valuable natural antibacterial agents.

Language: Английский

Citations

1
Micro-wave induced pyrolysis of low density polyethylene (LDPE) and biodegradation of resulting wax in soil and by defined microbial consortia is closing the loop towards LDPE upcycling DOI
Olivia A. Attallah, Pablo Ferrero, Marija Lješević

et al.

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(6), P. 114269 - 114269

Published: Sept. 26, 2024

Language: Английский

Citations

1
The Promising Application of Pectin/ɛ-Polylysine as Coating Materials on Anodized Titanium Surfaces for Orthopedic Implants: Preparation, Characterization and Biomedical Properties DOI
Farnaz Heidari Laybidi, Abbas Bahrami, Mohammad Saeid Abbasi

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 704, P. 135517 - 135517

Published: Oct. 6, 2024

Language: Английский

Citations

0
In Situ Crosslinked Biodegradable Hydrogels Based on Poly(Ethylene Glycol) and Poly(ε-Lysine) for Medical Application DOI Creative Commons
Xia Ding, Bing Yang, Zhaosheng Hou

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5435 - 5435

Published: Nov. 18, 2024

Hydrogels have emerged as promising biomaterials due to their excellent performance; however, biocompatibility, biodegradability, and absorbability still require improvement support a broader range of medical applications. This paper presents new biofunctionalized hydrogel based on in situ crosslinking between maleimide-terminated four-arm-poly(ethylene glycol) (4-arm-PEG-Mal) poly(ε-lysine) (ε-PL). The PEG/ε-PL hydrogels, named LG-n, were rapidly formed via amine/maleimide reaction by mixing 4-arm-PEG-Mal ε-PL under physiological conditions. corresponding dry gels (DLG-n) obtained through freeze-drying technique.

Language: Английский

Citations

0