Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders DOI Open Access
Anyuan Zhang, Qiubai Li, Zhichao Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 225 - 225

Published: Dec. 30, 2024

The global issue of aging populations has become increasingly prominent, thus the research and development for anti-aging therapies to assure longevity as well ameliorate age-related complications is put high on agenda. young humoral milieu been substantiated impart youthful characteristics aged cells or organs. Extracellular vesicles (EVs) are a heterogeneous group cell-derived membrane-limited structures that serve couriers proteins genetic material regulate intercellular communication. Of note, EVs appeared be an indispensable component blood in prolonging lifespans, circulating have indicated mediate beneficial effect aging. Human umbilical cord mesenchymal stem (HUCMSC-EVs), isolated from youngest adult cell source, speculated reproduce function partially revitalize numerous organs old animals. Robust evidence suggested HUCMSC-EVs muti-target therapeutic agents combating alleviating degenerative disorders. Here, we provide comprehensive overview effects brain, heart, vasculature, kidney, muscle, bone, other Furthermore, critically discuss current investigation engineering strategies HUCMSC-EVs, intending unveil their full potential field research.

Language: Английский

Advances in the development of medical dressings for the treatment of diabetic foot wounds DOI
Ming Cai, Zhao Liu,

Xun Sun

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155575 - 155575

Published: Sept. 7, 2024

Language: Английский

Citations

5
Biomimetic scaffolds loaded with mesenchymal stem cells (MSCs) or MSC-derived exosomes for enhanced wound healing DOI Creative Commons
Alireza Ghasempour, Hamideh Dehghan, Mahmoud Mahmoudi

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 9, 2024

Since wound healing is one of the most important medical challenges and common dressings have not been able to manage this challenge well today, efforts increased achieve an advanced dressing. Mesenchymal stem cells exosomes derived from them shown high potential in regenerating wounds due their immunomodulatory, anti-inflammatory, immunosuppressive, regenerative capacities. However, such as short life these cells, low durability area, stability resulted limitations use for healing. Nowadays, different scaffolds are considered suitable biomaterials These made natural or synthetic polymers promising ideal dressing that does disadvantages dressings. One strategies has attracted much attention today using seeding delivering MSCs exosomes. This combined strategy a enhancing shelf increasing In review, combination with comprehensively discussed.

Language: Английский

Citations

5
Rhein-loaded chitosan nanoparticles for treatment of MRSA-infected wound DOI

Shuang Cai,

Linlin Wang,

Xilong Cui

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135360 - 135360

Published: Sept. 5, 2024

Language: Английский

Citations

4
Mussel-inspired bifunctional chimeric peptides macromolecules functionalize 3D-printed porous scaffolds for enhanced antimicrobial and osseointegration properties in bone defect repair DOI

Ziyang Bai,

Yifan Zhao,

Wenjun Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142668 - 142668

Published: March 1, 2025

Language: Английский

Citations

0
The Role of Exosomes Derived from Various Sources in Facilitating the Healing of Chronic Refractory Wounds DOI Creative Commons

Fengdan Xu,

Qiling Zhang, Yuling Liu

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107753 - 107753

Published: April 1, 2025

Language: Английский

Citations

0
Injectable decellularized Wharton's jelly hydrogel containing CD56+ umbilical cord mesenchymal stem cell-derived exosomes for meniscus tear healing and cartilage protection DOI Creative Commons

Simiao Kang,

Xin Shi, Yong Chen

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101258 - 101258

Published: Sept. 19, 2024

Language: Английский

Citations

3
Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders DOI Open Access
Anyuan Zhang, Qiubai Li, Zhichao Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 225 - 225

Published: Dec. 30, 2024

The global issue of aging populations has become increasingly prominent, thus the research and development for anti-aging therapies to assure longevity as well ameliorate age-related complications is put high on agenda. young humoral milieu been substantiated impart youthful characteristics aged cells or organs. Extracellular vesicles (EVs) are a heterogeneous group cell-derived membrane-limited structures that serve couriers proteins genetic material regulate intercellular communication. Of note, EVs appeared be an indispensable component blood in prolonging lifespans, circulating have indicated mediate beneficial effect aging. Human umbilical cord mesenchymal stem (HUCMSC-EVs), isolated from youngest adult cell source, speculated reproduce function partially revitalize numerous organs old animals. Robust evidence suggested HUCMSC-EVs muti-target therapeutic agents combating alleviating degenerative disorders. Here, we provide comprehensive overview effects brain, heart, vasculature, kidney, muscle, bone, other Furthermore, critically discuss current investigation engineering strategies HUCMSC-EVs, intending unveil their full potential field research.

Language: Английский

Citations

2