ACS Sustainable Chemistry & Engineering,
Journal Year:
2023,
Volume and Issue:
11(47), P. 16828 - 16839
Published: Nov. 10, 2023
Deep
eutectic
solvents
have
emerged
as
promising
alternatives
to
traditional
lubricants
due
their
ease
of
preparation,
low
cost,
low/no
pollution,
reproducibility,
and
unique
antifriction
antiwear
performance.
Herein,
green
sorbitol-based
deep
are
successfully
synthesized
using
d-sorbitol
quaternary
ammonium
salts
hydrogen
bond
donors
acceptors,
respectively,
through
a
simple
heating
stirring
method.
The
exhibit
good
thermostability,
high
viscosity,
favorable
wettability
on
the
steel
surface.
Notably,
tribological
tests
demonstrated
that
displayed
outstanding
friction-reducing
properties
were
observed
achieve
nearly
wearless
behavior
surface
under
contact
pressure
(2.16
GPa).
X-ray
photoelectron
spectroscopy,
scanning
electron
microscopy,
high-resolution
transmission
microscopy
revealed
complex
tribofilms
formed
because
tribochemical
reactions
physical
adsorption
substrates,
resulting
in
properties.
These
results
demonstrate
as-synthesized
candidates
for
sustainable
lubricating
materials
with
eminent
Furthermore,
present
work
may
provide
guidance
reference
development
high-performance
solvent-based
materials.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(10), P. 2015 - 2015
Published: Sept. 22, 2022
Highly
hygroscopic
pharmaceutical
and
nutraceutical
solids
are
prone
to
significant
changes
in
their
physicochemical
properties
due
chemical
degradation
and/or
solid-state
transition,
resulting
adverse
effects
on
therapeutic
performances
shelf
life.
Moisture
absorption
also
leads
excessive
wetting
of
the
solids,
causing
difficult
handling
during
manufacturing.
In
this
review,
four
formulation
strategies
that
have
been
employed
tackle
hygroscopicity
issues
oral
solid
dosage
forms
pharmaceuticals/nutraceuticals
were
discussed.
The
(1)
film
coating,
(2)
encapsulation
by
spray
drying
or
coacervation,
(3)
co-processing
with
excipients,
(4)
crystal
engineering
co-crystallization.
Film
coating
work
acting
as
barriers
between
active
ingredients
core
environment,
whereas
excipients
works
mainly
adding
deflect
moisture
away
from
ingredients.
Co-crystallization
altering
packing
arrangements
introducing
stabilizing
co-formers.
For
pharmaceuticals,
co-crystallization
most
commonly
strategies,
popular
for
nutraceuticals
(e.g.,
medicinal
herbs,
protein
hydrolysates).
Encapsulation
is
rarely
applied
just
used
nutraceuticals.
Therefore,
there
potential
improved
reduction
exploring
beyond
traditionally
strategy.
International Journal of Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
634, P. 122696 - 122696
Published: Feb. 8, 2023
Recently,
Natural
Deep
Eutectic
Solvents
(NaDES)
have
emerged
as
potential
solvents
for
boosting
drug
bioavailability.
In
this
work,
the
mechanism
of
solubility
enhancement
some
APIs
belonging
to
BCS
class
II
(tolbutamide,
nimesulide,
domperidone
and
cinnarizine)
in
these
eutectic
bio-solvents
was
investigated
order
get
deeper
insights
into
molecular
interactions
between
NaDES
components
selected
drugs.
Different
formulations
based
on
choline
chloride,
proline,
solid
organic
acids
(citric,
tartaric
malic
acid),
sugars
(glucose
xylitol)
water
were
prepared
by
mild
heating
(70
°C).
Characterization
unloaded
(pH,
Karl
Fisher
titration,
viscosity
FTIR
analysis)
indicated
that
type
Hydrogen
Bond
Acceptor
(HBA)
Donor
(HBD),
their
molar
ratio
well
amount
strongly
affect
extent
H-bonding
interactions.
Hard
gelatin
capsules
filled
with
maintained
integrity
until
6
months,
proving
all
molecules
participate
H-bond
network.
APIs'
significant
respect
buffer
solutions
(pH
1.2
6.8).
Analysing
having
Choline
HBA,
it
found
smaller
increased
using
larger
HBD,
while
higher
weight
can
be
better
inserted
network
formed
HBD.
NOE
experiments
demonstrated
formation
a
robust
supramolecular
structure
among
protons
choline,
those
acid
water.
addition,
1D
ROESY
spectra
revealed
first
time
crucial
role
(methyl
groups)
establishing
hydrophobic
relative
aliphatic
or
aromatic
portion
These
data
suggest
complex
API-NaDES
assembly
underline
is
dependent
balance
H-bonds
well.
Understanding
API
essential
use
effective
solubilisation
aid.
International Journal of Food Science & Technology,
Journal Year:
2023,
Volume and Issue:
58(12), P. 6660 - 6673
Published: Aug. 17, 2023
Summary
A
review
paper
on
the
natural
deep
eutectic
solvents
(NaDES)
application
to
extraction
of
bioactives
from
products
and
agri‐food
wastes
is
introduced.
NaDES
are
mixtures
two
or
more
compounds
forming
a
liquid
phase
at
room
temperature
based
in
hydrogen
bond
acceptors
(quaternary
amines,
alcohols)
donors
(sugars,
organic
acids).
NADES
have
unique
properties
such
as
low
toxicity,
biodegradability
high
solubility
for
wide
range
compounds.
They
represent
sustainable
alternative
traditional
variety
applications,
particularly
metabolites
extraction.
Therefore,
status
displayed
terms
their
inspiration
nature,
preparation
physicochemical
properties,
well
conditions
biologically
important
phytochemicals
alkaloids,
carotenoids,
phenolics
(anthocyanins,
isoflavonoids,
curcuminoids).
Remarks
emerging
technologies
therapeutic,
hydrophilic,
hydrophobic
systems
inserted.
As
can
be
easily
prepared
renewable
sources,
they
promising
green
food,
nutraceutical,
pharmaceutical
industries.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2023,
Volume and Issue:
11(47), P. 16828 - 16839
Published: Nov. 10, 2023
Deep
eutectic
solvents
have
emerged
as
promising
alternatives
to
traditional
lubricants
due
their
ease
of
preparation,
low
cost,
low/no
pollution,
reproducibility,
and
unique
antifriction
antiwear
performance.
Herein,
green
sorbitol-based
deep
are
successfully
synthesized
using
d-sorbitol
quaternary
ammonium
salts
hydrogen
bond
donors
acceptors,
respectively,
through
a
simple
heating
stirring
method.
The
exhibit
good
thermostability,
high
viscosity,
favorable
wettability
on
the
steel
surface.
Notably,
tribological
tests
demonstrated
that
displayed
outstanding
friction-reducing
properties
were
observed
achieve
nearly
wearless
behavior
surface
under
contact
pressure
(2.16
GPa).
X-ray
photoelectron
spectroscopy,
scanning
electron
microscopy,
high-resolution
transmission
microscopy
revealed
complex
tribofilms
formed
because
tribochemical
reactions
physical
adsorption
substrates,
resulting
in
properties.
These
results
demonstrate
as-synthesized
candidates
for
sustainable
lubricating
materials
with
eminent
Furthermore,
present
work
may
provide
guidance
reference
development
high-performance
solvent-based
materials.
