Rapid investigation of BA.4/BA.5 cases in France DOI Creative Commons

Alain-Claude Kouamen,

Helena Da Cruz,

Mohamed Hamidouche

et al.

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Oct. 10, 2022

We aimed to describe the characteristics of individuals infected by BA.4 or BA.5 in France comparison BA.1, and analyze factors associated with hospitalization among cases. A standardized questionnaire was used collect information on confirmed probable Omicron Hospitalization risk BA.4/BA.5 cases were analyzed using Poisson regression. Variables a p-value below 0.2 univariate analysis priori confounders included multivariable regression model. The median age 301 investigated 47 years 97% symptomatic. most common clinical signs asthenia/fatigue (75.7%), cough (58.3%), fever headache (52.1%) rhinorrhea (50.7%). Twelve hospitalized, 27.1% reported factors. No admissions intensive care no deaths reported. Vaccination status available for 292 cases, 20.9% unvaccinated, 1.4% had received one dose, 38.3% two doses 39.4% three doses. Cases presenting at least factor almost seventeen times more likely be hospitalized than those (aRR = 16.72 [95% CI2.59-326.86]). Despite longer duration differences symptoms their possible immune escape, sub-lineages globally showed severe presentation. presence disease significantly increased BA.5.

Language: Английский

Change in the Clinical Picture of Hospitalized Patients with COVID-19 between the Early and Late Period of Dominance of the Omicron SARS-CoV-2 Variant DOI Open Access
Robert Flisiak, Dorota Zarębska‐Michaluk, Krystyna Dobrowolska

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(17), P. 5572 - 5572

Published: Aug. 26, 2023

This study aimed to compare the clinical picture of COVID-19 in initial and later period Omicron dominance identify populations still at risk. A retrospective comparison data 965 patients hospitalized during early Omicron's (EO, January-June 2022) with 897 from a (LO, July 2022-April 2023) SARSTer database was performed. Patients LO, compared EO, were older, had better condition on admission, lower need for oxygen mechanical ventilation, less frequent lung involvement imaging, showed much faster improvement. Moreover, overall mortality EO 14%, higher than that LO-9%. Despite milder course disease, exceeding 15% similar both groups among involvement. The accumulation risk factors such as an age 60+, comorbidities, involvement, saturation <90% resulted constant 98% patients, 8% 30% rate LO period. Multiple logistic regression revealed odds death phase. infections caused by currently dominant subvariants, prophylaxis is necessary people over 60 years age, especially those case pneumonia respiratory failure.

Language: Английский

Citations

18
The Potential Role of Viral Persistence in the Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) DOI Creative Commons
Lorenzo Lupi, Adriana Vitiello,

Cristina Parolin

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(5), P. 388 - 388

Published: May 8, 2024

The infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated not only with the development of disease but also long-term symptoms or post-acute sequelae SARS-CoV-2 (PASC). Multiple lines evidence support that some viral antigens and RNA can persist for up to 15 months in multiple organs body, often after apparent clearance from upper system, possibly leading persistence symptoms. Activation immune system observed a prolonged time, providing indirect elements infection. In gastrointestinal tract, could stimulate shaping local microbiota potential systemic effects. All these interactions need be investigated, taking into account predisposing factors, multiplicity pathogenic mechanisms, stratifying populations vulnerable individuals, particularly women, children, immunocompromised where may present additional challenges.

Language: Английский

Citations

7
Trends in Cases, Hospitalizations, and Mortality Related to the Omicron BA.4/BA.5 Subvariants in South Africa DOI Creative Commons
Waasila Jassat, Salim S. Abdool Karim, Lovelyn Ozougwu

et al.

Clinical Infectious Diseases, Journal Year: 2022, Volume and Issue: 76(8), P. 1468 - 1475

Published: Nov. 28, 2022

In this study, we compared admission incidence risk and the of mortality in Omicron BA.4/BA.5 wave to previous waves.

Language: Английский

Citations

23
The humoral and cellular immune evasion of SARS-CoV-2 Omicron and sub-lineages DOI Creative Commons

Tiandan Xiang,

Junzhong Wang, Xin Zheng

et al.

Virologica Sinica, Journal Year: 2022, Volume and Issue: 37(6), P. 786 - 795

Published: Nov. 23, 2022

The recently discovered SARS-CoV-2 variant Omicron (B.1.1.529) has rapidly become a global public health issue. substantial mutations in the spike protein this new have raised concerns about its ability to escape from pre-existing immunity established by natural infection or vaccination. In review, we give summary of current knowledge concerning antibody evasion properties and subvariants (BA.2, BA.2.12.1, BA.4/5, BA.2.75) therapeutic monoclonal antibodies sera vaccine recipients convalescent patients. We also summarize whether vaccine-induced cellular (memory B cell T response) can recognize specifically. brief, variants demonstrated remarkable evasion, with even more striking seen BA.4 BA.5 sub-lineages. Luckily, third booster dose significantly increased neutralizing titers, response remains conserved provides second-line defense against Omicron.

