Kiwifruit Polysaccharides Alleviate Ulcerative Colitis via Regulating Gut Microbiota-Dependent Tryptophan Metabolism and Promoting Colon Fucosylation DOI

Yixiao Li,

Yanhui Han, Xuejie Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(43), P. 23859 - 23874

Published: Oct. 21, 2024

A previous study showed that kiwifruit polysaccharide (KFP) has benefits in relieving intestinal inflammation, while the underlying mechanism remains unresolved. The objective of this was to investigate regulatory effect KFP on gut microbiota metabolism and barrier ulcerative colitis (UC) mice induced by dextran sulfate sodium (DSS). significantly improved UC symptoms including weight loss, shortened colon length, splenomegaly, diarrhea, hematochezia, inflammation mice. In addition, could alleviate DSS-caused dysbiosis increase levels short-chain fatty acids cecal contents Furthermore, results nontargeted targeted metabolomics analysis combined with antibiotic treatment revealed regulate microbiota-dependent tryptophan metabolism, activate aryl hydrocarbon receptor (AhR) cells, enhance interleukin-22 production tight junction proteins' (ZO-1, occludin, claudin3) expression repair Immunofluorescence upregulated conjunction lectin WGA UEA1 mouse colon, implying promoted fucosylation colon. These suggest alleviates primarily via targeting involved AhR pathway upregulating fucosylation.

Language: Английский

A galacturonic acid-rich polysaccharide from Citrus medica ‘fingered’ alleviated the dextran sulfate sodium-induced ulcerative colitis DOI
Feng Xiong, Hongyi Li, Hongliang Yao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 294, P. 139506 - 139506

Published: Jan. 5, 2025

Language: Английский

Citations

2
Potential of Dendrobium officinale oligosaccharides to alleviate chronic colitis by modulating inflammation and gut microbiota DOI
Dayu Shi, Peiyi Wang, Lei Xu

et al.

Food & medicine homology., Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

4
Hawthorn Pectin Alleviates DSS-Induced Colitis in Mice by Ameliorating Intestinal Barrier Function and Modulating Gut Microbiota DOI
Tao Li, Junbo Chen, Yuncong Xu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Pectin, as a kind of soluble dietary fiber in hawthorns, exhibits wide range biological activities. Nevertheless, its role and mechanism ulcerative colitis (UC) remain unclear. In this study, the effect hawthorn pectin (HP) against dextran sulfate sodium (DSS)-induced UC mice underlying were evaluated. HP dramatically alleviated pathological symptoms related to mice, displaying an increase body weight colon length inhibition damage. Importantly, inhibited serum levels inflammation-related factors including tumor necrosis factor-α, IL-1β, IL-6 well decreased number F4/80-positive macrophages colon. Moreover, expression ZO-1 occludin proteins intestinal permeability increased. A significant decrease dose-dependent manner at gut bacterial genus level (such Alistipes, Colidextribacter, Blautia) was observed after treatment. improved metabolic pathways microbiota increased concentrations short-chain fatty acids cecal contents mice. Intriguingly, fecal transplantation intervention with HP-derived microbiome notably relieved histopathological changes Conclusively, our study provided valuable insights into potential prebiotic for maintaining health confirmed that could ameliorate microbiota-dependent manner.

Language: Английский

Citations

0
Role of Mushroom Polysaccharides in Modulation of GI Homeostasis and Protection of GI Barrier DOI Creative Commons
Jianhui Liu, Yi Dai,

Wenjian Yang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Edible and medicinal mushroom polysaccharides (EMMPs) have been widely studied for their various biological activities. It has shown that EMMPs could modulate microbiota in the large intestine improve intestinal health. However, role of protecting gastric barrier, regulating microbiota, improving health cannot be ignored. Hence, this review will elucidate effect on barriers, with emphasis interaction maintaining overall gastrointestinal Additionally, highlights gastroprotective effects underlying mechanisms against mucosa injury, gastritis, ulcer, cancer. Furthermore, diseases, including inflammatory bowel disease, colorectal cancer, infection, are also summarized. This discuss future perspective challenges use as a dietary supplement or nutraceutical preventing treating diseases.

