ACS Sustainable Chemistry & Engineering,
Journal Year:
2023,
Volume and Issue:
11(47), P. 16828 - 16839
Published: Nov. 10, 2023
Deep
eutectic
solvents
have
emerged
as
promising
alternatives
to
traditional
lubricants
due
their
ease
of
preparation,
low
cost,
low/no
pollution,
reproducibility,
and
unique
antifriction
antiwear
performance.
Herein,
green
sorbitol-based
deep
are
successfully
synthesized
using
d-sorbitol
quaternary
ammonium
salts
hydrogen
bond
donors
acceptors,
respectively,
through
a
simple
heating
stirring
method.
The
exhibit
good
thermostability,
high
viscosity,
favorable
wettability
on
the
steel
surface.
Notably,
tribological
tests
demonstrated
that
displayed
outstanding
friction-reducing
properties
were
observed
achieve
nearly
wearless
behavior
surface
under
contact
pressure
(2.16
GPa).
X-ray
photoelectron
spectroscopy,
scanning
electron
microscopy,
high-resolution
transmission
microscopy
revealed
complex
tribofilms
formed
because
tribochemical
reactions
physical
adsorption
substrates,
resulting
in
properties.
These
results
demonstrate
as-synthesized
candidates
for
sustainable
lubricating
materials
with
eminent
Furthermore,
present
work
may
provide
guidance
reference
development
high-performance
solvent-based
materials.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(1), P. 124 - 124
Published: Jan. 18, 2024
The
extraction
of
bioactive
compounds
pharmaceutical
interest
from
natural
sources
has
been
significantly
explored
in
recent
decades.
However,
the
techniques
used
were
not
very
efficient
terms
time
and
energy
consumption;
additionally,
solvents
for
harmful
environment.
To
improve
environmental
impact
extractions
at
same
increase
yields,
several
new
developed.
Among
most
ones
are
ultrasound-assisted
microwave-assisted
extraction.
These
increased
yield
selectivity
a
smaller
amount
with
decrease
consumption.
Nevertheless,
high
volume
organic
was
still
extraction,
causing
subsequent
problem.
Neoteric
appeared
as
green
alternatives
to
solvents.
neoteric
solvents,
deep
eutectic
evidenced
be
one
best
due
their
intrinsic
characteristics.
considered
because
they
made
up
such
sugars,
amino
acids,
carboxylic
acids
having
low
toxicity
degradability.
In
addition,
simple
prepare,
an
atomic
economy
100%,
attractive
physicochemical
properties.
Furthermore,
huge
number
that
can
synthesize
these
make
them
useful
since
tailored
selective
towards
specific
component
or
class
components.
main
aim
this
paper
is
give
comprehensive
review
which
describes
properties,
characteristics,
production
methods
well
its
application
extract
interest.
Additionally,
overview
more
sustainable
also
given.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(3), P. 357 - 389
Published: Jan. 1, 2024
Abstract
The
pharmaceutical
industry
has
traditionally
employed
batch
processing
as
a
means
of
synthesizing
active
ingredients
(APIs)
on
commercial
scale.
Batch
manufacturing
enables
API
synthesis
in
large
quantities
order
to
meet
regulations.
Yet,
this
strategy
remains
cumbersome,
is
labor‐intensive,
and
creates
complex
logistical
networks.
In
recent
decades,
gradually
eroded
American
economic
competitiveness
led
the
offshoring
from
United
States.
Today
it
estimated
that
+80%
APIs
are
manufactured
overseas.
[1]
Meanwhile,
disruptions
Coronavirus
Disease
(SARS‐CoV‐2)
have
exacerbated
weaknesses
global
supply
chain,
culminating
with
widespread
shortages
critical
life‐saving
drugs.
[2]
These
emphasized
importance
reshoring
drug
U.S.
fostered
regulatory
landscape
seeks
advanced
methods
bolster
America's
chain
resiliency.
[3]
Recently,
increased
attention
been
directed
towards
continuous
enable
nonstop
production
within
modular
stand‐alone
flow
systems.
Continuous
(CM)
facilitates
automation,
offers
new
avenues
process
intensification,
even
in‐line
analytical
monitoring
raw
materials
packaged
products.
This
better
conversion,
safety,
reduced
waste,
overall
cost
savings
versus
traditional
batch‐style
processing.
rise
manufacturing,
coupled
current
landscape,
rare
window
opportunity
convert
processes
into
continuous,
streamlined
systems
on‐shore
eliminate
shortages.
review
will
outline
state‐of‐the‐art
CM
highlight
translation
chemistry
unit
operations
Molecules,
Journal Year:
2024,
Volume and Issue:
29(10), P. 2296 - 2296
Published: May 14, 2024
Deep
eutectic
solvents
(DESs)
are
commonly
used
in
pharmaceutical
applications
as
excellent
solubilizers
of
active
substances.
This
study
investigated
the
tuning
ibuprofen
and
ketoprofen
solubility
utilizing
DESs
containing
choline
chloride
or
betaine
hydrogen
bond
acceptors
various
polyols
(ethylene
glycol,
diethylene
triethylene
glycerol,
1,2-propanediol,
1,3-butanediol)
donors.
Experimental
data
were
collected
for
all
DES
systems.
A
machine
learning
model
was
developed
using
COSMO-RS
molecular
descriptors
to
predict
solubility.
All
studied
exhibited
a
cosolvency
effect,
increasing
drug
at
modest
concentrations
water.
The
accurately
predicted
ibuprofen,
ketoprofen,
related
analogs
(flurbiprofen,
felbinac,
phenylacetic
acid,
diphenylacetic
acid).
approach
enables
rational
design
prediction
formulations
improved
applications.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4683 - 4716
Published: Sept. 2, 2024
About
40%
of
approved
drugs
and
nearly
90%
drug
candidates
are
poorly
water-soluble
drugs.
Low
solubility
reduces
the
drugability.
Effectively
improving
bioavailability
is
a
critical
issue
that
needs
to
be
urgently
addressed
in
development
application.
This
review
briefly
introduces
conventional
solubilization
techniques
such
as
solubilizers,
hydrotropes,
cosolvents,
prodrugs,
salt
modification,
micronization,
cyclodextrin
inclusion,
solid
dispersions,
details
crystallization
strategies,
ionic
liquids,
polymer-based,
lipid-based,
inorganic-based
carriers
bioavailability.
Some
most
commonly
used
carrier
materials
for
presented.
Several
using
summarized.
Furthermore,
this
summarizes
mechanism
each
technique,
reviews
latest
research
advances
challenges,
evaluates
potential
clinical
translation.
could
guide
selection
approach,
dosage
form,
administration
route
Moreover,
we
discuss
several
promising
attracting
increasing
attention
worldwide.
