Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 24, 2024
Abstract
Retinol
and
retinyl
palmitate,
with
excellent
whitening
antioxidant
activities,
are
widely
used
as
essential
functional
ingredients
in
transdermal
preparations
skincare
products.
Herein,
for
the
first
time,
influence
underlying
mechanisms
of
retinol
palmitate
on
skin
penetration
caffeine
investigated.
It
is
found
that
very
significantly
enhanced
by
2.83
2.57
folds,
respectively.
Mechanistic
studies
showed
they
can
disrupt
lipids
intercellular
orderly
arrangement
reduce
content
orthorhombic
lattices
skin,
making
loose
barrier
function
decreased.
Furthermore,
due
to
formation
chemical
bonds
keratin,
have
a
strong
affinity
changing
dense
secondary
structure
keratin
reduced
effect.
This
study
provides
new
evidence
potential
novel
enhancers
high
safety
possess
great
application
delivery
pharmaceutical
cosmetic
active
substances.
Processes,
Journal Year:
2023,
Volume and Issue:
11(7), P. 1986 - 1986
Published: June 30, 2023
In
this
study,
the
classification,
composition,
preparation
methods,
and
performance
parameters
of
deep
eutectic
solvents
(DESs)
their
recent
applications
in
natural
product
extraction,
drug
delivery
systems,
trace
metal
determination,
nanomaterial
synthesis,
electrochemistry
are
systematically
summarised
through
literature
decades,
using
DESs
as
keywords.
The
hydrogen
bond
acceptors
(HBA)
mainly
quaternary
ammonium
salts
(e.g.,
choline
chloride)
or
amphoteric
ions
betaine);
donors
(HBD)
mostly
compounds
such
urea,
polyols,
sugars.
Their
melting
points
related
to
bonding,
polarities
higher
than
most
ionic
liquids,
viscosities
generally
range
0.01–5
Pa·s.
Compared
with
traditional
organic
conventional
have
solubility,
ability
dissolve
oxides
insoluble
drugs,
good
biodegradability.
high
extraction
rates
flavonoids
phenols,
can
increase
solubility
effectively
extract
perform
pre-concentration
metals
synthesise
new
nanomaterial,
be
used
electrolytes
for
electrochemical
reactions
electrochemistry.
This
paper
collates
relevant
on
physicochemical
properties
multi-field
DESs,
which
provides
a
deeper
understanding
looks
forward
future
development
Applied Sciences,
Journal Year:
2023,
Volume and Issue:
13(13), P. 7826 - 7826
Published: July 3, 2023
Topical
drug
delivery
in
skin
diseases
provides
a
non-invasive,
direct
application
of
treatments
to
the
affected
area
and
avoids
systemic
toxicity.
Quercetin
is
natural
polyphenol
with
documented
activity
alleviate
symptoms
many
diseases.
The
objective
this
study
was
prepare
assess
physicochemical
properties
hydrogels
made
sodium
alginate
(SA)
cellulose
derivatives
(methyl
(MC)
carboxymethyl
(CMC)),
containing
different
concentrations
quercetin
(0.4
0.7%).
evaluation
obtained
included
organoleptic
evaluation,
texture
analysis,
spreadability,
rheological
properties,
pH,
stability.
Among
prepared
formulations,
MC-based
gels
had
highest
viscosity,
adhesiveness,
cohesiveness,
stickiness.
results
indicate
that
were
superior
CMC-
or
SA-based
their
ability
effectively
deliver
porcine
ex
vivo.
amount
retained
after
preparations
higher
2.04-fold
for
CMC-based
2.6-fold
hydrogels.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 21, 2024
Transdermal
delivery
of
sparingly
soluble
drugs
is
challenging
due
to
their
low
solubility
and
poor
permeability.
Deep
eutectic
solvent
(DES)/or
ionic
liquid
(IL)-mediated
nanocarriers
are
attracting
increasing
attention.
However,
most
them
require
the
addition
auxiliary
materials
(such
as
surfactants
or
organic
solvents)
maintain
stability
formulations,
which
may
cause
skin
irritation
potential
toxicity.
