Sub-acute exposure of male guppies (Poecilia reticulata) to environmentally relevant concentrations of PFOA and GenX induces significant changes in the testis transcriptome and reproductive traits

Environment International, Journal Year: 2024, Volume and Issue: 187, P. 108703 - 108703

Published: April 26, 2024

Poly- and perfluoroalkyl substances (PFAS) are frequently detected in the environment linked to adverse reproductive health outcomes humans. Although legacy PFAS have been phased out due their toxicity, alternative increasingly used despite fact that information on toxic effects traits is particularly scarce. Here, we exposed male guppies (Poecilia reticulata) for a short period (21 days) an environmentally realistic concentration (1 ppb) of PFOA, PFAS, its replacement compound, GenX, assess impact gene expression. Exposure did not impair survival but instead caused sublethal effects. Overall, exposure changes sexual behaviour had detrimental sperm motility. Sublethal variations were also seen at transcriptional level, with modulation genes involved immune regulation, spermatogenesis, oxidative stress. We observed bioaccumulation which was higher PFOA than GenX. Our results offer comprehensive comparison these two shed light toxicity newly emerging PFAS. It therefore evident even low concentrations exposure, can subtle yet significant behaviour, fertility, immunity. These findings underscore potential ramifications pollution under natural conditions fish populations.

Language: Английский

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Adverse health effects of exposure to plastic, microplastics and their additives: environmental, legal and policy implications for Israel

Israel Journal of Health Policy Research, Journal Year: 2024, Volume and Issue: 13(1)

Published: Sept. 10, 2024

Abstract Background Israel is a regional "hotspot" of plastic pollution, with little discussion potential adverse health effects from exposure to plastic. This review aims stimulate and drive policy by focusing on these effects. Main body Plastics are synthetic polymers containing additives which can leach food- beverage-contact into our food beverages, textiles onto skin. persist in the environment for generations, fragmenting MNPs: Micro (1 micron–5 mm)-Nano nm–1 micron)-Plastic, contaminate atmosphere, water, chain. MNP enter human through ingestion, inhalation touch. < 10 microns cross epithelial barriers respiratory gastrointestinal systems, fragments 100 nm intact skin, enabling entry tissues. have been found multiple organs body. Patients atheromas carotid arteries increased risk combined measure stroke, cardiovascular disease, death. Toxic plastics include bisphenols, phthalates, PFAS, endocrine-disrupting chemicals (EDCs) cause dysregulation thyroid function, reproduction, metabolism, including obesity, diabetes, endometriosis, cancer, decreased fertility, sperm count quality. Fetal EDCs associated rates miscarriages, prematurity low birth weight. There likely no safe level EDCs, increasing evidence trans-generational epigenetic several existing Israeli laws reduce use waste. Taxes single-use (SUP) were recently cancelled. many gaps regulatory standards food-, beverage- child- Existing poorly enforced. Conclusion Reduction production plastic, promotion recycling reduction leaching toxic beverages essential goals. Specific recommendations: Periodic monitoring bottled food, indoor air; Strengthen enforcement beverage-, child-safe plastic; Renew tax SUPs; National ban SUP at public beaches, nature reserves parks; Ban products manufactured MNP; Increase research sources outcomes EDCs.

Language: Английский

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Perfluorooctane sulfonate and perfluorooctanoic acid inhibit progesterone-responsive capacitation through cAMP/PKA signaling pathway and induce DNA damage in human sperm

Environmental Toxicology and Pharmacology, Journal Year: 2023, Volume and Issue: 100, P. 104165 - 104165

Published: May 27, 2023

Language: Английский

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Contemporary Concise Review 2023: Environmental and occupational lung diseases

Respirology, Journal Year: 2024, Volume and Issue: 29(7), P. 574 - 587

Published: June 3, 2024

SUMMARY OF KEY POINTS Air pollutants have various effects on human health in environmental and occupational settings. can be a risk factor for incidence, exacerbation/aggravation death due to lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), hypersensitivity pneumonitis or pneumonia (HP), fibrosis such as pneumoconiosis malignant respiratory diseases cancer pleural mesothelioma. Environmental are crucial clinical social issues worldwide, although the burden of causes varies depending country/region, demographic variables, geographical location, industrial structure socioeconomic situation. The correct recognition taking appropriate measures essential their effective prevention.

