Cavity Lasing of Thioflavin T in the Condensed Phase for Discrimination between Surface Interaction and β-Sheet Groove Binding in Alzheimer-Linked Peptides DOI Creative Commons
P Hańczyc

The Journal of Physical Chemistry Letters, Journal Year: 2024, Volume and Issue: unknown, P. 9543 - 9547

Published: Sept. 12, 2024

This study investigates the lasing effects in a Fabry-Perot cavity to discern binding interactions of thioflavin T (ThT) with various peptides associated Alzheimer's disease, including Aβ(1-42), KLVFFA, and diphenylalanine (FF) condensed phase. Utilizing kinetic measurements, research explores ThT emission enhancements due specific groove β-sheet structures highlights additional contributions from weak surface solvent-solute interactions. Lasing spectroscopy reveals lack transition FF system its native state an amyloid-like structure, challenging traditional assay interpretations. These findings show potential elucidating molecular basis amyloid fibril formation development diagnostic tools for amyloidogenic diseases.

Language: Английский

Thioflavin T: induced circular dichroism and density functional theory as promising approach in amyloid fibril assays DOI
Aurica Precupaş, Iulia Matei

Applied Spectroscopy Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 39

Published: May 11, 2025

Language: Английский

Citations

0
Cavity Lasing of Thioflavin T in the Condensed Phase for Discrimination between Surface Interaction and β-Sheet Groove Binding in Alzheimer-Linked Peptides DOI Creative Commons
P Hańczyc

The Journal of Physical Chemistry Letters, Journal Year: 2024, Volume and Issue: unknown, P. 9543 - 9547

Published: Sept. 12, 2024

This study investigates the lasing effects in a Fabry-Perot cavity to discern binding interactions of thioflavin T (ThT) with various peptides associated Alzheimer's disease, including Aβ(1-42), KLVFFA, and diphenylalanine (FF) condensed phase. Utilizing kinetic measurements, research explores ThT emission enhancements due specific groove β-sheet structures highlights additional contributions from weak surface solvent-solute interactions. Lasing spectroscopy reveals lack transition FF system its native state an amyloid-like structure, challenging traditional assay interpretations. These findings show potential elucidating molecular basis amyloid fibril formation development diagnostic tools for amyloidogenic diseases.

Language: Английский

Citations

1