Persistence of post-COVID symptoms in the general population two years after SARS-CoV-2 infection: A systematic review and meta-analysis

Journal of Infection, Journal Year: 2023, Volume and Issue: 88(2), P. 77 - 88

Published: Dec. 13, 2023

This meta-analysis investigated the prevalence of post-COVID symptoms two-years after SARS-CoV-2 infection.

Language: Английский

---

Long COVID or Post-COVID-19 Condition: Past, Present and Future Research Directions

Microorganisms, Journal Year: 2023, Volume and Issue: 11(12), P. 2959 - 2959

Published: Dec. 11, 2023

The presence of symptoms after an acute SARS-CoV-2 infection (long-COVID) has become a worldwide healthcare emergency but remains underestimated and undertreated due to lack recognition the condition knowledge underlying mechanisms. In fact, prevalence post-COVID ranges from 50% during first months up 20% two-years after. This perspective review aimed map existing literature on identify gaps in guide global effort toward improved understanding long-COVID suggest future research directions. There is plethora symptomatology that can be COVID-19; however, today, there no clear classification definition this condition, termed or post-COVID-19 condition. heterogeneity led groups/clusters patients, which could exhibit different risk factors Viral persistence, long-lasting inflammation, immune dysregulation, autoimmune reactions, reactivation latent infections, endothelial dysfunction alteration gut microbiota have been proposed as potential mechanisms explaining complexity long-COVID. such equation, viral biology (e.g., re-infections, variants), host genetics, epigenetics) external vaccination) should also considered. These various will discussed current directions suggested.

Language: Английский

---

Post-covid-19 conditions in adults: systematic review and meta-analysis of health outcomes in controlled studies

BMJ Medicine, Journal Year: 2024, Volume and Issue: 3(1), P. e000723 - e000723

Published: Jan. 1, 2024

To assess the impact of post-covid-19 conditions among adults.

Language: Английский

---

Presence of SARS-CoV-2 RNA in COVID-19 survivors with post-COVID symptoms: a systematic review of the literature

Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2024, Volume and Issue: 62(6), P. 1044 - 1052

Published: Feb. 17, 2024

Viral persistence is one of the main hypotheses explaining presence post-COVID symptoms. This systematic review investigated SARS-CoV-2 RNA in plasma, stool, urine, and nasal/oral swab samples individuals with symptomatology.

Language: Английский

---

Post-COVID-19 condition in prospective inpatient and outpatient cohorts

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 26, 2025

Viral persistence, immune dysregulation, hypocortisolism, and pulmonary tissue damage from acute infection are proposed as pathogenic mechanisms underlying post-COVID-19 condition (PCC). In this prospective observational study, we followed 62 COVID-19 inpatients 53 outpatients for 24 months after the infection. During period, assessed prolonged symptoms, lung function, a set of immunological markers proportion patient group was with computed tomography three post-infection. The prevalence PCC, by four medical specialists, decreased 51% at to 18% months. Risk factors included severity comorbidities obstructive sleep apnea or obesity. Patients PCC had higher serum levels anti-SARS-CoV-2 S1 N protein antibodies. whole group, spirometry results, orthostatic hypotension, soluble suppression tumorigenicity 2, interleukin 6 (IL-6), high-sensitivity C-reactive (hs-CRP), cortisol no association PCC. However, using symptom clusters, patients cognitive problems lower levels, while ongoing respiratory myalgic symptoms IL-6 hs-CRP. more extensive studies clustering needed validate these results.

Language: Английский

---

Who develops long COVID? Longitudinal pre-pandemic predictors of long COVID and symptom clusters in a representative Dutch population

International Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: 144, P. 107048 - 107048

Published: April 10, 2024

Prior studies show that long COVID has a heterogeneous presentation. Whether specific risk factors are related to subclusters of remains unknown. This study aimed determine pre-pandemic predictors and symptom clustering.

Language: Английский

---

Presence of SARS‐CoV‐2 RNA in COVID‐19 survivors with post‐COVID symptoms 2 years after hospitalization: The VIPER study

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(5)

Published: May 1, 2024

Abstract The SARS‐CoV‐2 VIrus PERsistence (VIPER) study investigated the presence of long‐lasting RNA in plasma, stool, urine, and nasopharyngeal samples COVID‐19 survivors. reverse transcription polymerase chain reactions (RT‐PCR) were analyzed within swab survivors with post‐COVID symptoms a comparison group without matched by age, sex, body mass index vaccination status. Participants self‐reported any symptom (defined as that started no later than 3 months after initial infection). Fifty‐seven (57.9% women, age: 51.1, standard deviation [SD]: 10.4 years) previously hospitalized 55 (56.4% 50.0, SD: 12.8 individuals who had past infection evaluated 27 (SD 7.5) 26 8.7) hospital discharge, respectively. was identified three patients (5.2%) but not or urine samples. Thus, sample symptoms. most prevalent consisted fatigue (93%), dyspnea, pain (both, 87.7%). This did find samples, 2 years infection. A prevalence 5.2% suggesting potential active recent reinfection, found These results do support association between symptomatology recruited population.

Language: Английский

---

Cluster analysis of long COVID symptoms for deciphering a syndrome and its long-term consequence

Immunologic Research, Journal Year: 2024, Volume and Issue: 72(4), P. 605 - 613

Published: April 16, 2024

Abstract The long-term symptoms of COVID-19 are the subject public and scientific discussions. Understanding how those long COVID co-occur in clusters syndromes may indicate pathogenic mechanisms COVID. Our study objective was to cluster different symptoms. We included persons who had a assessed (at least 4 weeks after first symptoms). Hierarchical clustering applied as well participants based on Euclidean distance h log-values answers symptom severity. distribution within our cohort is shown heat map. From September 2021 November 2023, 2371 with persisting participated study. Self-assessed were assigned three clusters. Cluster A unites rheumatological neurological symptoms, B includes neuro-psychological together cardiorespiratory third C shows an association general infection signs, dermatological otology high proportion ( n = 1424) showed all Clustering reveals similarities symptomatology already described such Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) or autoinflammatory diseases. Further research identify serological parameters clinical risk factors associated might improve understanding systemic disease. Furthermore, multimodal treatments can be developed scaled for impairments.

Language: Английский

---

Indoor environmental quality models: A bibliometric, mapping and clustering review

Renewable and Sustainable Energy Reviews, Journal Year: 2024, Volume and Issue: 203, P. 114791 - 114791

Published: July 30, 2024

Language: Английский

---

Improving Occupational Rehabilitation for People Living with Long COVID

Journal of Occupational Rehabilitation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

---