Brain Behavior & Immunity - Health, Journal Year: 2025, Volume and Issue: unknown, P. 100980 - 100980
Published: March 1, 2025
Language: Английский
Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2024, Volume and Issue: 62(6), P. 1044 - 1052
Published: Feb. 17, 2024
Viral persistence is one of the main hypotheses explaining presence post-COVID symptoms. This systematic review investigated SARS-CoV-2 RNA in plasma, stool, urine, and nasal/oral swab samples individuals with symptomatology.
Language: Английский
Citations
15
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 5, 2024
Objective The long-lasting persistence of autoantibodies stands as one the hypotheses explaining multisystemic manifestations seen in individuals with post-COVID-19 condition. current review offers restricted insights into plasma/serum people post-COVID symptoms. Methods PubMed/MEDLINE, CINAHL, EMBASE, and Web Science databases, well on medRxiv bioRxiv preprint servers were searched up to January 5 th , 2024. Papers investigating presence samples symptoms included. Newcastle-Ottawa Scale (NOS) was used assess methodological quality. Results From 162 identified records, five articles met all inclusion criteria; four studies included infected controls no whereas non-infected (410 COVID-19 survivors symptoms, 223 266 healthy controls). Four concluded that had a potential (but small) role condition study not associated. Quality assessment showed high Conclusion Although evidence suggests persistent can be associated clinical relevance their seems modest at this stage. Current results highlight further research clarify development guiding tailored diagnostic treatment approaches enhance patient outcomes. Systematic registration https://osf.io/vqz28 .
Language: Английский
Citations
10
Medicine, Journal Year: 2024, Volume and Issue: 103(12), P. e37502 - e37502
Published: March 22, 2024
The incidence of long COVID in adult survivors an acute SARS-CoV-2 infection is approximately 11%. Of those afflicted, 26% have difficulty with day-to-day activities. majority COIVD cases occur after mild or asymptomatic infection. Children can spread infections and also develop long-term neurological, endocrine (type I diabetes), immunological sequelae. Immunological hypofunction exemplified by the recent large outbreaks respiratory syncytial virus streptococcal infections. Neurological manifestations are associated anatomical brain damage demonstrated on scans autopsy studies. prefrontal cortex particularly susceptible. Common symptoms include fog, memory loss, executive dysfunction, personality changes. impact society has been profound. Fewer than half previously employed adults who working full-time, 42% patients reported food insecurity 20% difficulties paying rent. Vaccination not only helps prevent severe COVID-19, but numerous studies found beneficial effects preventing mitigating COVID. There evidence that vaccination lessen Physical occupational therapy help regain function, approach must be "low slow." Too much physical mental activity result post-exertional malaise set back recovery process days weeks. complexity presentations coupled rampant organized disinformation, caused significant segments public to ignore sound health advice. Further research needed regarding treatment effective communication.
Language: Английский
Citations
8
Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 6, 2025
Post COVID-19 condition (PCC) is increasingly recognized as a debilitating characterized by persistent symptoms following SARS-CoV-2 infection. Neuropsychological deficits, including cognitive impairments and fatigue, are prevalent in individuals with PCC. The PoCoRe study aimed to evaluate the burden of neuropsychological deficits PCC patients undergoing multidisciplinary indoor rehabilitation describe possible changes this symptomatology. study, prospective, non-randomized, controlled longitudinal recruited from six German centers. Eligible participants underwent comprehensive assessments at admission discharge. Various measures were employed, fatigue scale for motor functioning cognition (FSMC), Test Battery Attention (TAP) Montreal Cognitive Assessment (MoCA). Out 1,086 participants, total N = 701 included main data analysis. prevalence on was high (84.6%) decreased significantly discharge (77.4%), mild effect size. Reaction times alertness subtest abnormal 70% 50% Sustained attention 55% admission, decreasing 43% These differences significant sizes. Furthermore, 27% pathological MoCA scores 63% improved normative levels during rehabilitation, indicating treatment (p ≤ 0.001). However, demonstrated limited sensitivity detecting deficits. highlights patients, notable improvements observed rehabilitation. Challenges remain accurately identifying addressing these underscoring importance assessment tailored interventions. Further research warranted optimize screening tools enhance care both outpatient settings.
