Alginate-Based Electrospun Nanofibers and the Enabled Drug Controlled Release Profiles: A Review

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 789 - 789

Published: July 3, 2024

Alginate is a natural polymer with good biocompatible properties and potential polymeric material for the sustainable development replacement of petroleum derivatives. However, non-spinnability pure alginate solutions has hindered expansion applications. With continuous electrospinning technology, synthetic polymers, such as PEO PVA, are used co-spinning agents to increase spinnability alginate. Moreover, coaxial, parallel Janus, tertiary other diverse novel electrospun fiber structures prepared by multi-fluid have found new breakthrough problem poor spinning polymers. Meanwhile, effectively achieve multiple release modes drugs. The powerful combination electrostatic widely in many biomedical fields, tissue engineering, regenerative bioscaffolds, drug delivery, research fever continues climb. This particularly true controlled delivery aspect review provides brief overview alginate, introduces advances spinning, highlights progress alginate-based nanofibers achieving various modes, pulsed release, sustained biphasic responsive targeted release.

Language: Английский

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Electrospun multi-functional medicated tri-section Janus nanofibers for an improved anti-adhesion tendon repair

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 492, P. 152359 - 152359

Published: May 18, 2024

Language: Английский

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Engineered beads-on-a-string nanocomposites for an improved drug fast-sustained bi-stage release

Nanocomposites, Journal Year: 2024, Volume and Issue: 10(1), P. 240 - 253

Published: June 12, 2024

Language: Английский

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Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: June 13, 2024

Combination therapy with oral administration of several active ingredients is a popular clinical treatment for cancer. However, the traditional method has poor convenience, less safety, and low efficiency patients. The combination pharmaceutical techniques advanced material conversion methods can provide new solutions to this issue. In research, kind hybrid film was created via coaxial electrospraying, followed by casting process. films were composed Reglan 5-fluorouracil (5-FU)-loaded cellulose acetate (CA) core-shell particles in polyvinylpyrrolidone (PVP) matrix. Microscopic observations these demonstrated solid cross section loaded particles. X-ray diffraction Fourier-transform infrared tests verified that 5-FU showed amorphous states fine compatibilities polymeric matrices, i.e., PVP CA, respectively. vitro dissolution indicated able desired asynchronous dual-drug delivery, fast release Reglan, sustained 5-FU. controlled mechanisms shown be an erosion mechanism typical Fickian diffusion protocols reported herein pioneer approach fabricating biomaterials multiple drugs, each its own behavior, synergistic cancer treatment.

Language: Английский

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Reverse Gradient Distributions of Drug and Polymer Molecules within Electrospun Core–Shell Nanofibers for Sustained Release

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9524 - 9524

Published: Sept. 1, 2024

Core–shell nanostructures are powerful platforms for the development of novel nanoscale drug delivery systems with sustained release profiles. Coaxial electrospinning is facile and convenient creating medicated core–shell elaborate designs which sustained-release behaviors molecules can be intentionally adjusted. With resveratrol (RES) as a model poorly water-soluble cellulose acetate (CA) PVP polymeric carriers, brand-new electrospun nanostructure was fabricated in this study. The guest RES host CA were designed to have reverse gradient distribution within nanostructures. Scanning electron microscope transmission evaluations verified that these nanofibers had linear morphologies, without beads or spindles, an obvious double-chamber structure. X-ray diffraction patterns Fourier transform infrared spectroscopic results indicated involved components highly compatible presented amorphous molecular state. In vitro dissolution tests new structures able prevent initial burst release, extend continuous-release time period, reduce negative tailing-off effect, thus ensuring better profile than traditional blended drug-loaded nanofibers. mechanism underlying influence structure RES/CA on proposed. Based proof-of-concept demonstration, series advanced functional nanomaterials similarly developed based distributions multi-chamber

