Biomedical Materials,
Journal Year:
2025,
Volume and Issue:
20(2), P. 025035 - 025035
Published: Feb. 28, 2025
Abstract
Antibacterial
nanofibers
have
been
widely
used
in
the
fields
of
biomedicine
and
food
packaging
fields.
To
overcome
existing
antibiotic
resistance,
this
study
utilized
isobavachalcone
(IBC),
a
natural
compound
with
antibacterial
antioxidant
properties,
combined
polycaprolactone
(PCL)
gelatin
(GEL)
to
develop
an
electrospun
nanofibrous
membrane.
Scanning
electron
microscopy
(SEM)
analysis
revealed
uniform
smooth
surface
structure
nanofiber.
Fourier
transform
infrared
spectroscopy
x-ray
diffraction
confirmed
interactions
among
components
membrane
PCL/GEL/IBC
(PGI).
Thermogravimetric
contact
angle
measurements
demonstrated
thermal
stability
hydrophilic
nature.
Additionally,
mechanical
properties
PGI
were
that
elongation
at
break
increased
19.9%
tensile
strength
2.9
MPa.
In
vitro
release
studies
indicated
least
48%
rate
IBC
from
12
h,
period
up
14
d.
Antioxidant
results
membranes
had
fine
abilities
for
scavenging
free
radical.
The
elimination
over
99%
Staphylococcus
aureus
54%
Candida
albicans
capacities
membrane,
indicating
its
potential
as
materials.
Subsequent
faster
wound
healing,
lower
oxidative
damage
4-HNE
8-OHdG,
further
can
reduce
promote
healing.
These
findings
also
suggest
field
tissue
engineering.
Device-associated
infections
are
a
major
challenge
for
healthcare
and
cause
patient
morbidity
mortality
as
well
pose
significant
economic
burden.
Infection-causing
bacteria
fungi
equally
notorious
responsible
biofilm
formation
the
development
of
antibiotic
antifungal-resistant
strains.
Biomaterials
resisting
bacterial
fungal
adhesion
can
address
device-associated
more
safely
efficiently
than
conventional
systemic
therapies.
Herein,
we
present
combination
potent
antibacterial
nitric
oxide
(NO)
with
antifungal
fluconazole
codelivery
system
from
polymeric
matrix
to
combat
simultaneously.
The
NO
donor
S-nitroso-N-acetyl-penicillamine
(SNAP)-blended
low-water-uptake
polycarbonate
urethane
(TSPCU)
was
dip-coated
high-water-uptake
polyether
(TPU)
containing
have
an
surface.
composites
were
characterized
surface
wettability
coating
stability
using
water
contact
angle
(WCA)
analysis.
real-time
release
(72
h)
evaluated
chemiluminescence-based
analyzer
which
showed
physiologically
relevant
levels
released.
released
72
h
under
physiological
conditions.
Antibacterial
analysis
demonstrated
>
3-log
reduction
viable
Staphylococcus
aureus
>2-log
Escherichia
coli
compared
controls.
evaluation
resulted
in
∼98%
adhered
∼92%
planktonic
Candida
albicans.
SNAP-fluconazole
also
biocompatibility
against
mouse
fibroblast
cells.
This
novel
preventative
strategy
may
offer
promising
tool
further
translational
research.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 15, 2025
Abstract
Blending
poly
(lactic
acid)
(PLA)
with
(vinyl
alcohol)
(PVA)
improves
the
strength
and
hydrophilicity
of
nanofibers,
making
them
suitable
for
biomedical
applications
like
wound
dressings.
This
study
explores
how
electrospinning
parameters—applied
voltage,
flow
rate,
needle-to-collector
distance—affect
PVA/PLA
nanofiber
properties,
optimizing
using
a
Taguchi
design
experiment
(DoE)
approach
to
enhance
their
mechanical
surface
properties
clinical
use.
Given
high
costs
time
associated
conducting
extensive
experimental
tests,
an
artificial
neural
network
based
surrogate
model
is
developed
predict
outcomes
more
efficiently,
facilitating
faster
identification
optimal
configurations.
Analysis
Variance
reveals
rate
as
most
significant
determinant
fiber
diameter.
The
configuration
yields
nanofibers
average
diameter
127.6
±
19.8
nm.
These
fibers
exhibit
exceptional
tensile
strength,
flexibility,
water
contact
angle
37°,
demonstrating
superior
conducive
cell
adhesion
proliferation—key
factors
in
promoting
healing.
Comparative
analyses
confirm
that
optimized
scaffold
(18
cm
distance,
0.6
ml/h
18
kV
applied
voltage)
significantly
outperforms
alternative
configurations,
such
10
1.2
22
which
display
larger
diameters,
reduced
(contact
72°),
diminished
suitability
medical
Validation
experiments
affirm
accuracy
reproducibility
optimization,
substantiating
methodological
rigor
reliability
findings.
work
contributes
novel
insights
into
tunable
electrospun
providing
pathway
developing
advanced
dressings
facilitate
tissue
integration
accelerate
have
potential
revolutionize
care
by
offering
cost-effective
clinically
viable
solution
enhancing
patient
recovery,
reducing
treatment
durations,
improving
global
healthcare
outcomes.
IGI Global eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 289 - 326
Published: April 11, 2025
Nanofiber
technology
presents
significant
potential
across
various
medical
applications,
with
particular
emphasis
on
its
role
in
wound
healing.
This
chapter
examines
the
ability
of
nanofibers
to
mimic
extracellular
matrix,
facilitating
critical
processes
such
as
cell
adhesion,
migration,
nutrient
and
oxygen
delivery,
inflammation
modulation,
controlled
release
bioactive
molecules.
These
properties
position
optimal
candidates
for
advanced
dressings,
biodegradable
scaffolds,
cell-seeded
constructs.
Empirical
studies
substantiate
their
efficacy
mitigating
inflammation,
preventing
infections,
minimizing
scar
formation.
However,
challenges
persist,
including
issues
related
scalability,
cost-effectiveness,
mechanical
stability,
biocompatibility,
regulatory
approval.
concludes
by
addressing
these
outlining
research
gaps
that
must
be
bridged
fully
harness
nanofiber
technology,
particularly
long-term
safety,
mechanistic
insights,
adaptation
low-resource
settings.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(20), P. 2853 - 2853
Published: Oct. 10, 2024
Tissue
engineering
has
great
potential
for
the
restoration
of
damaged
tissue
due
to
injury
or
disease.
During
development,
scaffolds
provide
structural
support
cell
growth.
To
grow
healthy
tissue,
principal
components
such
must
be
biocompatible
and
nontoxic.
Poly(ε-caprolactone)
(PCL)
is
a
biopolymer
that
been
used
as
key
component
composite
applications
its
mechanical
strength
biodegradability.
However,
PCL
alone
can
have
low
adherence
wettability.
Blends
biomaterials
incorporated
achieve
synergistic
scaffold
properties
engineering.
Electrospun
PCL-based
consist
single
blended-composition
nanofibers
with
multi-layered
internal
architectures
(i.e.,
core-shell
nanofibers).
Nanofiber
diameter,
composition,
properties,
biocompatibility,
drug-loading
capacity
are
among
tunable
electrospun
scaffolds.
Scaffold
including
wettability,
strength,
biocompatibility
further
enhanced
layering,
surface
modification,
coating
techniques.
In
this
article,
we
review
nanofibrous
fabrication
in
reported
recent
literature.