Language: Английский

Citations

0
Effects of Ficus carica L. polysaccharide on the intestinal immune function and microbiota of broilers DOI Creative Commons
Yabin Lü,

Sajidaimu Maimaiti,

Zhendong Qin

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

Ficus carica L. polysaccharides (FLPs) are groups of biologically active compounds extracted from In this study, we analyzed the structure FLPs, predicted their immune enhancement pathway, and detected impact FLPs on growth performance, function, intestinal microflora broiler chickens. The results showed that comprised monosaccharides including rhamnose, arabinose, mannose, glucose, galactose. Feeding with significantly promoted slaughtering organs index chickens compared to control group (p < 0.05). Moreover, FLP-h FLP-m had increased levels sIgA, IgG, IL-4, IL-5, IL-12, IFN-g; improved immunity barrier function; a higher percentage spleen CD4+ CD8+ T cell differentiation Additionally, various SCFAs, beneficial bacteria such as Firmicutes at phylum level Faecalibacterium, Blautia, Phascolarctobacterium, Alistipes genus level. network pharmacology KEGG pathway prediction indicate may change metabolism microbiota by enhancing carbon fixation pathways in prokaryotes, promote function through joint action bisphenol degradation, retinol metabolism, NODlike signaling pathways, toll-like receptor MAPK pathway. These suggest supplementation effectively promotes performance enhances mucosal

Language: Английский

Citations

0
Unraveling the protective mechanisms and bioactive components of litchi polysaccharides in intestinal health DOI
Danmeng Luo,

Ruina Xu,

Jiang Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143383 - 143383

Published: April 1, 2025

Language: Английский

Citations

0
Pectin from comfrey roots alleviate DSS-induced ulcerative colitis in mice through modulating the intestinal barrier DOI
Mengxue Liu, Jia Fu, Yuqian Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137016 - 137016

Published: Oct. 1, 2024

Language: Английский

Citations

3
Structure Characterization and Treatment Effect of Zingiber officinale Polysaccharide on Dextran Sulfate Sodium-Induced Ulcerative Colitis DOI Creative Commons
Yongshuai Jing,

Ziying Wang,

Wenjing Cheng

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 753 - 753

Published: Feb. 23, 2025

Ulcerative colitis (UC) is on the rise all over world. Zingiber officinale polysaccharide (ZOP-1) has good anti-inflammatory and antioxidant effects, but therapeutic effect mechanism of ZOP-1 UC are still unclear. obtained by water extraction alcohol precipitation was analyzed methylation NMR. At same time, in treatment clarified hematoxylin-eosin (HE) staining, metagenomics, immunohistochemistry, protein blot (Wb). structure →4,6)-β-Glcp-1→ →3,6)-α-Galp-(1→ constitute main chain, there were two branched chain →4)-β-Glcp(1→, α-Araf(1→ as end group. significantly improved shortening thickening colon, changed index immune organs, inhibited production inflammatory factors mice with ulcerative colitis, intestinal flora mice, increased content short-chain fatty acids (SCFAs) intestine, controlled TLR4/NF-κB/MAPK signaling pathway, thus preventing treating DSS-induced mice. alleviated controlling expression cytokines, thereby reducing inflammation oxidative stress, enhancing integrity, modulating flora, regulating levels SCFAs.

Language: Английский

Citations

0
Kiwifruit Polysaccharides Alleviate Ulcerative Colitis via Regulating Gut Microbiota-Dependent Tryptophan Metabolism and Promoting Colon Fucosylation DOI

Yixiao Li,

Yanhui Han, Xuejie Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(43), P. 23859 - 23874

Published: Oct. 21, 2024

A previous study showed that kiwifruit polysaccharide (KFP) has benefits in relieving intestinal inflammation, while the underlying mechanism remains unresolved. The objective of this was to investigate regulatory effect KFP on gut microbiota metabolism and barrier ulcerative colitis (UC) mice induced by dextran sulfate sodium (DSS). significantly improved UC symptoms including weight loss, shortened colon length, splenomegaly, diarrhea, hematochezia, inflammation mice. In addition, could alleviate DSS-caused dysbiosis increase levels short-chain fatty acids cecal contents Furthermore, results nontargeted targeted metabolomics analysis combined with antibiotic treatment revealed regulate microbiota-dependent tryptophan metabolism, activate aryl hydrocarbon receptor (AhR) cells, enhance interleukin-22 production tight junction proteins' (ZO-1, occludin, claudin3) expression repair Immunofluorescence upregulated conjunction lectin WGA UEA1 mouse colon, implying promoted fucosylation colon. These suggest alleviates primarily via targeting involved AhR pathway upregulating fucosylation.

Language: Английский

Citations

2