Language: Английский

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Electrospun chitosan//ethylcellulose-vitamin E//ethylcellulose-curcumin tri-chamber eccentric Janus nanofibers for a joint antibacterial and antioxidant performance

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 135753 - 135753

Published: Oct. 17, 2024

Language: Английский

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Versatile Hyper-Cross-Linked Polymers Derived from Waste Polystyrene: Synthesis, Properties, and Intentional Recycling

Langmuir, Journal Year: 2024, Volume and Issue: 40(32), P. 16670 - 16689

Published: June 24, 2024

Waste polystyrene contributes considerably to environmental pollution due its persistent nature, prompting a widespread consensus on the urgent need for viable recycling solutions. Owing aromatic groups structure of polystyrene, hyper-cross-linked polymers can be synthesized through Friedel–Crafts cross-linking reaction using Lewis acids as catalysts. In addition, and carbonaceous counterparts used in several important applications, which helps their efficient recycling. This review systematically explores methods preparing multifunctional from waste applications sustainable We have comprehensively outlined various synthetic approaches these investigated physical chemical properties. These not only exhibit structural flexibility but also demonstrate diversity performance, making them suitable applications. Through systematic examination methods, we showcase cutting-edge positions materials field polymers. Additionally, provide in-depth insights into potential intentional recycling, highlighting contributions protection development. research provides valuable references fields science management, encouraging further exploration innovative utilization discarded polystyrene.

Language: Английский

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Synergistic Effects of Radical Distributions of Soluble and Insoluble Polymers within Electrospun Nanofibers for an Extending Release of Ferulic Acid

Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2614 - 2614

Published: Sept. 15, 2024

Polymeric composites for manipulating the sustained release of an encapsulated active ingredient are highly sought after many practical applications; particularly, water-insoluble polymers and core–shell structures frequently explored to manipulate behaviors drug molecules over extended time period. In this study, electrospun nanostructures were utilized develop a brand-new strategy tailor spatial distributions both insoluble polymer (ethylcellulose, EC) soluble (polyvinylpyrrolidone, PVP) within nanofibers, thereby extended-release loaded ingredient, ferulic acid (FA). Scanning electron microscopy transmission assessments revealed that all prepared nanofibers had linear morphology without beads or spindles, those from coaxial processes obvious structure. X-ray diffraction attenuated total reflectance Fourier transform infrared spectroscopic tests confirmed FA fine compatibility with EC PVP, presented in amorphous state. vitro dissolution indicated radical (decreasing shell core) PVP (increasing able play their important role elaborately. On one hand, F3 advantages homogeneous composite F1 higher content solutions inhibit initial burst provide longer period release. other F2 core negative tailing-off The key element was water permeation rates, controlled by ratios polymers. new based on structure paves way developing wide variety polymeric heterogeneous realizing desired functional performances.

Language: Английский

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Medicated tri-layer fibers based on cellulose acetate and polyvinylpyrrolidone for enhanced antibacterial and wound healing properties

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122856 - 122856

Published: Oct. 10, 2024

Language: Английский

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Advanced applications of smart electrospun nanofibers in cancer therapy: With insight into material capabilities and electrospinning parameters

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100265 - 100265

Published: June 26, 2024

Cancer remains a major global health challenge, and despite available treatments, its prognosis poor. Recently, researchers have turned their attention to intelligent nanofibers for cancer drug delivery. These exhibit remarkable capabilities in targeted controlled release. Their inherent characteristics, such as high surface area-to-volume ratio, make them attractive candidates delivery applications. Smart can release drugs response specific stimuli, including pH, temperature, magnetic fields, light. This unique feature not only reduces side effects but also enhances the overall efficiency of systems. Electrospinning, widely used method, allows precision fabrication smart nanofibers. Its advantages include efficiency, user-friendliness, ability control various manufacturing parameters. In this review, we explore latest developments producing electrospun treatment. Additionally, discuss materials these critical parameters involved electrospinning process.

Language: Английский

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