Progress and opportunities in gellan gum and collagen as wound healing materials: A review DOI Creative Commons

Aznatul Jannah binti Abu Bakar,

Khairul Anuar Mat Amin

Science, Engineering and Health Studies, Journal Year: 2024, Volume and Issue: unknown, P. 24010004 - 24010004

Published: Dec. 31, 2024

Gellan gum and collagen are two biomaterials that have been extensively studied for their potential use in wound healing tissue engineering applications. is a biologically inert natural polymer increasingly favored as biomaterial to form hydrogels. Collagen, on the other hand, major component of extracellular matrix widely used applications due its biocompatibility ability promote cell adhesion proliferation. In this review, recent research will be discussed related gellan collagen, properties, engineering.

Language: Английский

Adhesive transparent antimicrobial quaternized chitosan/oxidized dextran/polydopamine nanoparticle hydrogels for accelerated wound healing DOI

Pu Hou,

Kun Lei,

Zhishen Zhang

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 169, P. 214176 - 214176

Published: Jan. 9, 2025

Language: Английский

Citations

1
Antibacterial polyurethane foams with quaternized-chitosan as a chain extender for nasal packing and hemostasis DOI
Kaidi Ding,

Wenlong Cong,

Ying Liu

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 181, P. 249 - 262

Published: May 3, 2024

Language: Английский

Citations

7
Constructing a hierarchical composite scaffold with a honeycomb-like micro-network for bone regeneration using a one-step freeze-casting strategy DOI

Yang Xiaomin,

Qiwei Shi, Shuting Wang

et al.

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
A Safe, Stable, Simple, Serviceable, and Self‐Powered Wound Dressing With Continuous Low‐Voltage Direct Current Electrical Stimulation: an Efficient Approach to Accelerate Wound Healing DOI Open Access

Chenxi Shi,

Huan Wang, Xiaojing Wang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Electrical stimulation (ES) dressings have garnered considerable attention owing to their profound impact on chronic wound care, while the existing ES necessitate external power supply or intricate structures, posing potential safety risks and usage inconveniences. Herein, a safe, stable, simple, serviceable, self‐powered (5S) dressing composed of an electrospinning asymmetric nanofiber membrane with screen‐printed electrodes polyurethane foam is developed. The acts as due its electrical double‐layer effect during unidirectional exudate transfer, excellent water absorption retention properties effectively manages exudate. This 5S generates sustained low‐voltage direct current in situ at site creates favorable microenvironment for re‐epithelization. In vitro vivo studies indicate that this can significantly promote healing. Compared control group (on 7th day), collagen deposition treated increased by 15.9%, capillary density 90.6%, epidermal thickness 228.3%, resulting 23.6% enhancement healing rate. Consequently, presents highly sophisticated effective therapeutic approach accelerating

Language: Английский

Citations

0
Multifunctional Chitosan/Cellulose/Tannic Acid Biocomposite Sponge with Excellent Biocompatibility for Rapid Hemostasis DOI

Yuanyuan Ma,

Guowei Da,

Lei He

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Hemostatic materials should have efficient and rapid hemostasis, good biocompatibility, nontoxicity. However, common hemostatic sponges often fail due to their weak mechanical strength, low slow hemostasis. Herein, we developed novel multifunctional chitosan/cellulose/tannic acid (CS/OMCC/TA) biocomposite by a freeze-drying method without adding any chemical cross-linking agents. The water absorption rate of the sponge is as high 4404%, blood 5460%. In vitro coagulation tests shown that ability CS/OMCC/TA significantly better than commercial hemostasis materials. DPPH radical scavenging test antibacterial experiments demonstrated excellent antioxidant properties inhibitory effects on Staphylococcus aureus Escherichia coli. Animal showed could rapidly hemostasize within 185 s loss was 107 mg. These findings provide biocompatible for daily emergency trauma treatment surgical

Language: Английский

Citations

0
Chitosan and its derivatives as potential biomaterials for biomedical and pharmaceutical applications: A comprehensive review on green extraction approaches, recent progresses, and perspectives DOI
M. Hamdi, Heng Sun, Lixia Pan

