Chemosphere, Journal Year: 2025, Volume and Issue: 373, P. 144161 - 144161
Published: Jan. 28, 2025
Language: Английский
Environmental Sciences Europe, Journal Year: 2023, Volume and Issue: 35(1)
Published: March 23, 2023
Abstract Background Per- and polyfluorinated alkyl substances (PFAS) have received increasing scientific political attention in recent years. Several thousand commercially produced compounds are used numerous products technical processes. Due to their extreme persistence the environment, humans all other life forms are, therefore, increasingly exposed these substances. In following review, PFAS will be examined comprehensively. Results The best studied carboxylic sulfonic acids with chain lengths of C4 C14, particularly perfluorooctanoic acid (PFOA) perfluorooctane (PFOS). These harmful aquatic fauna, insects, amphibians at concentrations a few µg/L or less, accumulate organisms, biomagnify food webs. Humans, as final link chains, subjected uptake primarily through drinking water. multiple toxic effects, affecting liver, kidney, thyroid, immune system. latter effect is basis for establishment tolerable weekly dose only 4.4 ng/kg body weight sum four representatives PFOA, PFOS, perfluorononanoic (PFNA) perfluorohexane (PFHxS) by European Food Safety Authority (EFSA) 2020. Exposure estimates human biomonitoring show that this value frequently reached, many cases exceeded. major challenge analysis, especially waste: single-substance analyses capture fragment large, diverse family PFAS. As consequence, parameters gained importance. high mobility per makes soil groundwater pollution contaminated sites problem. general, short-chain more mobile than long-chain ones. Processes purification water treatment often ineffective expensive. Recycling PFAS-containing such paper packaging leads carryover contaminants. Incineration requires temperatures completely destroy After PFOS perfluorinated were regulated internationally, manufacturers users switched PFAS: representatives, per- oxo acids, telomeric alcohols acids. Analytical studies an increase environmental chemicals. Ultra-short (chain length C1–C3) not been well studied. Among others, trifluoroacetic (TFA) present globally rapidly concentrations. Conclusions substitution individual recognized hazardous possibly equally virtually unknown chronic toxicity can, solution. answer switch fluorine-free alternatives applications which essential.
Language: Английский
Citations
162
Environmental Research, Journal Year: 2022, Volume and Issue: 220, P. 115165 - 115165
Published: Dec. 28, 2022
Per- and polyfluoroalkyl substances, or PFAS, gained significant public regulatory attention due to widespread contamination health harms associated with exposure. Ingestion of PFAS from contaminated food water results in the accumulation body is considered a key route human Here we calculate potential contribution PFOS consumption locally caught freshwater fish serum levels. We analyzed data for over 500 composite samples fillets collected across United States 2013 2015 under U.S. EPA's monitoring programs, National Rivers Streams Assessment Great Lakes Human Health Fish Fillet Tissue Study. The two datasets indicate that an individual's potentially source exposure perfluorinated compounds. median level total targeted rivers streams was 9,500 ng/kg, 11,800 ng/kg Lakes. largest contributor levels, averaging 74% total. levels detected were 278 times higher than commercially relevant tested by Food Drug Administration 2019–2022. Exposure assessment suggests single serving per year as EPA programs translates into increase blood serum. chemical pollutants case environmental injustice especially affects communities depend on fishing sustenance traditional cultural practices. Identifying reducing sources urgent priority.
Language: Английский
Citations
81
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: March 13, 2024
Although adverse environmental exposures are considered a major cause of chronic diseases, current studies provide limited information on real-world chemical and related risks. For this study, we collected serum samples from 5696 healthy people patients, including those with 12 in China completed biomonitoring 267 chemicals via gas liquid chromatography-tandem mass spectrometry. Seventy-four highly frequently detected were used for exposure characterization risk analysis. The results show that region is the most critical factor influencing human levels, followed by age. Organochlorine pesticides perfluoroalkyl substances associated multiple some them exceed safe ranges. Multi-exposure models reveal significant effects hyperlipidemia, metabolic syndrome hyperuricemia. Overall, study provides comprehensive exposome atlas disease information, which can guide subsequent in-depth cause-and-effect between health.
Language: Английский
Citations
24
Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 120916 - 120916
Published: Jan. 1, 2025
Language: Английский
Citations
5
Toxics, Journal Year: 2025, Volume and Issue: 13(2), P. 134 - 134
Published: Feb. 12, 2025
Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals widely used in consumer industrial products due to their unique physicochemical properties. However, persistence bioaccumulative potential pose significant environmental human health risks. This review focuses on the use of non-invasive matrices-urine, hair, nails-for biomonitoring PFAS, highlighting key findings from scientific studies. While urine offers a practical option, its limited sensitivity for long-chain PFAS requires further analytical advances. Hair nails have demonstrated biomonitoring, with higher detection frequencies concentrations certain compared urine. The variability levels across studies reflects differences population characteristics, exposure sources, geographic regions. emphasizes need standardized methods, expanded studies, complementary matrices enhance accuracy reliability assessment.
