Tissue Engineering and Spinal Cord Injury Repair DOI Creative Commons
Lai Xu, Songlin Zhou, Xiu Dai

et al.

Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Biodegradable conductive hydrogels generating magnetic-field-driven wireless electrical stimulation enhance the spinal cord injury repair DOI
Ping Wu, Ping Chen, Chao Xu

et al.

Nano Energy, Journal Year: 2024, Volume and Issue: 130, P. 110123 - 110123

Published: Aug. 15, 2024

Language: Английский

Citations

5
Frog‐Derived Neuroregenerative‐Peptide‐Reinforced Bioactive Hydrogels with Injectability, Thermosensitivity, and Enhanced Neurotrophic Function for Repairing Central Nervous Injuries DOI Creative Commons

Zhengang Sun,

Zhenjuan Sun,

Chenxi Du

et al.

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

The clinical treatment of central nervous system (CNS) injuries presents significant challenges due to the inflammatory microenvironment (IME) induced by CNS injury, which inhibits spontaneous neuronal regeneration. Biomimetic biomaterial‐based IMEs for repair, facilitate reconstruction neural regeneration circuits, show promise. In this study, development novel bioactive peptide nanofibers (PNFs)/chitosan (CS)/VD11 (VDELWPPWLPC) hydrogels (named as PCV) is reported, created reinforcing composite PNFs/CS with a frog‐derived neuroregenerative (VD11). exhibit 3D porous structure, high thermosensitivity, good injectability, and enhanced neurotrophic properties, making them promising candidates repair. in vitro tests indicate that PCV can promote proliferation, migration, differentiation stem cells into neurons, well guide axonal growth. Additionally, they help mitigate responses reducing macrophage activation astrocyte while promoting neovascularization. vivo animal experimentsdemonstrate enhance blood supply damaged area migration colonization endogenous support Furthermore, reduce immune limit excessive significantly improving motor function recovery rats spinal cord injuries. these findings, it suggested provide strategy treating regulating IME.

Language: Английский

Citations

0
Novel Tissue Engineering Scaffolds in the Treatment of Spinal Cord Injury—A Bibliometric Study DOI Creative Commons
Zhao Yan,

Abudunaibi Aili,

Zhiwei Jia

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 347 - 347

Published: March 28, 2025

Objective: Because of the evolving nature tissue engineering scaffolds in treatment spinal cord injury (SCI), current study was carried out to evaluate research productivity SCI. Methods: Studies published from 2000 2025 were retrieved Web Science core collection with topics and scaffolds. The data analyzed visualized using VOSviewer network analysis software. Results: Among 1542 articles analyzed, annual publications surged 2019, stabilizing thereafter. U.S., China, Canada led productivity, Northwestern University Biomaterials journal being top contributors. Keyword revealed hotspots such as functional recovery, axonal regeneration, stem cells, hydrogels. Notably, hydrogels embedded genetically engineered cells emerged a pivotal trend, reflecting shift toward biomimetic combinatorial therapies. Collaboration networks highlighted intensified partnerships between Chinese North American institutions, signaling global interdisciplinary efforts. Conclusions: This provides first bibliometric roadmap for SCI, identifying key trends, influential entities, underexplored areas. rise international collaborations underscores opportunities targeted research. These findings guide researchers prioritizing high-impact journals, fostering partnerships, advancing novel scaffold designs bridge translational gaps SCI treatment.

Language: Английский

Citations

0
Research Progress on Treating Spinal Cord Injury by Modulating the Phenotype of Microglia DOI Creative Commons

Qinghe Yu,

Ziming Cai, Xiaofeng Liu

et al.

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(9)

Published: Sept. 19, 2024

Spinal cord injury (SCI) is a severe central nervous system disorder with no currently available effective treatment. Microglia are immune cells in the that play crucial roles SCI occurrence, development, and recovery stages. They exhibit dynamic polarization over time can switch between classical activation (M1) alternative (M2) phenotypes to respond environmental stimuli. The M1 phenotype involved initiating sustaining inflammatory responses, while M2 exerts anti-inflammatory effects promotes tissue repair damaged areas. Inhibiting promoting have become hotspots regulating neuroinflammation treating SCI. This article provides comprehensive review centered on modulating microglial for

Language: Английский

Citations

2
Lycium barbarum oligosaccharide-derived carbon quantum dots inhibit glial scar formation while promoting neuronal differentiation of neural stem cells DOI

Fengxia Shao,

Xuan Sun, Qingtong Yu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137474 - 137474

Published: Nov. 9, 2024

Language: Английский

Citations

1
Silk-based biomaterials for promoting spinal cord regeneration: A review DOI

Jingjing Sun,

Min Ru, Mengjie Du

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 286, P. 138384 - 138384

Published: Dec. 6, 2024

Language: Английский

Citations

0
Tissue Engineering and Spinal Cord Injury Repair DOI Creative Commons
Lai Xu, Songlin Zhou, Xiu Dai

et al.

Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

0