Reprogrammed Lung Metastasis Immunodeficiency via Targeted Penetrated Delivery of M1 Macrophage‐Wrapped NanoCubes‐Mediated T Cell Infiltration DOI Open Access
Kangli Wang,

Cheng‐Han Li,

Pin‐Xuan Huang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

The infiltration of cytotoxic T lymphocytes holds promise for suppressing even the most resilient metastatic tumors in immunotherapy. Polarizing tumor-associated macrophages (TAMs) and remodeling immune-deficient tumor microenvironment (TME) can enhance lymphocyte recruitment infiltration. However, immune privilege low immunogenic responses these aggressive clusters often limit recruitment. Here, an M1 macrophage membrane-coated iron oxide nanoparticle (IO@MM) double as a tumor-penetrated agent naïve M0 to polarizer is developed lung colorectal cancer (CRC) At site, IO@MM combined with resiquimod (R848) increased cell infiltration, turning "Cold" TME into immune-activating "Hot" one. Together self-cascade immunotherapy, R848 promotes release damage-associated molecular patterns (DAMPs). same time, uses membrane antigen reservoir provides autologous DAMPs retain dendritic cells. This effectively inhibits improves survival rate immunomodulator metastasis.

Language: Английский

A Self-Cascade Penetrating Brain Tumor Immunotherapy Mediated by Near-Infrared II Cell Membrane-Disrupting Nanoflakes via Detained Dendritic Cells DOI Creative Commons

Bhanu Nirosha Yalamandala,

Yu-Jen Chen,

Ya‐Hui Lin

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(28), P. 18712 - 18728

Published: July 2, 2024

Immunotherapy can potentially suppress the highly aggressive glioblastoma (GBM) by promoting T lymphocyte infiltration. Nevertheless, immune privilege phenomenon, coupled with generally low immunogenicity of vaccines, frequently hampers presence lymphocytes within brain tumors, particularly in tumors. In this study, membrane-disrupted polymer-wrapped CuS nanoflakes that penetrate delivery to deep tumors via releasing cell-cell interactions, facilitating near-infrared II (NIR II) photothermal therapy, and detaining dendritic cells for a self-cascading immunotherapy are developed. By convection-enhanced delivery, amphiphilic polymer micelles (poly(methoxypoly(ethylene glycol)-benzoic imine-octadecane, mPEG-b-C18) enhances tumor permeability resides Under low-power NIR irradiation (0.8 W/cm2), intense heat generated well-distributed actuates thermolytic efficacy, cell apoptosis subsequent antigen release. Then, positively charged after hydrolysis benzoic-imine bond serves as an depot, autologous tumor-associated antigens presenting them cells, ensuring sustained stimulation. This penetrative amplifies response postoperative but also survival outcomes through effective immunotherapy.

Language: Английский

Citations

13
Reprogramming Dysfunctional Dendritic Cells by a Versatile Catalytic Dual Oxide Antigen-Captured Nanosponge for Remotely Enhancing Lung Metastasis Immunotherapy DOI Creative Commons

Min‐Ren Chiang,

Chin-Wei Hsu,

Wulin Pan

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Dendritic cells (DCs) play a crucial role in initiating antitumor immune responses. However, the tumor environment, dendritic often exhibit impaired antigen presentation and adopt an immunosuppressive phenotype, which hinders their function reduces ability to efficiently present antigens. Here, dual catalytic oxide nanosponge (DON) doubling as remotely boosted catalyst inducer of programming DCs program therapy is reported. Intravenous delivery DON enhances accumulation via marginated target. At site, incorporates cerium nanozyme (CeO

Language: Английский

Citations

6
The dual role of photodynamic therapy to treat cancer and microbial infection DOI

Farheen Akhtar,

Lama Misba,

Asad U. Khan

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(8), P. 104099 - 104099

Published: July 11, 2024

Language: Английский

Citations

4
Tumor-targeted delivery of hyaluronic acid/polydopamine-coated Fe2+-doped nano-scaled metal–organic frameworks with doxorubicin payload for glutathione depletion-amplified chemodynamic-chemo cancer therapy DOI

Kai-An Liang,

Hsiang-Yun Chih,

I-Ju Liu

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 677, P. 400 - 415

Published: July 31, 2024

Language: Английский

Citations

4
Photothermal-enhanced ROS storm by hyaluronic acid-conjugated nanocatalysts to amplify tumor-specific photo-chemodynamic therapy and immune response DOI
T. Lin,

