The
number
of
people
affected
by
eye
conditions
is
growing
every
year,
due
to
the
popularity
electronic
devices
and
an
aging
population.
In
world
medicine,
accomplishing
medication
administration
has
always
been
a
difficult
task.
Despite
fact
that
there
are
many
drops
on
market,
most
them
have
important
limitations
quick
clearance
mechanisms
ocular
barriers.
One
solution
with
tremendous
potential
contact
lens
used
as
delivery
vehicle
bypass
this
constraint.
Therapeutic
lenses
for
attracted
lot
attention
because
they
improve
bioavailability,
patient
compliance,
reduce
side
effects.
However,
it
essential
not
compromise
features
such
water
content,
optical
transparency,
modulus
in
order
target
successful
vitro
vivo
sustained
drug
profile
from
impregnated
lenses.
Aside
difficulties
like
stability
burst
release,
changing
physical
chemical
properties
caused
therapeutic
or
non-therapeutic
components
can
limit
commercialization
pharmaceutical-loaded
Research
progressed
towards
bioinspired
techniques
smart
materials
efficacy
drug-eluting
method
uses
polymeric
biocompatibility,
specialized
molecule
recognition
technique
called
molecular
imprinting,
stimuli-responsive
system
biocompatibility
support
This
review
encompasses
strategies
material
design,
manufacturing
impregnation
under
current
auspices
ophthalmic
therapies
projects
outlook
onto
future
opportunities
field
management
means
active
principles-eluting
lens.
Japanese Journal of Ophthalmology,
Journal Year:
2024,
Volume and Issue:
68(5), P. 594 - 602
Published: May 25, 2024
To
reveal
the
penetration
of
epinastine,
an
anti-allergic
ophthalmic
agent,
into
eyelid
and
its
distribution
to
conjunctiva
after
administration
a
cream
formulation
on
rabbit
skin.
Eye,
Journal Year:
2023,
Volume and Issue:
38(5), P. 829 - 840
Published: Nov. 13, 2023
Abstract
Climate
change
is
a
threat
to
human
health
and
wellbeing
across
the
world.
In
recent
years,
there
has
been
surge
in
awareness
of
this
crisis,
leading
many
countries
organisations
setting
“net-zero”
targets.
This
entails
minimising
carbon
emissions
neutralising
remaining
by
removing
from
atmosphere.
At
2022
United
Nations
Change
Conference
(COP27),
commitments
transition
away
fossil
fuels
augment
climate
targets
were
underwhelming.
It
therefore
imperative
for
public
private
sector
demonstrate
successful
implementation
net-zero
set
precedent
global
political
consensus.
As
top
10
world
employer,
Kingdom
National
Health
Service
(NHS)
pledged
reach
2045.
The
NHS
already
taken
positive
steps
forward,
but
its
scale
complexity
as
system
means
stakeholders
each
services
must
highlight
specifications
further
progress.
Dry
eye
disease
chronic
illness
with
an
estimated
prevalence
29.5%
environmentally
damaging
care
pathway.
Moreover,
environmental
damage
known
aggravator
dry
disease.
Worldwide
management
generates
copious
amounts
non-recyclable
waste,
utilises
inefficient
supply
chains
involves
recurrent
follow-up
appointments
prescriptions.
By
mapping
pathway
impact,
review
we
will
seven
key
areas
which
reduced
pollution
could
be
targeted.
Examining
these
approaches
improved
sustainability
critical
driving
transformation
needed
preserve
our
wellbeing.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(6), P. e16916 - e16916
Published: June 1, 2023
Soft
contact
lenses
are
increasingly
being
explored
as
a
vehicle
for
controlled
delivery
of
ophthalmic
drugs.
However,
traditional
methods
drug-loading
by
soaking
have
limitations
such
burst
and
the
release
drugs
at
front
side
lens,
leading
to
poor
drug
efficacy
systemic
effects.
This
study
introduces
new
methodology,
termed
asymmetric
loading,
whereby
'Rebamipide'
is
attached
released
from
post-lens
(=cornea-contacting)
surface
exclusively.
The
methodology
involves
using
polymeric
microparticles
that
carry
lipophilic
crystalline
their
surface.
