Copper(II) Oxide Spindle-like Nanomotors Decorated with Calcium Peroxide Nanoshell as a New Nanozyme with Photothermal and Chemodynamic Functions Providing ROS Self-Amplification, Glutathione Depletion, and Cu(I)/Cu(II) Recycling DOI Creative Commons

Çağıl Zeynep Süngü Akdoğan,

Esin Akbay, Mehmet Ali Onur

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Uniform, mesoporous copper(II) oxide nanospindles (CuO NSs) were synthesized via a method based on templated hydrothermal oxidation of copper in the presence monodisperse poly(glycerol dimethacrylate-co-methacrylic acid) nanoparticles (poly(GDMA-co-MAA) NPs). Subsequent decoration CuO NSs with CaO2 nanoshell (CuO@CaO2 yielded nanozyme capable Cu(I)/Cu(II) redox cycling. Activation cycle by exogenously generated H2O2 from significantly enhanced glutathione (GSH) depletion. CuO@CaO2 exhibited 2-fold higher GSH depletion rate compared to pristine NSs. The generation oxygen due catalase (CAT)-like decomposition resulted self-propelled diffusion behavior, characteristic fueled nanomotor. These nanostructures both peroxidase (POD)-like and CAT-like activities self-production aqueous media chemical reaction between water. Usage self-supplied POD-like activity amplified toxic hydroxyl (•OH) radicals, enhancing chemodynamic effect within tumor microenvironment (TME). provided source O2 alleviate hypoxic conditions TME. Under near-infrared laser irradiation, photothermal conversion properties, temperature elevation 25 °C. combined led more effective production •OH radicals cell culture medium. function was further an elevated temperature. To assess therapeutic potential, loaded photosensitizer, chlorine e6 (Ce6), evaluated against T98G glioblastoma cells. synergistic combination photodynamic, photohermal, modalities using CuO@CaO2@Ce6 death than 90% under vitro conditions.

Language: Английский

On-demand celastrol delivery by hyaluronic acid-porphyrinic metal-organic frameworks for synergistic sonodynamic/pharmacological antibacterial therapy DOI
Tao Wang,

Jin Zhao,

Mengxing Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140421 - 140421

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nanoparticle‐Based drug delivery strategies for targeted therapy to hypoxic solid tumors DOI

ZhouXue Wu,

Junru Chen,

Biqiong Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158081 - 158081

Published: Nov. 1, 2024

Language: Английский

Citations

3
Electron-reservoir applications of ferrocenes and other late transition-metal sandwich complexes: Flow batteries, sensing, catalysis, and biomedicine DOI
Tiansheng Wang, Didier Astruc

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 524, P. 216300 - 216300

Published: Nov. 9, 2024

Language: Английский

Citations

2
Enhancing wound healing through sonodynamic silver/barium titanate heterostructures-loading gelatin/PCL nanodressings DOI
Yusen Zhang, KeWei Song, Xiaoying Hu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137648 - 137648

Published: Nov. 14, 2024

Language: Английский

Citations

1
Injectable, self-healing and phase change nanocomposite gels loaded with two nanotherapeutic agents for mild-temperature, precise and synergistic photothermal-thermodynamic tumor therapy DOI

Zhiyi Qian,

Shengyang Qi,

Weizhong Yuan

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 877 - 889

Published: Dec. 31, 2024

Language: Английский

Citations

1
The progress and prospect of calcium peroxide nanoparticles in cancer therapy DOI Creative Commons
S Zhang, Chuanchuan He, Chunxia Zhang

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106114 - 106114

Published: Aug. 31, 2024

Language: Английский

Citations

0
Copper(II) Oxide Spindle-like Nanomotors Decorated with Calcium Peroxide Nanoshell as a New Nanozyme with Photothermal and Chemodynamic Functions Providing ROS Self-Amplification, Glutathione Depletion, and Cu(I)/Cu(II) Recycling DOI Creative Commons

Çağıl Zeynep Süngü Akdoğan,

Esin Akbay, Mehmet Ali Onur

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Uniform, mesoporous copper(II) oxide nanospindles (CuO NSs) were synthesized via a method based on templated hydrothermal oxidation of copper in the presence monodisperse poly(glycerol dimethacrylate-co-methacrylic acid) nanoparticles (poly(GDMA-co-MAA) NPs). Subsequent decoration CuO NSs with CaO2 nanoshell (CuO@CaO2 yielded nanozyme capable Cu(I)/Cu(II) redox cycling. Activation cycle by exogenously generated H2O2 from significantly enhanced glutathione (GSH) depletion. CuO@CaO2 exhibited 2-fold higher GSH depletion rate compared to pristine NSs. The generation oxygen due catalase (CAT)-like decomposition resulted self-propelled diffusion behavior, characteristic fueled nanomotor. These nanostructures both peroxidase (POD)-like and CAT-like activities self-production aqueous media chemical reaction between water. Usage self-supplied POD-like activity amplified toxic hydroxyl (•OH) radicals, enhancing chemodynamic effect within tumor microenvironment (TME). provided source O2 alleviate hypoxic conditions TME. Under near-infrared laser irradiation, photothermal conversion properties, temperature elevation 25 °C. combined led more effective production •OH radicals cell culture medium. function was further an elevated temperature. To assess therapeutic potential, loaded photosensitizer, chlorine e6 (Ce6), evaluated against T98G glioblastoma cells. synergistic combination photodynamic, photohermal, modalities using CuO@CaO2@Ce6 death than 90% under vitro conditions.

Language: Английский

Citations

0