Structural characteristics and intestinal flora metabolism mediated immunoregulatory effects of Lactarius deliciosus polysaccharide
Xiaodan Dong,
No information about this author
Sujun Sun,
No information about this author
Xinkun Wang
No information about this author
et al.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
278, P. 135063 - 135063
Published: Aug. 24, 2024
Language: Английский
Polysaccharides from Sea Cucumber (Stichopus japonicus) Synergize with Anti-PD1 Immunotherapy to Reduce MC-38 Tumor Burden in Mice Through Shaping the Gut Microbiome
Jiahui Li,
No information about this author
Jinhui Jia,
No information about this author
Yue Teng
No information about this author
et al.
Foods,
Journal Year:
2025,
Volume and Issue:
14(3), P. 387 - 387
Published: Jan. 24, 2025
Immune
checkpoint
inhibitors
(ICIs)
have
revolutionized
cancer
treatment
and
significantly
improved
outcomes
for
patients
with
certain
malignancies.
However,
immunotherapy
ICIs
is
only
effective
in
a
subset
of
the
gut
microbiota
been
identified
as
an
important
factor
associated
response
to
ICI
therapy.
Polysaccharides
from
sea
cucumber
(Stichopus
japonicus)
(SCP)
shown
modulate
exhibit
beneficial
health
functions,
but
whether
SCP
could
synergize
anti-PD1
remains
unexplored.
In
this
study,
mice
ICI-sensitive
MC38
tumors
were
treated
antibody
after
supplementation
or
without
examine
potential
impact
on
efficacy
immunotherapy.
strongly
amplified
anti-tumor
activity
tumor-bearing
mice.
Flow
cytometry
immunohistological
staining
demonstrated
that
increased
cytotoxic
CD8+
T
lymphocytes
while
decreasing
regulatory
Foxp3+
CD4+
lymphocytes.
Gut
metabolomic
analysis
revealed
modulated
abundance
metabolites
such
indole-3-carboxylic
acid.
Furthermore,
fecal
transplantation
experiments
justified
synergistic
effect
was
partially
mediated
through
microbiota.
Mice
receiving
SCP-treated
showed
boosted
anti-PD1,
along
enhanced
immunity.
These
findings
indicate
be
utilized
dietary
strategy
combined
therapy
achieve
patients.
Language: Английский
Structure characterization of polysaccharide isolated from Ribes nigrum L. and it's bioactivity against gout
Xianjun Huang,
No information about this author
Sitao Zheng,
No information about this author
Yujia Guo
No information about this author
et al.
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown, P. 141359 - 141359
Published: Feb. 1, 2025
Language: Английский
CO2-responsive ionic liquid for the sustainable extraction and separation of Rosa roxburghii polysaccharides
Zhonghai Tang,
No information about this author
Yingjun Chen,
No information about this author
Changyong Cai
No information about this author
et al.
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown, P. 142708 - 142708
Published: March 1, 2025
Language: Английский
Improved the physicochemical properties and bioactivities of oligosaccharides by degrading self-extracting/commercial ginseng polysaccharides
Tao Li,
No information about this author
Qi Wu,
No information about this author
He Liu
No information about this author
et al.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
279, P. 135522 - 135522
Published: Sept. 10, 2024
Language: Английский
Soybean hull polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet-fed zebrafish
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown, P. 141123 - 141123
Published: Feb. 1, 2025
Language: Английский
Physalis peruviana heteropolysaccharide-conjugated selenium nanoparticles: Preparation, characterization, and promising applications in cancer therapy
Kai Sun,
No information about this author
Lingling Ma,
No information about this author
Jiantong Hou
No information about this author
et al.
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown, P. 141639 - 141639
Published: March 1, 2025
Language: Английский
Effective mechanism of polysaccharides from Erxian herbal pair in promoting bone repair in traumatic osteomyelitis by activating osteoblast GPR41 and inhibiting the MEK/ERK/MAPK signalling axis
Yun Zhou,
No information about this author
Meng Li,
No information about this author
Cheng Yan Li
No information about this author
et al.
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown, P. 141858 - 141858
Published: March 1, 2025
Language: Английский
Structural differences in novel pectic polysaccharides from Rosa roxburghii Tratt drive distinct gut microbiota profiles: Evidence from in vitro fecal fermentation
Han Qiu,
No information about this author
Ang-Xin Song,
No information about this author
You Luo
No information about this author
et al.
Food Hydrocolloids,
Journal Year:
2025,
Volume and Issue:
unknown, P. 111381 - 111381
Published: March 1, 2025
Language: Английский
Effect of fermentation of edible mushroom on the nutrition of Pueraria lobata and coix seed beverage
Yan Yuan,
No information about this author
Xia Chen,
No information about this author
Laping He
No information about this author
et al.
Journal of Food Measurement & Characterization,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 25, 2025
Language: Английский
