Multifunctional Polyoxovanadate-Based Covalent Organic Polymer for Bacteria-Infected Wound Therapy DOI
Yinuo Li, Liyan Zhao,

Manli Liu

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

The special pathological microenvironment of infected wounds (pathology weakly acidic, hypoxic, and overexpressed H2O2) provides fertile soil for the development disease. Tailoring treatment based on specific characteristics infectious (IME) has emerged as a novel direction in antimicrobial therapies. Here, polyoxovanadate (POV)-based covalent organic polymer (POV-Fc-COP) with inherent photothermal activity was facilely prepared via copolymerization 1,1′-bi(3-dimethylamino-1-oxo-2-enyl-ferrocene) (BDOEF) tris-NH2-modified POV (tris-V6O9), which nanovanadium oxide (V2O3 V2O5) core shell were generated directly during Michael addition–elimination reaction. unique structure composition impart pH-responsive peroxidase-like (POD-like) catalase-like (CAT-like) activities, concurrently, to POV-Fc-COP. Specifically, acid-activated mimicking-POD could consume H2O2 microenvironment, producing toxic •OH combat bacteria biofilms. vanadium consumes excessive acid, resulting an increase pH. Meanwhile, CAT-like transform excess expression into O2 relieve hypoxia induced by damage blood vessels facilitate wound healing. Additionally, synergistic amplified therapeutic effect triggered application laser irradiation facilitates rapid eradication biofilm, minimizing detrimental impacts bacterial proliferation IME, thereby accelerating restoration IME return normal state. Therefore, POV-Fc-COP dual-enzyme functionality not only utilize but also regulate significantly expediting healing bacteria-infected wounds. This study demonstrates simple method preparation intelligent platform programmed antibacterial antibiofilm formation, thus promoting while utilizing improving IME.

Language: Английский

Modulating Polyphenol Activity with Metal Ions: Insights into Dermatological Applications DOI Creative Commons
Oana Cioancă, Ionuţ-Iulian Lungu, Denisa Batîr-Marin

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 194 - 194

Published: Feb. 4, 2025

Background: The skin represents the first barrier of defense, and its integrity is crucial for overall health. Skin wounds present a considerable risk seeing how their progression rapid sometimes they are caused by comorbidities like diabetes venous diseases. Nutraceutical combinations ones between polyphenols metal ions applications thanks to increased bioavailability ability modulate intrinsic molecular pathways. Methods: research findings presented in this paper based on systematic review current literature with an emphasis nanotechnology regenerative medicine strategies that incorporate metallic nanoparticles (NPs). key studies which described action mechanisms, efficacy, safety these hybrid formulations were reviewed. Results: Nanocomposites polyphenol promote healing activating signaling pathways such as PI3K/Akt ERK1/2, turn improve fibroblast migration proliferation. Nanoparticles silver copper have antibacterial, angiogenesis-promoting, inflammation-modulating capabilities. With induce apoptosis restrict cell growth, composites potential cure malignancies addition facilitating wound healing. Conclusions: metals provide hope treatment cancer chronic wounds. Their antimicrobial capabilities, capacity inflammatory responses, enhancement activity all point medicinal potential. Furthermore, decrease inflammation associated tumors while simultaneously inducing death cells. Clarifying guaranteeing stability, enhancing effective delivery techniques clinical usage should be focus future studies.

Language: Английский

Citations

0
Enhancement of solar water evaporation in copper-sodium humate/SA/PAM hydrogels via an environmental heat field DOI

Bingxue Huang,

Jie Liu,

Jia Xie

et al.

Separation and Purification Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132784 - 132784

Published: March 1, 2025

Language: Английский

Citations

0
Review of Metal–Polyphenol Self-Assembled Nanoparticles: Synthesis, Properties, and Biological Applications in Inflammatory Diseases DOI
Huiying Li, Shuang Li, Jiawei Du

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Polyphenols, which are compounds characterized by the presence of phenolic hydroxyl groups, abundantly found in natural plants and exist highly complex forms within living organisms. As some most prevalent nature, polyphenols possess significant medicinal value due to their unique structural features, particularly therapeutic efficacy antitumor, anti-inflammatory, antibacterial applications. In context inflammation therapy, polyphenolic can inhibit excessive release inflammatory mediators from cells, thereby mitigating inflammation. Furthermore, these exhibit strong antioxidant properties, enabling them scavenge free radicals reactive oxygen species (ROS), reduce oxidative stress-related damage, exert anti-inflammatory effects. Due multiple groups ability chelate various metals, extensively utilized synthesis self-assembled nanoparticles for treatment diseases. Numerous studies have demonstrated that profile formed through self-assembly with metal ions surpasses alone. This Review will focus on different generate nanoparticles, characterization, applications inflammation-related diseases, providing researchers new insights into synthetic study metal-polyphenol nanocomposites biological

Language: Английский

Citations

0
Application of green waste polyphenols in natural antimicrobial materials for the environmental fields: A review DOI
Yuqian Zhou, Zhongxin Tan

Waste Management, Journal Year: 2025, Volume and Issue: 202, P. 114800 - 114800

Published: April 27, 2025

Language: Английский

Citations

0
Advances in nanozymes with peroxidase-like activity for biosensing and disease therapy applications DOI

Xiaohua Yuan,

Xun He, Jiwen Fan

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

This review explores the different types of nanozymes with POD-like activity and discusses their regulation, particularly emphasizing latest development trends advances in biosensing disease treatment.

