Tebuconazole Induces Mouse Fetal Testes Damage via ROS Generation in an Organ Culture Method DOI Open Access

Won-Young Lee,

Ran Lee, Hyun-Jung Park

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7050 - 7050

Published: June 27, 2024

The fungicide tebuconazole (TEB) poses risks to human and animal health via various exposure routes. It induces toxicity in multiple organs disrupts reproductive by affecting steroid hormone synthesis fetal development. In this study, we investigated the impact of TEB on testes using vitro models, focusing germ, Sertoli, Leydig cells, explored mechanisms underlying cellular damage. results revealed significant damage germ cells disruption cell led a decrease numbers, as indicated histological immunostaining analyses. induced up- down-regulation expression adult markers, respectively. Additionally, TEB-treated exhibited increased oxidative-stress-related genes proteins. However, co-treatment with antioxidant N-acetylcysteine mitigated TEB-induced prevented abnormal These findings suggest that administration antioxidants can prevent intratesticular typically caused exposure.

Language: Английский

Association of pesticide exposure with respiratory health outcomes and rhinitis in avocado farmworkers from Michoacán, Mexico DOI Creative Commons

Cecilia Alcalá,

Cynthia Armendáriz-Arnez, Ana M. Mora

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 945, P. 173855 - 173855

Published: June 12, 2024

A growing literature suggests associations between occupational pesticide exposure and respiratory health. In this study, we aimed to examine the association of insecticides, fungicides, herbicides, individually as a mixture, with health outcomes rhinitis in avocado farmworkers from Michoacán, Mexico.

Language: Английский

Citations

4

Characterizing avocado production systems for Ugandan exports: the need for consolidation and support for sustainable development DOI Creative Commons
Peter Sseruwagi,

Edouard Lehmann,

Paul Sigombe

et al.

Frontiers in Sustainable Food Systems, Journal Year: 2025, Volume and Issue: 9

Published: Feb. 12, 2025

Hass avocado production and trade are rapidly expanding globally, with increasing consumer demands on quality, safety sustainability. Last decade, the contribution of East Africa has increased tremendously following several comparative advantages. However, despite substantial recent public private investments, Uganda’s export lags behind neighboring countries. This is mainly due to sector’s limited organization, resulting in a fragmented market varying socio-economic, environmental, agronomic conditions. Consequently, data insights these variable systems negatively impact effectiveness interventions investments sector. In this study, producers were randomly selected across Uganda. Field visits included farm field surveys, GPS mapping areas, soil sampling for wet-chemistry analysis. Descriptive statistics, multivariate logistic regression, ANOVA used assess characteristics practices access advisory services certification. Farming dynamics characterized by assessing demographics, economic data, marketing, farmer farming including nutrient management, irrigation, pest disease control, post-harvest management. Results show immature but sector Production mostly occurs small- medium-sized fields no or inputs (i.e., fertilisers, pesticides, irrigation), using manual labor (family hired) under mixed cropping systems, lacking critical infrastructure, knowledge, extension services, markets. contrast farmer’s belief that soils suitable fertile avocado, analyses indicate urgent need site specific management interventions. Implementation good seem related size, lesser extent influenced age, orchard agroecology, while membership organizations/associations currently bring benefits. study highlights advantages opportunities Uganda identifies priority challenges be tackled future targeting sustainable industry.

Language: Английский

Citations

0

Tebuconazole Induces Mouse Fetal Testes Damage via ROS Generation in an Organ Culture Method DOI Open Access

Won-Young Lee,

Ran Lee, Hyun-Jung Park

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7050 - 7050

Published: June 27, 2024

The fungicide tebuconazole (TEB) poses risks to human and animal health via various exposure routes. It induces toxicity in multiple organs disrupts reproductive by affecting steroid hormone synthesis fetal development. In this study, we investigated the impact of TEB on testes using vitro models, focusing germ, Sertoli, Leydig cells, explored mechanisms underlying cellular damage. results revealed significant damage germ cells disruption cell led a decrease numbers, as indicated histological immunostaining analyses. induced up- down-regulation expression adult markers, respectively. Additionally, TEB-treated exhibited increased oxidative-stress-related genes proteins. However, co-treatment with antioxidant N-acetylcysteine mitigated TEB-induced prevented abnormal These findings suggest that administration antioxidants can prevent intratesticular typically caused exposure.

Language: Английский

Citations

2