Food & Function,
Journal Year:
2024,
Volume and Issue:
15(20), P. 10434 - 10446
Published: Jan. 1, 2024
Non-digestible
oligosaccharides
are
known
to
exert
health-promoting
effects.
However,
the
specific
mechanisms
by
which
they
regulate
host
physiology
remain
unclear.
Understanding
these
will
facilitate
development
of
non-digestible
oligosaccharide
compositions
that
can
achieve
synergistic
This
study
selected
three
representative
oligosaccharides,
namely
xylo-oligosaccharides
(XOS),
galacto-oligosaccharides
(GOS),
and
isomalto-oligosaccharides
(IMO),
investigate
their
effects
as
dietary
interventions
on
mice
fed
a
high-fat
diet.
The
results
demonstrated
XOS
IMO
synergistically
mitigated
weight
gain
ectopic
lipid
deposition.
Further
analysis
revealed
significantly
altered
composition
gut
microbiota,
while
enhanced
insulin
sensitivity
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(17), P. 2838 - 2838
Published: Aug. 24, 2024
The
gut
microbiota
constitutes
a
complex
ecosystem,
comprising
trillions
of
microbes
that
have
co-evolved
with
their
host
over
hundreds
millions
years.
Over
the
past
decade,
growing
body
knowledge
has
underscored
intricate
connections
among
diet,
microbiota,
and
human
health.
Bioactive
polysaccharides
(BPs)
from
natural
sources
like
medicinal
plants,
seaweeds,
fungi
diverse
biological
functions
including
antioxidant,
immunoregulatory,
metabolic
activities.
Their
effects
are
closely
tied
to
which
metabolizes
BPs
into
health-influencing
compounds.
Understanding
how
interact
is
critical
for
harnessing
potential
health
benefits.
This
review
provides
an
overview
focusing
on
its
role
in
diseases
obesity,
type
II
diabetes
mellitus,
non-alcoholic
fatty
liver
disease,
cardiovascular
diseases.
It
explores
basic
characteristics
several
impact
microbiota.
Given
significance
health,
we
summarize
these
BPs,
particularly
terms
immunoregulatory
activities,
blood
sugar,
hypolipidemic
effect,
thus
providing
valuable
reference
understanding
benefits
treating
These
properties
make
promising
agents
preventing
comprehensive
mechanisms
by
exert
through
opens
new
avenues
developing
targeted
therapies
improve
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 25, 2024
The
great
potential
of
polysaccharides
in
immunological
regulation
has
recently
been
highlighted
pharmacological
and
clinical
studies.
Polysaccharides
can
trigger
immunostimulatory
responses
through
molecular
identification,
intra-
intercellular
communication
via
direct
or
indirect
interactions
with
the
immune
system.
Various
their
derivative
compounds
interacts
at
cellular
level
to
boost
system,
including
arabinogalactans,
fucoidans,
mannans,
xylans,
galactans,
hyaluronans,
fructans,
pectin
etc.
These
natural
are
derived
from
various
plants,
animals
microbes.
A
unique
structural
diversity
identified
polysaccharides,
while
monosaccharides
glucosidic
bonds
mainly
confer
diverse
biological
activities.
improve
antioxidant
capacity,
reduce
production
pro-inflammatory
mediators,
strengthen
intestinal
barrier,
influence
composition
microbial
populations
promote
synthesis
short-chain
fatty
acids.
also
known
excessive
inflammatory
responses.
It
is
crucial
develop
polysaccharide-based
immunomodulators
that
could
be
used
prevent
treat
certain
diseases.
This
review
highlights
features,
immunomodulatory
properties,
underlying
mechanisms
naturally
occurring
activities
related
effects
by
elucidating
a
complex
relationship
between
immunity.
In
addition,
future
these
molecules
as
components
transform
pharmaceutical
applications
will
highlighted.