Language: Английский

Citations

22
The Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Epidemic and Acute Myocardial Infarction: A Self-Controlled Case Series Study DOI
Jun Suzuki, Tomoki Mizuno,

Shota Takahashi

et al.

Journal of Infection and Chemotherapy, Journal Year: 2025, Volume and Issue: 31(4), P. 102666 - 102666

Published: Feb. 26, 2025

Language: Английский

Citations

0
The Epidemiological Features of the SARS-CoV-2 Omicron Subvariant BA.5 and Its Evasion of the Neutralizing Activity of Vaccination and Prior Infection DOI Creative Commons
Dandan Tian,

Wenjian Nie,

Yanhong Sun

et al.

Vaccines, Journal Year: 2022, Volume and Issue: 10(10), P. 1699 - 1699

Published: Oct. 11, 2022

From December 2021 to May 2022, the Omicron BA.1 and BA.2 subvariants successively became most dominant strains in many countries around world. Subsequently, have emerged, has been classified into five main lineages, including BA.1, BA.2, BA.3, BA.4, BA.5, some sublineages (BA.1.1, BA.2.12.1, BA.2.11, BA.2.75, BA.4.6, BA.5.1, BA.5.2). The recent emergence of several generated new concerns about further escape from immunity induced by prior infection vaccination creation COVID-19 waves globally. In particular, BA.5 (first found southern Africa, February 2022) displays a higher transmissibility than other is replacing previously circulating countries.

Language: Английский

Citations

17
Risk of severe outcomes among SARS-CoV-2 Omicron BA.4 and BA.5 cases compared to BA.2 cases in England DOI Open Access
Nurin Abdul Aziz, Sophie Nash, Asad Zaidi

et al.

Journal of Infection, Journal Year: 2023, Volume and Issue: 87(1), P. e8 - e11

Published: April 24, 2023

Language: Английский

Citations

9
Survival of Critically Ill COVID-19 Patients in Sweden During the First Two and a Half Years of the Pandemic* DOI Creative Commons
Ailiana Santosa, Jonatan Oras, Huiqi Li

et al.

Critical Care Medicine, Journal Year: 2024, Volume and Issue: 52(8), P. 1194 - 1205

Published: March 28, 2024

Some studies have examined survival trends among critically ill COVID-19 patients, but most were case reports, small cohorts, and had relatively short follow-up periods. We aimed to examine the trend patients during first two a half years of pandemic investigate potential predictors across different variants concern

Language: Английский

Citations

3
Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV-2 variants delta and omicron—results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP) DOI Creative Commons
Sina M. Hopff, Katharina S. Appel, Olga Miljukov

et al.

Infection, Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Abstract Purpose The influence of new SARS-CoV-2 variants on the post-COVID-19 condition (PCC) remains unanswered. Therefore, we examined prevalence and predictors PCC-related symptoms in patients infected with delta or omicron. Methods We compared prevalences risk factors acute three months after primary infection (3MFU) between delta- omicron-infected from Cross-Sectoral Platform German National Pandemic Cohort Network. Health-related quality life (HrQoL) was determined by EQ-5D-5L index score trend groups were calculated to describe changes HrQoL different time points. Results considered 758 for our analysis (delta: n = 341; omicron: 417). Compared omicron patients, had a similar PCC at 3MFU (p 0.354), whereby fatigue occurred most frequently (n 256, 34%). comparable lowest (0.75, 95% CI 0.73–0.78) disease onset. While (69%, 348) never showed declined HrQoL, it deteriorated substantially 37 (7%) phase which 27 Conclusion With quality-controlled data multicenter cohort, that is an equally common challenge least population. Developing over two thirds did not experience any restrictions their due 3MFU. Clinical Trail registration cohort registered ClinicalTrials.gov since February 24, 2021 (Identifier: NCT04768998).

Language: Английский

Citations

3
The disease severity of COVID-19 caused by Omicron variants: A brief review DOI Creative Commons

Kohei Uemura,

Takumi Kanata, Sachiko Ono

et al.

Annals of Clinical Epidemiology, Journal Year: 2023, Volume and Issue: 5(2), P. 31 - 36

Published: Jan. 1, 2023

The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in November 2021 and spread worldwide. This review summarizes the reported mortality morbidity rates disease (COVID-19) caused by variants. In 21 previous studies, patients infected with variants ranged from 0.01 to 13.1%, whereas that those was 0.08% 29.1%. proportions intensive care unit admissions mechanical ventilation were lower for than Future studies should clarify mechanisms transmissibility severity COVID-19

Language: Английский

Citations

8