Exploiting the Molecular Properties of Fibrinogen to Control Bleeding Following Vascular Injury

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1336 - 1336

Published: Feb. 5, 2025

The plasma protein fibrinogen is critical for haemostasis and wound healing, serving as the structural foundation of blood clot. Through a complex interaction between coagulation factors, soluble converted to insoluble fibrin networks, which form skeleton clot, an essential step limit loss after vascular trauma. This review examines molecular mechanisms by modulates bleeding, focusing on its interactions with other proteins that maintain network stability prevent premature breakdown. Moreover, we also cover role in ensuring clot through physiological platelets. We address therapeutic applications across various clinical contexts, including trauma-induced coagulopathy, postpartum haemorrhage, cardiac surgery. Importantly, full understanding function will allow development new therapeutics following trauma, remains key cause mortality worldwide. While current management strategies help injury, they are far from perfect future research should prioritise refining replacement developing novel agents stabilise network. Exploiting fibrinogen’s properties holds significant potential improving outcomes trauma care, surgical interventions obstetric haemorrhage.

Language: Английский

Emerging elastic micro-nano materials for diagnosis and treatment of thrombosis

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Thrombus is a blood clot that forms in vessel at the point of flaking. Thrombosis closely associated with cardiovascular diseases caused by different sources and factors. However, current clinical methods thrombus diagnosis treatment still have problems targeting, permeability, stability, biosafety. Therefore, recent years, based on development micro/nano technology, researchers tried to develop some new strategies for thrombosis. Due unique structural characteristics, micro-nano materials physiological environments show excellent transport delivery properties such as better vivo circulation, longer life span, targeting ability, controllable cellular internalization. Especially, elasticity stiffness are inherent mechanical well-designed materials, which can make them adapted needs thrombosis treatment. Herein, this review first introduces thrombotic microenvironment characterize process. Then, fine-tune pathological occurrence thrombosis, role elastic summarized. The properties, preparation methods, biological fate these been discussed detail. Following, applications biomedical imaging, drug delivery, therapy highlighted. Last, shortcomings future design discussed. This will provide ideas use nanotechnology future.

Language: Английский

Bioactive hemostatic materials: a new strategy for promoting wound healing and tissue regeneration

MedComm, Journal Year: 2025, Volume and Issue: 6(4)

Published: March 22, 2025

Abstract Wound healing remains a critical global healthcare challenge, with an annual treatment cost exceeding $50 billion worldwide. Over the past decade, significant advances in wound care have focused on developing sophisticated biomaterials that promote tissue regeneration and prevent complications. Despite these developments, there crucial need for multifunctional materials can effectively address complex, multiphase nature of repair while being effective easily applicable various clinical settings. This review systematically analyzes latest developments materials, examining their chemical composition, structural design, therapeutic mechanisms. We comprehensively evaluate bioactive components, including natural polymers, synthetic matrices, hybrid composites, along different forms, such as hydrogels, powders, smart dressings. Special attention is given to emerging strategies material design integrate multiple functions, sustained drug delivery, infection prevention, promotion. The insights provided this illuminate path toward next‐generation highlighting opportunities more solutions significantly improve patient outcomes reduce burden.

Language: Английский