Language: Английский
Citations
1
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0315815 - e0315815
Published: March 3, 2025
The long-term health consequences following COVID-19 have largely been reported in adult populations living high-income countries. We therefore did a systematic review of post condition symptoms children and adolescents (<18 years), aiming to identify include publications from low- or middle-income countries (LMICs). From EMBASE, Medline, Pubmed until the 30th October 2023, we searched all studies reporting original complete data outcomes at least 20 under 18 years age with history confirmed acute infection. excluded non-English publications, pre-prints, unreviewed articles, grey literature, inaccessible full text, those limited specific population. Risk Bias was assessed using STROBE guidelines for observational studies. used descriptive narrative analysis summarize findings. Forty 825,849 adolescents; median persistent consistently adolescent range but not included young (<5 years). Only one study, 58 participants aged 6-17 years, population LMIC. Studies relied on symptom rather than objective measures organ dysfunction. definition varied; most duration two three months more. However, since onset specified, it difficult which study is truly consistent WHO's condition. Prevalence ranged 1.8% 70% marked heterogeneity between criteria including severity COVID presentation. Most were undertaken when Alpha variant predominant strain. prevalence 6.7% variant-, 23% 61.9% Delta-, 17% 34.6% Omicron-, 3.7% 34% Other-variant predominated fatigue (70%), headache (37.5%) respiratory (35%); subgroups. half control group. variations population, methods, reliance alone lack groups make challenging determine impact adolescents. LMIC especially infants major gap.
Language: Английский
Citations
1
EClinicalMedicine, Journal Year: 2024, Volume and Issue: 76, P. 102815 - 102815
Published: Sept. 5, 2024
Language: Английский
Citations
7
Journal of Infection, Journal Year: 2024, Volume and Issue: unknown, P. 106297 - 106297
Published: Sept. 1, 2024
Language: Английский
Citations
7
Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: 30(12), P. 1505 - 1513
Published: July 14, 2024
Language: Английский
Citations
6
Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(5)
Published: May 1, 2024
Abstract The SARS‐CoV‐2 VIrus PERsistence (VIPER) study investigated the presence of long‐lasting RNA in plasma, stool, urine, and nasopharyngeal samples COVID‐19 survivors. reverse transcription polymerase chain reactions (RT‐PCR) were analyzed within swab survivors with post‐COVID symptoms a comparison group without matched by age, sex, body mass index vaccination status. Participants self‐reported any symptom (defined as that started no later than 3 months after initial infection). Fifty‐seven (57.9% women, age: 51.1, standard deviation [SD]: 10.4 years) previously hospitalized 55 (56.4% 50.0, SD: 12.8 individuals who had past infection evaluated 27 (SD 7.5) 26 8.7) hospital discharge, respectively. was identified three patients (5.2%) but not or urine samples. Thus, sample symptoms. most prevalent consisted fatigue (93%), dyspnea, pain (both, 87.7%). This did find samples, 2 years infection. A prevalence 5.2% suggesting potential active recent reinfection, found These results do support association between symptomatology recruited population.
Language: Английский
Citations
4
Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e41987 - e41987
Published: Jan. 20, 2025
Post-COVID-19 condition (Long COVID) refers to a in which patients endure persistent symptoms for more than 12 weeks, typically occurring at least 3 months after the onset of Coronavirus disease 2019 (COVID-19) infection. It occurs when constellation persists following initial illness, and this may obstruct daily routine impose difficulty life. Therefore, study aimed systematically review published articles assessing neurocognitive profile long COVID patients, with specific emphasis on executive function (EF), determine correlation between EF deficits brain alterations through utilisation neuroimaging modalities. A thorough search was conducted using PubMed/MEDLINE Web Science online databases PICOS PRISMA 2020 guidelines. All included studies were deemed be high quality according Newcastle-Ottawa Scale (NOS). total 31 out 3268 present study. The main outcome is proportion individuals cognitive deficits, particularly domain, as detected by neuropsychological assessments. also revealed that are correlated disruptions frontal cerebellar regions, affecting processes such nonverbal reasoning, aspects language, recall. This consistent disturbance emphasised COVID. highlights importance evaluating patients. insight has potential improve future treatments interventions.
Language: Английский
Citations
0