Cited by A Review of Polysorbate Quantification and its Degradation Analysis by Liquid Chromatography Coupled with Charged Aerosol Detection

Exploring intranasal drug delivery via nanocarriers: A promising glioblastoma therapy DOI

Vishawambhar Deshmukh,

Nida Sayed Pathan,

Niladri Haldar

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114285 - 114285

Published: Sept. 30, 2024

Language: Английский

Citations

Unraveling the role of the nucleocapsid protein in SARS-CoV-2 pathogenesis: From viral life cycle to vaccine development DOI

Yousra A. El‐Maradny,

Moustafa A. Badawy,

Kareem I. Mohamed

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135201 - 135201

Published: Aug. 30, 2024

Language: Английский

Citations

Long-term interleukin-4 release from 3D printable affinity hydrogels promotes M2-like macrophage polarisation in vitro DOI

George A. Loxley,

Consuelo Coser,

Amir M. Ghaemmaghami

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Localised cytokine delivery is a promising strategy for modulating immune response and enhancing regenerative medicine therapies. SPAK-PEGDA hydrogels enable the long-term controlled release of lysozyme sustained Interleukin-4.

Language: Английский

Citations

Guanidinium/Phenyl-Rich Amphiphilic Cationic Polymer for Efficient Cytosolic Protein Delivery and Cancer Immunotherapy DOI

Nana Feng, Xianghui Cao, Jian Xiao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Protein drugs have garnered increasing attention in biomedical applications due to their high specificity for target receptors and minimal side effects. However, the macromolecular hydrophilic nature of proteins severely hinders ability penetrate cell membranes, restricting intracellular applications. Herein, we present an innovative amphiphilic cationic polymer, p(PG420-co-HP15), capable forming stable nanoparticles with diverse facilitating efficient cytosolic delivery. By incorporating guanidinium phenyl ligands, p(PG420-co-HP15) effectively complexes various via hydrogen bonding, salt bridges, hydrophobic π-π interactions. Meanwhile, ligands further enhance cellular uptake promote endosomal escape by inducing membrane perturbations, likely through disruption phospholipid packing increased fluidity. Consequently, enables delivery 6 proteins, each unique molecular weights, isoelectric points, biological functions across different lines, surpassing commercial reagent PULSin efficiency. Furthermore, constructed nanovaccines ovalbumin (OVA), significantly boosting T cell-mediated antitumor immunity a B16-OVA melanoma mouse model. These findings emphasize potential as versatile protein platform broad disease treatment, vaccine development, research.

Language: Английский

Citations

Spray-drying encapsulation of sunflower pollen peptides using carbohydrate polymers: Physicochemical, antioxidant, structural and morphological analysis DOI

Amir Akbarmehr, Seyed Hadi Peighambardoust,

Leila Pourhasan

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: 8, P. 100622 - 100622

Published: Nov. 28, 2024

Language: Английский

Citations

Comprehensive insight into exploring the potential of microbial enzymes in cancer therapy: Progress, challenges, and opportunities: A review DOI

F. Hassan,

Esmail M. El‐Fakharany, Yousra A. El‐Maradny

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134535 - 134535

Published: Aug. 5, 2024

Language: Английский

Citations

A Review of Polysorbate Quantification and its Degradation Analysis by Liquid Chromatography Coupled with Charged Aerosol Detection DOI

Lei Shi,

Guobin Shen,

Ruiping Chai

et al.

Journal of Chromatography A, Journal Year: 2024, Volume and Issue: 1742, P. 465651 - 465651

Published: Dec. 31, 2024

Language: Английский

Citations