Language: Английский
Citations
3
Environmental Health, Journal Year: 2023, Volume and Issue: 22(1)
Published: May 10, 2023
Per- and polyfluoroalkyl substances (PFAS) are used for their properties such as stain water resistance. The have been associated with adverse health outcomes in both pregnant mothers infants, including pre-eclampsia low birthweight. A growing body of research suggests that PFAS transferred from mother to fetus through the placenta, leading utero exposure. systematic review was performed using PubMed database search studies evaluating determinants concentrations blood matrices neonates shortly after birth. Studies were included this if an observational study design utilized, exposure at least one analyte measured, measured maternal or neonatal matrices, determinant assessed, results beta estimates provided. We identified 35 inclusion evaluated relationships among factors collected these studies. Parity, breastfeeding history, race country origin, household income had strongest most consistent evidence support roles certain mothers. Reported findings on smoking status, alcohol consumption, pre-pregnancy mass index (BMI) suggest not important neonates. Further into informative consumer product use, detailed dietary information, consumed sources potential is needed. Research critical estimate past exposure, build improved models, further our understanding dose-response relationships, which can influence epidemiological risk assessment evaluations. Given exposed PFAS, it identify understand better implement public interventions populations.
Language: Английский
Citations
43
Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 20, 2023
As emerging organic contaminants, per- and polyfluoroalkyl substances (PFASs) have aroused worldwide concern due to their environmental persistence, ubiquitous presence, bioaccumulation, potential toxicity. It has been demonstrated that PFASs can accumulate in human body cause multiple adverse health outcomes. Notably, detected the semen of human, posing a hazard male fecundity. This article reviews evidence about toxic effects exposure on reproduction, focusing sperm quality. Epidemiological studies showed PFASs, such as perfluorooctanoic acid (PFOA) perfluorooctane sulfonic (PFOS), were adversely associated with parameters humans, including count, morphology motility. Experimental results also confirmed PFAS led testicular epididymal damage, therefore impairing spermatogenesis The mechanisms reproductive toxicity may be involved blood-testosterone barrier destruction, apoptosis, testosterone synthesis disorder, membrane lipid composition alteration, oxidative stress Ca 2+ influx sperm. In conclusion, this review highlighted threat spermatozoa.
Language: Английский
Citations
30
International Journal of Hygiene and Environmental Health, Journal Year: 2023, Volume and Issue: 250, P. 114168 - 114168
Published: April 15, 2023
Per- and polyfluoroalkyl substances (PFASs) were one of the priority substance groups selected which have been investigated under ambitious European Joint programme HBM4EU (2017-2022). In order to answer policy relevant questions concerning exposure health effects PFASs in Europe several activities developed namely i) synthesis HBM data generated prior by developing new platforms, ii) development a Quality Assurance/Quality Control Program covering 12 biomarkers PFASs, iii) aligned harmonized human biomonitoring studies PFASs. addition, some cohort (on mother-child exposure, occupational hexavalent chromium) initiated, literature researches on risk assessment mixtures PFAS, effect performed. The Aligned Studies internal reference levels for 1957 teenagers aged 12-18 years. results showed that serum 14.3% exceeded 6.9 μg/L corresponds EFSA guideline value tolerable weekly intake (TWI) 4.4 ng/kg (PFOA, PFOS, PFNA PFHxS). Northern Western Europe, 24% this level. most sources identified drinking water foods (fish, eggs, offal locally produced foods). also revealed very high workers (P95: 192 chrome plating facilities), highlighting importance monitoring specific workplaces. environmental contaminated hotspots causing population identified. conclusion, frequent evidenced strongly suggests need take all possible measures prevent further contamination population, addition adopting remediation hotspot areas, protect environment. findings support restriction whole group Further, research definition additional toxicological dose-effect relationship values more compounds is needed.
Language: Английский
Citations
24
npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)
Published: Oct. 6, 2024
Per- and polyfluoroalkyl substances (PFAS) pose an emerging environmental risk impacting food products ecosystems. This study analyzes over 150,000 entries from safety authorities scientific publications 2017 onwards. Our findings show that fish & seafood, biota have the highest PFAS concentrations due to contamination bioaccumulation. Surface water samples also frequently contain PFAS, raising concerns about long-term ecological human health effects. Comprehensive strategies are essential mitigate these risks.
Language: Английский
Citations
11
Applied Sciences, Journal Year: 2023, Volume and Issue: 13(11), P. 6696 - 6696
Published: May 31, 2023
More than 7000 synthetic compounds known as per- and poly-fluoroalkyl substances (PFAS) are applied to food packaging other materials provide fat, fire, and/or water resistance properties. These have exceptional environmental stability persistence due the strong C-F chemical bond, earning them moniker “forever chemicals”. Emission of PFAS from industrial waste leads water, air, soil contamination. Due this ubiquitous nature, combined with fact that in humans carcinogenic reprotoxic effects cause vaccine depression immunity system, may constitute a major threat human health. For reason, attention scientific community control bodies is increasing consequence legislation literature on constantly evolving. This review aims comprehensive overview state art about current addressing PFAS; targeted screening method for identification, detection quantification toxicity contamination matrices contact matrices. A latest research recent developments will insights into understanding its health implications. Moreover, it serve valuable reference further studies related could help informing future policy decisions.
Language: Английский
Citations
20