Hydroxyapatite/Silk Fibroin Composite Scaffold with a Porous Structure and Mechanical Strength Similar to Cancellous Bone by Electric Field-Induced Gel Technology DOI
Yun‐Fei Shao, Hui Wang,

Yiran Zhu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(44), P. 60977 - 60991

Published: Oct. 25, 2024

Repair and regeneration of bone tissue defects is a multidimensional process that has been highly challenging to date. The artificial scaffold materials, which play core role, still face the conflict biofriendly porous structure will reduce mechanical performance accelerate degradation. Herein, multistage structured hydroxyapatite (HA)/silk fibroin (SF) composite (e-HA/SF) was successfully constructed by cleverly utilizing electric field-induced gel technology. results indicated prepared e-HA/SF scaffolds possess biomimetic hierarchical structures with suitable porosity similar cancellous bone. HA nanocrystals were uniformly encapsulated in three-dimensional space scaffold, thus endowing an enhanced performance. Notably, maximum compression stress Young's modulus e-HA/SF-2 can reach 24.66 ± 0.88 28.91 3.19 MPa, respectively, are equivalent those Such enhancement previously unattainable through conventional freeze-drying strategies. Moreover, introduction bioactive nano-HA trigger optimal cell response both static dynamic culture experiments vitro. developed this study better balance between degradation properties scaffolds.

Language: Английский

Review on application of silk fibroin hydrogels in the management of wound healing DOI

Chang Kuk You,

C. Wang,

Zhenjiang Ma

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 298, P. 140082 - 140082

Published: Jan. 18, 2025

Language: Английский

Citations

3
Silk fibroin for cosmetic dermatology DOI
Songjie Li, Han Chen,

Xin Dan

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159986 - 159986

Published: Jan. 1, 2025

Citations

1
Toward the Production of Hydroxyapatite/Poly(Ether-Ether-Ketone) (PEEK) Biocomposites: Exploring the Physicochemical, Mechanical, Cytotoxic and Antimicrobial Properties DOI Open Access

Meirilany Rozeno Costa,

José Adeilton Carvalho Filho,

Carlos Bruno Barreto Luna

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(17), P. 2520 - 2520

Published: Sept. 5, 2024

The development of hydroxyapatite (HAp) and polyether ether ketone (PEEK) biocomposites has been extensively studied for bone repair applications due to the synergistic properties involved materials. In this study, we aimed develop HAp/PEEK using high-energy ball milling, with HAp concentrations (20%, 40%, 60% w/v) in PEEK, evaluate their physicochemical, mechanical, cytotoxicity, antimicrobial potential Tissue Engineering (TE). were characterized by structure, morphology, apparent porosity, diametral compression strength, activity. study results demonstrated that successfully synthesized. C2 biocomposite, containing 40% HAp, stood out optimal distribution particles PEEK matrix, resulting higher strength (246 MPa) a homogeneous microstructure. It exhibited activity against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, no cytotoxicity observed. These make biocomposite promising regenerative medicine applications, combining mechanical bioactivity, biocompatibility.

Language: Английский

Citations

3
Mechanism of remediation of U(VI) contaminated simulated soil by AC‐nHAP gel microsphere as PRB combined electrokinetic technology DOI

Shukui Zhou,

Yuewu Yang,

Hui Tang

et al.

Journal of Radioanalytical and Nuclear Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Language: Английский

Citations

0
Hydroxyapatite/Silk Fibroin Composite Scaffold with a Porous Structure and Mechanical Strength Similar to Cancellous Bone by Electric Field-Induced Gel Technology DOI
Yun‐Fei Shao, Hui Wang,

Yiran Zhu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(44), P. 60977 - 60991

Published: Oct. 25, 2024

Repair and regeneration of bone tissue defects is a multidimensional process that has been highly challenging to date. The artificial scaffold materials, which play core role, still face the conflict biofriendly porous structure will reduce mechanical performance accelerate degradation. Herein, multistage structured hydroxyapatite (HA)/silk fibroin (SF) composite (e-HA/SF) was successfully constructed by cleverly utilizing electric field-induced gel technology. results indicated prepared e-HA/SF scaffolds possess biomimetic hierarchical structures with suitable porosity similar cancellous bone. HA nanocrystals were uniformly encapsulated in three-dimensional space scaffold, thus endowing an enhanced performance. Notably, maximum compression stress Young's modulus e-HA/SF-2 can reach 24.66 ± 0.88 28.91 3.19 MPa, respectively, are equivalent those Such enhancement previously unattainable through conventional freeze-drying strategies. Moreover, introduction bioactive nano-HA trigger optimal cell response both static dynamic culture experiments vitro. developed this study better balance between degradation properties scaffolds.

Language: Английский

Citations

0