Language: Английский

Citations

2
A pH-sensitive, renewable invisible orthodontic aligners coating manipulates antibacterial and in situ remineralization functions to combat enamel demineralization DOI Creative Commons

Qi Qin,

Wenhong Yuan,

Jiarui Zhang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: July 22, 2024

During invisalign treatment, as salivary proteins or glycoproteins fill the space between teeth and aligners, they can easily adhere to teeth, forming an acquired cellular film on which bacteria are highly susceptible colonizing, in turn leads development of enamel white staining lesions (WSLs), one major complications orthodontic treatment. Inhibiting activity cariogenic while promoting remineralization demineralized is key preventing treating WSLs. Currently, drug commonly used clinical practice for treatment WSLs silver diamine fluoride, which, although it has both antimicrobial remineralizing effects, suffers from problems such pulpal irritation tooth discoloration. In this study, based principle coordination chemistry, copper ions plant polyphenol tannins were assembled invisible aligners form a metal–phenol network coating (TA-Cu MPNs), zwitterionic sulfonamethyldopamine was introduced bionic mineralization obtain multifunctional TA-Cu MPNs@ZDS@CaP (TZC). The exhibits acid-responsive release Ca 2+ PO 4 3− , decomposed CaP layer be regenerated by simple dipping method. TZC strongly inhibits common their biofilms. addition, results vitro experiment show that TZC-coated aligner significant effects. It worth mentioning constructed durable antibacterial effect meet service cycle aligners. This study provides theoretical experimental bases prevention

Language: Английский

Citations

1
In Vitro and In Vivo Biological Evaluation of Novel 1,4‐Naphthoquinone Derivatives as Potential Anticancer Agents DOI
Palanisamy Ravichandiran, Aleksandra Martyna, Elżbieta Kochanowicz

et al.

ChemMedChem, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

Abstract A novel library of naphthoquinone derivatives ( 3–5 aa ) was synthesized and evaluated for their anticancer properties. Specifically, compounds 5 i, l, o, q, r, s, t , v demonstrated superior cytotoxic activity against the cancer cell lines that were studied. All studied exhibited a higher selectivity index (SI) favourable safety profile than standard drug doxorubicin. Notably, compound displayed greater effect on MCF‐7 cells (IC 50 =1.2 μM, 0.9 μM at 24 h 48 h, respectively) compared to doxorubicin =2.4 2.1 respectively). To further investigate mechanism effect, additional studies conducted with in cells. The are including morphological changes, AO/EB (acridine orange/ethidium bromide) double staining, apoptosis analysis, colony assay, SDS‐PAGE Western blotting, cycle detecting reactive oxygen species (ROS) assay. findings showed triggered effects through initiation arrest G1/S phase necrosis. In vivo ecotoxicity indicated had lower toxicity towards zebrafish larvae (LC =50.15 μM) an insignificant impact cardiac functions. xenotransplantation significant reduction tumour volume xenograft. Approximately 95 % xenografts survived after 10 days treatment. Finally, computational modelling study four protein receptors, namely ER, EFGR, BRCA1, VEFGR2. highlight importance aminonaphthoquinone moiety, amide linkage, propyl thio moiety enhancing drug‐likeness features docking scores (−9.1, −7.1, −8.9, −10.9 kcal/mol) (−7.2, −6.1, −6.9, −7.3 VEGFR2 respectively. Therefore, notable antitumor suggest these molecular frameworks may play role development promising agents

Language: Английский

Citations

1
Tailored design of polyamide nanofiltration membrane interlayer via dynamic-polyphenol polymerization for complex inorganic salts separation DOI
Ruixian Zhang, Wenjie Chen,

Yanfei Gao

et al.

Journal of Membrane Science, Journal Year: 2024, Volume and Issue: 712, P. 123243 - 123243

Published: Aug. 24, 2024

Language: Английский

Citations

0
Multifunctional Polyoxovanadate-Based Covalent Organic Polymer for Bacteria-Infected Wound Therapy DOI
Yinuo Li, Liyan Zhao,

Manli Liu

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

The special pathological microenvironment of infected wounds (pathology weakly acidic, hypoxic, and overexpressed H2O2) provides fertile soil for the development disease. Tailoring treatment based on specific characteristics infectious (IME) has emerged as a novel direction in antimicrobial therapies. Here, polyoxovanadate (POV)-based covalent organic polymer (POV-Fc-COP) with inherent photothermal activity was facilely prepared via copolymerization 1,1′-bi(3-dimethylamino-1-oxo-2-enyl-ferrocene) (BDOEF) tris-NH2-modified POV (tris-V6O9), which nanovanadium oxide (V2O3 V2O5) core shell were generated directly during Michael addition–elimination reaction. unique structure composition impart pH-responsive peroxidase-like (POD-like) catalase-like (CAT-like) activities, concurrently, to POV-Fc-COP. Specifically, acid-activated mimicking-POD could consume H2O2 microenvironment, producing toxic •OH combat bacteria biofilms. vanadium consumes excessive acid, resulting an increase pH. Meanwhile, CAT-like transform excess expression into O2 relieve hypoxia induced by damage blood vessels facilitate wound healing. Additionally, synergistic amplified therapeutic effect triggered application laser irradiation facilitates rapid eradication biofilm, minimizing detrimental impacts bacterial proliferation IME, thereby accelerating restoration IME return normal state. Therefore, POV-Fc-COP dual-enzyme functionality not only utilize but also regulate significantly expediting healing bacteria-infected wounds. This study demonstrates simple method preparation intelligent platform programmed antibacterial antibiofilm formation, thus promoting while utilizing improving IME.

Language: Английский

Citations

0