Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: March 1, 2024

The extracellular matrix (ECM) is a highly complex structure through which biochemical and mechanical signals are transmitted. In processes of cell migration, the ECM also acts as scaffold, providing structural support to cells well points potential attachment. Although well-studied structure, its role in many biological remains difficult investigate comprehensively due complexity variation within an organism. tandem with experiments, mathematical models helpful refining testing hypotheses, generating predictions, exploring conditions outside scope experiments. Such can be combined calibrated vivo vitro data identify critical cell-ECM interactions that drive developmental homeostatic processes, or progression diseases. this review, we focus on computational such migration including cancer metastasis, tissue morphogenesis. By highlighting predictive power these models, aim help bridge gap between experimental approaches studying provide guidance selecting appropriate model framework complement corresponding studies.

Language: Английский

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A review on the biomechanical behaviour of the aorta

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2023, Volume and Issue: 144, P. 105922 - 105922

Published: June 1, 2023

Large aortic aneurysm and acute chronic dissection are pathologies of the aorta requiring surgery. Recent advances in medical intervention have improved patient outcomes; however, a clear understanding mechanisms leading to failure and, hence, better risk, is still missing. Biomechanical analysis could provide insights into development progression abnormalities, giving clinicians powerful tool risk stratification. The complexity system presents significant challenges for biomechanical study requires various approaches analyse aorta. To address this, here we present holistic review studies by categorising articles four broad approaches, namely theoretical, vivo, experimental combined investigations. Experimental that focus on identifying mechanical properties tissue also included. By reviewing literature discussing drawbacks, limitations future each area, hope more complete picture state-of-the-art biomechanics stimulate research critical topics. Combining modalities computational lead comprehensive results prediction system.

Language: Английский

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Non-Linear Hyperelastic Model Analysis and Numerical Validation of 3D Printed PLA+ Material Incorporating Various Infill Densities

Machines, Journal Year: 2025, Volume and Issue: 13(2), P. 91 - 91

Published: Jan. 24, 2025

Additive manufacturing (AM) or 3D printing technology creates a tangible object by adding successive layers of materials. Nowadays, is used for developing both metal and non-metal products. In the advancement technology, material specimen design, modification, testing become very simple, especially materials, such as hyperelastic, thermoplastic, rubber-like However, proper modeling validation are required analysis these types this study, printed poly lactic acid (PLA+) behavior analyzed numerically in counterpart experimental to evaluate their cases. The was designed SolidWorks following ASTM D638 dimension standards with infill densities raster angle orientation angle. These layer angles play an important role mechanical specimen. This paper aims present numerical five (20%, 40%, 60%, 80%, 100%) ±45-degree incorporating nonlinear hyperelastic model. Results indicate that affect PLA+ material. result also suggested neo-Hookean Mooney–Rivlin best-fitted models separate linear densities. easier analyze, it has only one parameter new equation developed study determining different

Language: Английский

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Highly nonlinear hyperelastic shells: Statics and dynamics

International Journal of Engineering Science, Journal Year: 2022, Volume and Issue: 183, P. 103794 - 103794

Published: Dec. 2, 2022

Language: Английский

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Nonlinear dynamical model of hyperelastic pipes conveying fluid with finite deformation: roles of hyperelasticity and nonlinearity

Nonlinear Dynamics, Journal Year: 2023, Volume and Issue: 111(15), P. 13691 - 13708

Published: June 3, 2023

Language: Английский

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2D and 3D PVA electrospun scaffold evaluation for ligament implant replacement: A mechanical testing, modelling and experimental biomechanics approach

Materialia, Journal Year: 2024, Volume and Issue: 33, P. 102042 - 102042

Published: Feb. 24, 2024

Language: Английский

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Suppression of cross-well vibrations of a bistable square cross-ply laminate using an additional composite strip

International Journal of Dynamics and Control, Journal Year: 2023, Volume and Issue: 11(6), P. 2680 - 2690

Published: March 27, 2023

Language: Английский

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Large deformation of hyperelastic modified Timoshenko–Ehrenfest beams under different types of loads

Computer Methods in Applied Mechanics and Engineering, Journal Year: 2023, Volume and Issue: 416, P. 116368 - 116368

Published: Sept. 7, 2023

Language: Английский

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Methodological Aspects and Mesh Convergence in Numerical Analysis of Athermal Fiber Network Material Deformation

Fibers, Journal Year: 2024, Volume and Issue: 12(1), P. 9 - 9

Published: Jan. 12, 2024

A balance between model complexity, accuracy, and computational cost is a central concern in numerical simulations. In particular, for stochastic fiber networks, the non-affine deformation of fibers, related non-linear geometric features due to large global deformation, size effects can significantly affect accuracy computer experiment outputs increase cost. this work, we systematically investigate methodological aspects network simulations with focus on output models cellular (Voronoi) fibrous (Mikado) architecture. We study both p h-refinement discretizations finite element solution procedure, uniform length-based adaptive strategies. The analysis conducted linear elastic viscoelastic constitutive behavior as well networks initially straight crimped fibers. With relative error determining criterion, provide recommendations mesh refinement, comment necessity multiple realizations, give an overview associated that will serve guidance toward minimizing while maintaining desired level accuracy.

Language: Английский

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Thermomechanical properties of metal–organic framework HKUST-1 crystals

Journal of Materials Chemistry A, Journal Year: 2024, Volume and Issue: 12(25), P. 15071 - 15081

Published: Jan. 1, 2024

Based on the in situ compression tests at elevated temperatures, very different mechanical behaviours are observed HKUST-1 crystals temperatures.

Language: Английский

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