International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 14143 - 14169
Published: Dec. 1, 2024
Breast
cancer
surgery
plays
a
pivotal
role
in
the
multidisciplinary
approaches.
Surgical
techniques
and
objectives
are
gradually
shifting
from
tumor
complete
resection
towards
prolonging
survival,
improving
cosmetic
outcomes,
restoring
social
psychological
well-being
of
patients.
However,
surgical
treatment
still
faces
challenges
such
as
inadequate
sensitivity
sentinel
lymph
node
localization,
need
to
improve
intraoperative
boundary
localization
imaging,
postoperative
scar
healing,
risk
recurrence,
necessitating
other
adjunct
measures
for
improvement.
To
address
these
challenges,
specificity-optimized
nanomedicines
have
been
introduced
into
therapeutic
landscape
breast
cancer.
In
particular,
this
review
involves
starting
with
an
overview
structure
composition
microenvironment
then
introducing
guiding
principle
foundation
design
nanomedicine.
Moreover,
we
will
take
order
process
diagnosis
point,
adaptively
propose
roles
advantages
nanomedicine
addressing
corresponding
issues.
Furthermore,
also
involved
prospects
utilizing
advanced
technological
Overall,
seeks
uncover
sophisticated
strategies
clinical
standpoint,
faced
treatment,
provide
insights
subject
matter.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(2), P. 207 - 207
Published: Jan. 7, 2025
The
scientific
interest
in
the
chemical
modification
of
chitosan
to
increase
its
solubility
and
application
has
led
conjugation
with
Schiff
bases,
which
are
interesting
scaffolds
endowed
diverse
biological
properties.
resultant
chitosan-based
bases
(CSBs)
widely
studied
literature
due
myriad
activities
exerted,
both
catalytic
biological,
including
anticancer,
anti-inflammatory,
antioxidant,
especially
antimicrobial
ones.
Antimicrobial
resistance
(AMR)
is
one
major
public
health
challenges
twenty-first
century
because
it
represents
a
threat
prevention
treatment
growing
number
bacterial,
parasitic,
viral,
fungal
infections
that
no
longer
treatable
available
drugs.
Thus,
this
review,
we
present
brief
outline
CSBs
as
well
their
complexes
metals,
particular
focus
on
recent
regarding
effect
these
captivating
derivatives.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 705 - 705
Published: Feb. 5, 2025
This
study
investigated
the
potential
effects
of
corn
protein
activity
peptides
(CPAPs)
on
inflammation
response
levels
and
gastrointestinal
microbiota
in
Helicobacter
pylori
(H.
pylori)
infection
mice.
CPAPs
significantly
up-regulated
mRNA
expression
anti-inflammatory
factor
IL-10
down-regulated
pro-inflammatory
factors
TGF-β,
TLR4,
MyD88,
NF-κB,
indicating
that
may
antagonize
H.
pylori-induced
inflammatory
responses
by
inhibiting
NF-κB
signaling
pathways.
Through
intervention
CPAPs,
colonization
stomach
was
reduced.
Additionally,
structural
composition
improved,
with
an
increase
abundance
diversity.
These
changes
positively
regulate
disorders
In
addition,
PICRUST
function
prediction
intestinal
revealed
prevent
or
reduce
metabolic
brought
about
pylori,
which
improve
biometabolic
pathways
modulating
composition.
conclusion,
these
findings
suggest
mitigate
induced
offering
theoretical
support
for
development
corn-protein-based
functional
foods.
Journal of Applied Polymer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
ABSTRACT
Excessive
exudate
within
the
wound
can
readily
result
in
fluid
retention
and
bacterial
infection.
Carboxymethyl
chitosan
(CMCS)
nonwoven
effectively
absorb
excess
exudate,
providing
a
moist
environment
for
healing.
However,
CMCS
shows
poor
antimicrobial
activity
neutral
or
weakly
alkaline
environment,
absorbent
gel
property
of
makes
its
wet
antibacterial
modification
very
difficult.
Therefore,
Zn‐coated
dressings
(Zn@CMCS)
with
management
properties
were
prepared
by
template‐assisted
magnetron
sputtering.
The
Zn
5
@CMCS
sputtering
time
min
have
excellent
air
permeability
(>
6000
mm/s),
high
swelling
degree
(~2500%),
superior
transition
properties.
Moreover,
exhibits
significant
against
Staphylococcus
aureus
Escherichia
coli
.
Additionally,
benefiting
from
low
coating
area
(~18%),
cytocompatibility.
This
study
provides
insights
into
nonwet
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 12079 - 12098
Published: Nov. 1, 2024
Metastasis-initiating
cells
are
key
players
in
progression,
resistance,
and
relapse
of
colorectal
cancer
(CRC),
by
leveraging
the
regulatory
relationship
between
Transforming
Growth
Factor-beta
(TGF-β)
signaling
anti-L1
cell
adhesion
molecule
(L1CAM).
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(18), P. 4590 - 4606
Published: Jan. 1, 2024
Nanomedicine
has
emerged
as
a
promising
avenue
for
advancing
cancer
treatment,
but
the
challenge
of
mitigating
its
in
vivo
side
effects
necessitates
development
innovative
structures
and
materials.
Recent
investigation
unveiled
nanogels
particularly
compelling
candidates,
characterized
by
porous,
three-dimensional
network
architecture
that
exhibits
exceptional
drug
loading
capacity.
Beyond
this,
boast
substantial
specific
surface
area
can
be
tailored
with
chemical
functionalities.
Consequently,
are
frequently
engineered
multi-modal
synergistic
platform
combating
cancer,
wherein
photothermal
therapy
stands
out
due
to
capacity
penetrate
deep
tissues
achieve
localized
tumor
eradication
through
application
elevated
temperatures.
In
this
review,
we
delve
into
synthesis
diverse
varieties
capable
controlled
release
triggered
either
or
physical
stimuli.
It
also
summarizes
their
potential
integration
alongside
other
therapeutic
modalities
realize
effective
ablation.
Moreover,
analyze
primary
mechanisms
underlying
contribution
treatment
while
underscoring
adeptness
regulating
temperatures
repairing
bone
defects
resulting
from
tumor-associated
trauma.
Envisioned
an
auspicious
strategy
realm
therapy,
hold
promise
furnishing
delivery
precise
thermal
ablation
capabilities.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 9689 - 9705
Published: Sept. 1, 2024
Epidermal
growth
factor
receptor
(EGFR)
is
a
major
target
for
the
treatment
of
colorectal
cancer.
Thus,
anti-EGFR
antibody
conjugated
lipid-polymer
hybrid
nanoparticles
can
offer
potential
means
enhancing
efficacy
chemotherapeutics
in
EGFR
overexpressing
cancers.
In
addition,
combination
chemotherapy
and
photothermal
therapy
promising
strategy
cancer
treatment.
Hence,
it
highly
desirable
to
develop
safe
effective
delivery
system
tumor
therapy.