Nutrients,
Journal Year:
2024,
Volume and Issue:
17(1), P. 143 - 143
Published: Dec. 31, 2024
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
a
major
contributor
to
liver-related
morbidity,
cardiovascular
disease,
and
metabolic
complications.
Lifestyle
interventions,
including
diet
exercise,
are
first
line
in
treating
MASLD.
Dietary
approaches
such
as
the
low-glycemic-index
Mediterranean
diet,
ketogenic
intermittent
fasting,
high
fiber
diets
have
demonstrated
potential
addressing
dysfunction
underlying
this
condition.
The
development
progression
of
MASLD
closely
associated
with
taxonomic
shifts
gut
microbial
communities,
relationship
well-documented
literature.
Given
importance
primary
treatment
for
MASLD,
it
important
understand
how
microbiota
their
byproducts
mediate
favorable
outcomes
induced
by
healthy
dietary
patterns.
Conversely,
changes
conferred
unhealthy
patterns
Western
may
induce
dysbiosis
influence
through
promoting
hepatic
inflammation,
up-regulating
lipogenesis,
dysregulating
bile
acid
metabolism,
increasing
insulin
resistance,
causing
oxidative
damage
hepatocytes.
Although
emerging
evidence
has
identified
links
between
microbiota,
significant
gaps
remain
understanding
specific
roles,
metabolite
pathways,
host
interactions,
causal
relationships.
Therefore,
review
aims
provide
mechanistic
insights
into
role
microbiota-mediated
processes
analysis
both
contribution
pathophysiology.
By
better
elucidating
interplay
nutrients,
processes,
onset
work
identify
new
opportunities
targeted
interventions
treat
efficiently.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(9), P. 1564 - 1564
Published: May 1, 2025
Obesity
(OB)
has
become
a
serious
health
issue
owing
to
its
ever-increasing
prevalence
over
the
past
few
decades
due
contribution
severe
metabolic
and
inflammatory
disorders
such
as
cardiovascular
disease,
type
2
diabetes,
cancer.
The
unbalanced
energy
metabolism
in
OB
is
associated
with
substantial
epigenetic
changes
mediated
by
gut
microbiome
(GM)
structure
composition
alterations.
Remarkably,
experimental
evidence
also
indicates
that
OB-induced
modifications
adipocytes
can
lead
cellular
“memory”
alterations,
predisposing
individuals
weight
regain
after
caloric
restriction
subsequently
inducing
pathways
liver.
Various
environmental
factors,
especially
diet,
play
key
roles
progression
or
prevention
of
OB-related
modulating
GM
affecting
mechanisms.
Here,
we
will
first
focus
on
role
aberrations
development
OB.
Then,
discuss
association
between
abnormal
alterations
interplays
epigenome
Finally,
review
promising
strategies,
including
prebiotics,
probiotics,
methyl-rich
polyphenols,
herbal
foods
for
and/or
treatment
via
their
metabolites
influencing
epigenome.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: May 9, 2025
Rubus
chingii
Hu
(
R
.
)
is
a
valuable
edible
and
medicinal
plant.
It
contains
variety
of
surprising
active
compositions.
For
example,
polysaccharides,
phenols,
terpenes,
organic
acids,
benzenes,
flavonoids.
Among
them,
as
macromolecular
compounds,
are
receiving
increasing
attention
from
researchers.
Polysaccharides
obtained
have
anti-tumor,
anti-colitis,
immunomodulatory,
anti-obesity,
antioxidant
cytoprotective
effects.
In
this
paper,
the
extraction,
purification,
structural
characteristics
health
benefits
polysaccharides
were
reviewed,
which
laid
knowledge
foundation
provided
direction
for
future
research.
addition,
structure-activity
relationship
was
analyzed.
Its
actual
potential
applications
in
fields
food,
pharmaceuticals,
cosmetics
also
been
discussed.
This
provides
inspiration
research
development
its
products
functional
foods.
summary,
by
reviewing
on
recent
years,
it
will
help
researchers
deepen
their
understanding
them
facilitate
further
polysaccharides.