Language: Английский

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Exploring the environmental contamination toxicity and potential carcinogenic pathways of perfluorinated and polyfluoroalkyl substances (PFAS): an integrated network toxicology and molecular docking strategy

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37003 - e37003

Published: Aug. 28, 2024

The objective of this study was to investigate the potential carcinogenic toxicity and mechanisms PFAS in thyroid, renal, testicular cancers base on network toxicology molecular docking techniques. Structural modeling performed predict relevant information, compounds cancer-related targets were screened multiple databases. interaction with three their key protein explored by combining analysis, enrichment analysis PFOA, PFOS, PFHXS exhibited significant cytotoxic effects. These may induce cancer mediating active oxygen metabolism transduction phosphatidylinositol 3-kinase/protein kinase B signaling pathway through genes such as ALB, mTOR, MDM2, ERBB2. Furthermore, underlying toxic be linked pathways cancer, chemical carcinogenesis reactive species/receptor activation, FoxO pathway. results contribute a comprehensive understanding effects these environmental pollutants genes, proteins, metabolic living organisms. It revealed inducing cancers, provided solid theoretical foundation for designing new control strategies drug screening initiatives. Additionally, integrated application technology can enhance our unknown pollutants, which is beneficial protecting environment human health.

Language: Английский

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Adverse outcome pathway for the neurotoxicity of per- and polyfluoroalkyl substances: A systematic review

Eco-Environment & Health, Journal Year: 2024, Volume and Issue: 3(4), P. 476 - 493

Published: Aug. 30, 2024

Per- and polyfluoroalkyl substances (PFAS) are endocrine disruptors with unambiguous neurotoxic effects. However, due to variability in experimental models, population characteristics, molecular endpoints, the elucidation of mechanisms underlying PFAS-induced neurotoxicity remains incomplete. In this review, we utilized adverse outcome pathway (AOP) framework, a comprehensive tool for evaluating toxicity across multiple biological levels (molecular, cellular, tissue organ, individual, population), elucidate induced by PFAS. Based on 271 studies, reactive oxygen species (ROS) generation emerged as initiating event 1 (MIE1). Subsequent key events (KEs) at cellular level include oxidative stress, neuroinflammation, apoptosis, altered Ca

Language: Английский

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Exposure to PFOS, PFBS, PFOA and PFBA impairs cell cycle progression in bovine brain (Bos taurus) endothelial cells

Research in Veterinary Science, Journal Year: 2025, Volume and Issue: 187, P. 105585 - 105585

Published: Feb. 26, 2025

Language: Английский

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Biodegradation of per- and polyfluoroalkyl substances: microbes, enzymes and their interactions

Reviews in Environmental Science and Bio/Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Language: Английский

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Paternal and Maternal Exposures to Per- and Polyfluoroalkyl Substances and Child Behavioral Difficulties: A Parental Comparison Study

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Per- and polyfluoroalkyl substances (PFAS) are widespread environmental pollutants with documented developmental toxicity. Prior research of prenatal PFAS exposure offspring neurodevelopment did not consider the possible influence from paternal exposure. Using INUENDO cohort, we studied 334 father-mother-singleton triads enrolled antenatal clinics in Greenland, Poland, Ukraine. We measured five parental serum samples collected around 31 weeks gestation. assessed child behavioral difficulties at ages 5-9 years by parent-rated Strength Difficulties Questionnaire using country- sex-specific cut-offs (≥90th percentile). performed analyses stratified child's sex, coadjusting for maternal or other confounders estimating mixture effects quantile g-computation. In male children, multiple PFAS, modeled as individual chemicals a mixture, were associated externalizing difficulties. Maternal perfluorononanoic acid (PFNA) was internalizing female children. contrast, to children either sex. summary, but mid-childhood manner. Comparing parent-specific associations strengthened evidence against confounding shared family.

Language: Английский

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The Epididymis as a Target for Toxicants

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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