Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106114 - 106114
Published: Aug. 31, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133744 - 133744
Published: July 8, 2024
Language: Английский
Citations
12
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141060 - 141060
Published: Feb. 1, 2025
Language: Английский
Citations
1
Colloids and Interface Science Communications, Journal Year: 2024, Volume and Issue: 61, P. 100793 - 100793
Published: July 1, 2024
This review provides a comprehensive overview of the advancements and potential applications calcium peroxide nanoparticles (CaO2 NPs) in combating bacterial infections. With rise antibiotic resistance posing significant global health threat, alternative antibacterial agents like CaO2 NPs have garnered increasing attention. The begins by discussing synthesis functionalization NPs, highlighting recent developments nanoparticle engineering techniques. Subsequently, it explores intricate mechanisms emphasizing their ability to generate reactive oxygen species disrupt biofilms. Evaluation NPs' efficacy against broad spectrum pathogens, coupled with discussions on various fields including biomedical environmental remediation, underscores promising role as effective agents. also addresses challenges such stability biocompatibility, proposes future research directions fully exploit therapeutic NPs. Overall, this consolidates current knowledge advocates for continued exploration
Language: Английский
Citations
5
Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 17, 2025
Malignant tumors pose a considerable threat to human life and health. Traditional treatments, such as radiotherapy chemotherapy, often lack specificity, leading collateral damage normal tissues. Tumor microenvironment (TME) is characterized by hypoxia, acidity, redox imbalances, elevated ATP levels factors that collectively promote tumor growth metastasis. This review provides comprehensive overview of the nanoparticles developed in recent years for TME-responsive strategies or TME-modulating methods therapy. The focus on designing synthesizing can interact with achieve precisely controlled drug release. These activate release under specific conditions within environment, thereby enhancing efficacy drugs while reducing toxicity cells. Moreover, simply eliminating cells does not fundamentally solve problem. Only comprehensively regulating TME make it unsuitable cell survival proliferation we more thorough therapeutic effects reduce risk recurrence. regulation aim suppress metastasis modulating various components TME. only improve treatment outcomes but also have potential lay foundation future personalized cancer therapies.
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1021 - 1046
Published: Jan. 1, 2025
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Oxaliplatin (OXA) currently primary chemotherapeutic agent for CRC, but its efficacy limited by tumor microenvironment (TME). Here, we present a combined approach chemotherapy and TME modulation CRC treatment. A multifunctional nanosystem (Rg3-Lip-OXA/CaO2) was established using Ginsenoside Rg3 liposomes targeting glucose transporter 1 overexpressed on surface cells to co-deliver OXA calcium peroxide (CaO2). The CaO2 nanoparticles were synthesized via CaCl2-H2O2 reaction under alkaline conditions characterized X-ray diffraction (XRD) photoelectron spectroscopy (XPS). Rg3-Lip-OXA/CaO2 prepared through thin-film hydration characterized; additionally, stability release behavior studied. O2, H2O2, Ca2+ generation ability in solution HCT116 measured. vitro cellular uptake observed fluorescence microscope flow cytometry. In cytotoxicity evaluated CCK-8 assay, cytometry, live/dead cell staining. vivo effect as well antitumor determined tumor-bearing mice. Finally, acute toxicity investigated ICR mice explore safety. XRD XPS analyses confirmed successful synthesis nanoparticles. exhibited an average particle size approximately 92.98 nm with good sustained behavior. studies optimal Rg3-Lip demonstrated that effectively produced H2O2 Ca2+, resulting significant cytotoxicity. Additionally, revealed substantial growth suppression reduced tumor-associated fibroblasts (TAFs) collagen. Acute indicated markedly drugs. This enhances reduces toxicity, offering promising optimizing treatment potential clinical application.
Language: Английский
Citations
0
Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 15, 2025
Photodynamic therapy (PDT) can induce tumor cell death. Ru3, a metal-based photosensitizer, features high positive charge, long triplet excited-state lifetime, and an excellent PDT activity. The aptamer AS1411, known for its ability to selectively bind nucleolin (which is overexpressed in cells), self-assembled with Ru3 into nanoparticles termed Ru3ApNPs. These specifically target SiHa cells. Upon light irradiation, Ru3ApNPs increase intracellular ROS levels, catalyze NADH redox reactions, lysosomal disruption, ultimately triggering pyroptosis Notably, demonstrate penetration 3D multicellular spheroids (MCSs) of cells effectively inhibit their growth under exposure. exhibit mechanism action distinct from that traditional PDT. Furthermore, the distant tumors systemic immune responses mice. Our data suggest be developed as promising targeted therapeutic agents future.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158081 - 158081
Published: Nov. 1, 2024
Language: Английский
Citations
3
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106114 - 106114
Published: Aug. 31, 2024
Language: Английский
Citations
0