I-Ju Liu,

Hsiang-Yun Chih

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142975 - 142975

Published: April 1, 2025

Language: Английский

Citations

0
Enhanced Intracellular IR780 Delivery by Acidity-Triggered PEG-Detachable Hybrid Nanoparticles to Augment Photodynamic and Photothermal Combination Therapy for Melanoma Treatment DOI Creative Commons

Min‐Chen Tsai,

L. T. Hsiao,

Yen-Hsuan Chang

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

The PEGylation of drug-carrying nanoparticles has often been used to prolong blood circulation and improve drug deposition at tumor sites. Nevertheless, the PEG-rich hydrophilic surfaces retard release payloads internalization therapeutic by cancer cells, thus lowering anticancer efficacy. To boost potency combined photodynamic therapy (PDT) photothermal (PTT) against melanoma conquering PEG dilemma, herein, hybrid PEGylated chitosan-covered polydopamine (PDA) (PCPNs) with acidity-elicited detachment ability were fabricated as carriers IR780, a small-molecule photosensitizer for PTT PDT. IR780@PCPNs displayed uniform, solid-like spherical shape sound colloidal stability. Under near-infrared (NIR) irradiation, showed prominent conversion efficiency (ca. 54.6%), robust stability, reduced IR780 photobleaching, sufficient singlet oxygen (1O2) production, glutathione-depleting ability. Moreover, environmental pH being from 7.4 5.0 37 °C, decreased interactions between PCPNs due increased protonation phenolic hydroxyl residues within PDA primary amine groups chitosan accelerated species IR780@PCPNs. Importantly, cellular uptake B16F10 was remarkably promoted in weakly acidic milieu upon driven disintegration acid-labile benzoic imine. With NIR internalized generated hyperthermia 1O2 damage mitochondria, thereby effectively inhibiting proliferation cells. Collectively, our findings present practical strategy amplifying efficacy PDT using PEG-detachable

Language: Английский

Citations

0
Advances in Chitosan Derivatives: Preparation, Properties and Applications in Pharmacy and Medicine DOI Creative Commons
Dominika Žigrayová, Veronika Mikušová, Peter Mikuš

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 701 - 701

Published: Oct. 29, 2024

Chitosan (CS) derivatives have been extensively investigated to enhance the physicochemical and biological properties of CS, such as its solubility, biocompatibility, bioactivity, which are required in various areas pharmacy medicine. The present work emphasizes ongoing research development this field, suggesting that further exploration CS could lead innovative solutions benefit society. properties, activities, methods preparation, advantages, limitations, intended application areas, realized practical implementations particular summarized discussed herein. Despite numerous promising attributes reported paper, however, challenges like target selectivity, standardization (purity, chitosan structural variability), cost-effectiveness still need addressing for widespread implementation, especially drug delivery. Therefore, basic studies prevail delivery systems. However, specific applications wound healing tissue engineering, practice found be more frequent. To obtain a complex view topic, information from scientific papers reviewed is supplemented with actual patents clinical studies. Both advances most successful important medical concerning future perspectives.

Language: Английский

Citations

3
NIR-intervened thermally accelerated urease-propelled MOF nanosubmarine for antibiotic-free antibacterial inhibition via single-wavelength synergistic PDT/PTT DOI
L. Zhang, Yu Liu, Shupeng Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137367 - 137367

Published: Nov. 6, 2024

Language: Английский

Citations

1
Reprogrammed Lung Metastasis Immunodeficiency via Targeted Penetrated Delivery of M1 Macrophage‐Wrapped NanoCubes‐Mediated T Cell Infiltration DOI Open Access
Kangli Wang,

Cheng‐Han Li,

Pin‐Xuan Huang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

The infiltration of cytotoxic T lymphocytes holds promise for suppressing even the most resilient metastatic tumors in immunotherapy. Polarizing tumor-associated macrophages (TAMs) and remodeling immune-deficient tumor microenvironment (TME) can enhance lymphocyte recruitment infiltration. However, immune privilege low immunogenic responses these aggressive clusters often limit recruitment. Here, an M1 macrophage membrane-coated iron oxide nanoparticle (IO@MM) double as a tumor-penetrated agent naïve M0 to polarizer is developed lung colorectal cancer (CRC) At site, IO@MM combined with resiquimod (R848) increased cell infiltration, turning "Cold" TME into immune-activating "Hot" one. Together self-cascade immunotherapy, R848 promotes release damage-associated molecular patterns (DAMPs). same time, uses membrane antigen reservoir provides autologous DAMPs retain dendritic cells. This effectively inhibits improves survival rate immunomodulator metastasis.

Language: Английский

Citations

1