These
drug-loaded
first
transfer
concave
when
worn,
transferred
again,
now
lens
cornea.
achieved
through
diffusion
one
hydrophobic
microenvironment
(the
silicone
moieties
polymer
network)
another
corneal
epithelium)
over
short
pathway.
second
was
observed
studied
in
experiments
an
ex
vivo
porcine
eye
model.
results
show
amount
absorbed
cornea
after
applying
rebamipide-loaded
approximately
3×
(10.7
±
3.1
μg)
much
rebamipide
gets
instillation
drop
(1%
solution
(p
<
0.001).
method
offers
practical
reproducible
means
delivering
soft
lenses.
payloads
comparable
dosages
used
during
therapy.
Current Opinion in Allergy and Clinical Immunology,
Journal Year:
2023,
Volume and Issue:
23(5), P. 415 - 422
Published: July 24, 2023
Purpose
of
review
To
the
pathophysiology
and
treatment
ocular
itch
pain,
encompassing
nociceptive
neuropathic
categories.
Recent
findings
Ocular
pain
are
sensations
that
arise
from
activation
surface
polymodal
nerves.
Nociceptive
itch,
commonly
comorbid
with
complaints,
is
mainly
driven
by
a
histamine-mediated
type
1
hypersensitivity
reaction.
Beyond
topical
therapy,
novel
drug
delivery
systems
being
explored
to
improve
residence
time
nonsteroidal
anti-inflammatory
drugs
(NSAIDs)
antihistamines.
can
be
variety
factors.
Treatment
focuses
on
addressing
causative
sources
pain.
Neuropathic
nerve
damage
dysfunction
as
such,
oral
neuromodulation
have
been
treatments.
Oral
neuromodulators
include
alpha
2
delta
ligands,
tricyclic
antidepressants
(TCAs),
low
dose
naltrexone.
Novel
therapies
evaluated
for
both
modalities
such
difelikefalin
(κ-opioid
receptor
agonist)
libvatrep
(transient
potential
vanilloid
antagonist)
Summary
Both
and/or
mechanisms.
Identifying
contributors
abnormal
vital
precise
medical
care.
therapeutics
these
conditions
aim
patient
outcomes
quality
life.
Current Drug Delivery,
Journal Year:
2024,
Volume and Issue:
22(2), P. 140 - 159
Published: Jan. 12, 2024
Contact
lenses
(CLs)
have
become
an
essential
tool
in
ocular
drug
delivery,
providing
effective
treatment
options
for
specific
eye
conditions.
In
recent
advancements,
Therapeutic
CLs
(TCLs)
emerged
as
a
promising
approach
maintaining
therapeutic
concentrations
on
the
surface.
TCLs
offer
unique
attributes,
including
prolonged
wear
and
remarkable
ability
to
enhance
bioavailability
of
loaded
medications
by
more
than
50%,
thus
gaining
widespread
usage.
They
proven
beneficial
pain
management,
medication
administration,
corneal
healing,
protection.
To
achieve
sustained
delivery
from
TCLs,
researchers
are
exploring
diverse
systems,
such
polymeric
nanoparticulate
lipidic
incorporation
agents
like
vitamin
E
or
rate-limiting
polymers.
However,
despite
breakthrough
successes,
certain
challenges
persist,
ensuring
stability
during
processing
manufacturing,
controlling
release
kinetics,
biomaterial
interaction,
reducing
protein
adhesion,
addressing
packaging
storage
etc.
While
shown
overall
success
treating
surface
disorders,
careful
consideration
potential
issues
contraindications
is
vital.
This
review
offers
insightful
perspective
critical
aspects
that
need
be
addressed
regarding
with
emphasis
their
advantages
limitations.
Current Opinion in Allergy and Clinical Immunology,
Journal Year:
2024,
Volume and Issue:
24(5), P. 397 - 403
Published: Aug. 13, 2024
Integrative
medicine
techniques
are
increasingly
accepted
into
the
treatment
paradigm
for
many
chronic
disorders
including
eye
disease.
Over
71%
of
patients,
67%
those
with
disorders,
use
some
form
therapy.
Physicians
should
be
well
versed
in
evidence-based
therapies
to
know
how
refer
patients
best
complimentary
care.
We
highlight
most
effective
integrative
therapeutics
from
different
complementary
paradigms
offer
a
framework
approaching
therapy
ocular
surface
(OSDs).
Optometry and Vision Science,
Journal Year:
2024,
Volume and Issue:
101(11), P. 666 - 676
Published: Nov. 1, 2024
Vitamin
E
could
be
used
as
a
coating
with
commercial
silicone
hydrogel
lenses
to
extend
the
release
of
various
ophthalmic
drugs.
This
concept
provide
promising
approach
improve
overall
ocular
therapeutic
outcomes
for
topical