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113882 - 113882

Published: March 1, 2025

Language: Английский

Citations

0
Poly(vinyl alcohol)/Polycaprolactone Nanofiber Enriched with Lichenysin against Multidrug-Resistance Bacterial Infection in Wound Healing: In Vitro Studies and In Vivo Evaluation in Wistar Rats DOI
Swati Yadav, Dilip Kumar Arya, Shubham Kanaujiya

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Multidrug resistance (MDR) infectious wounds are a major concern due to drug resistance, leading increased patient morbidity. Lichenysin (LCN), lipopeptide and biosurfactant obtained from certain strains of Bacillus licheniformis, has demonstrated an excellent antimicrobial property. The present study focuses on the fabrication comprehensive evaluation LCN-incorporated poly(vinyl alcohol) (PVA)/polycaprolactone (PCL)-based nanofiber scaffolds using electrospinning technique as potential wound healing biomaterial for treatment MDR in diabetic rats. LCN-loaded PVA–PCL were characterized their physicochemical, antimicrobial, vitro cell line L-929, hemocompatibility, flow cytometry, vivo healing, enzyme-linked immuno sorbent assay (ELISA). Morphological analysis via scanning electron microscopy (SEM) images confirmed smooth porous nanofibers with diameters range 200–300 nm. Fourier transform infrared X-ray diffraction (XRD) results structural integrity, chemical compatibility, amorphous nature developed scaffolds. loaded LCN water retention, moderate biodegradability, sustained release up 72 h. Mechanical characterization robust tensile strength conducive applications. Antimicrobial activity against Pseudomonas aeruginosa (P. aeruginosa) Staphylococcus aureus (S. aureus) showed substantial antibacterial antibiofilm activity. In studies enhanced adhesion, proliferation, migration, viability, signifying cytocompatibility these exceptional These findings indicate that LCN-enriched hold significant therapeutic strategy rats through multifaceted approach.

Language: Английский

Citations

0
An NIR-Responsive “4A hydrogel” Encapsulating Wormwood Essential Oil: through Antibacterial, Antioxidant, Anti-inflammation, and Angiogenic to Promote Diabetic Wound Healing DOI Creative Commons

Mengjuan Tao,

Zhiwei Sun,

Haiyan Wang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101751 - 101751

Published: April 1, 2025

Language: Английский

Citations

0
Preparation and characterization of advancing wound care with PVP/QCS/DEX hydrogels: a multifunctional wound dressing composite: in vitro and in vivo assay DOI

Moosa Hatami,

Mohammad Taghi Khorasani, Ebrahim Ahmadi

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: April 17, 2025

Although the skin has a high healing capacity, severe wounds often require external interventions to heal properly. Tissue-engineered wound dressings have indeed gained significant attention among various treatment strategies for healing. This study focuses on integration of polyvinyl pyrrolidone (PVP), quaternized chitosan (QCS), and dextran (DEX) prepare ternary composite (PVP/QCS/DEX) as dressing hydrogels with varying concentration PVP DEX. A variety analytical methods, including infrared spectroscopy (FTIR), scanning electron microscopy (SEM), contact angle, water vapor transmission rate (WVTR) were employed assess characteristics samples. The uniform interconnected porous structure samples was confirmed by SEM results. All showed porosity transition rate, demonstrating their ability provide suitable moist environment efficient exudate handling antibacterial test conducted demonstrated activity drug-loaded hydrogel Escherichia coli Staphylococcus aureus. in vitro cytotoxicity evaluation using MTT assay that developed PVP/QCS/DEX exhibit satisfactory cytocompatibility promote cell viability. results scratch indicated had promoted migration would improve accelerate process. vivo tests sample revealed promising performance. Therefore, based favorable performance observed throughout analysis, as-prepared show promise field dressings.

Language: Английский

Citations

0
Development and characterization of three-dimensional antibacterial nanocomposite sponges of chitosan, silver nanoparticles and halloysite nanotubes DOI Creative Commons
A. Hernández‐Rangel, Phaedra Silva-Bermúdez, Argelia Almaguer‐Flores

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(34), P. 24910 - 24927

Published: Jan. 1, 2024

We have developed novel three-dimensional scaffolds composed of chitosan, halloysite nanotubes and silver nanoparticles with enhanced antimicrobial activity fibroblast cell compatibility for their potential use in wound dressing applications.

Language: Английский

Citations

2