The
increasing
popularity
of
prolonged-release
dosage
forms,
owing
to
their
ability
provide
continuous
drug
release
after
administration,
has
significantly
improved
patient
compliance
and
overall
quality
life.
However,
achieving
prolonged
beyond
24
h
frequently
requires
the
use
invasive
methods,
including
injections
or
implants,
which
may
prove
challenging
for
people
suffering
from
needle
phobia.
This
study
introduces
atorvastatin
(ATR)
microparticles
(MPs)
nanocrystal
(NCs)
dissolving
microarray
patches
(D-MAPs)
as
a
noninvasive
alternative
intradermal
delivery
over
two-week
period
management
hyperlipidemia.
MP-loaded
D-MAPs
exhibited
an
average
loading
5.15
±
0.4
mg
ATR
per
patch,
surpassing
2.4
0.11
mg/patch
observed
with
NC-loaded
D-MAPs.
Skin
deposition
studies
demonstrated
superior
performance
MP
D-MAPs,
delivered
2.0
0.33
0.75
cm
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(18), P. 4375 - 4388
Published: Jan. 1, 2024
SmartReservoirs
(SRs)
are
novel
drug-reservoirs
for
hydrogel-forming
microneedles
(HF-MNs).
SRs
improved
rifampicin
solubility
and
diffusion
through
the
HF-matrix,
thereby
enhancing
transdermal
permeation
of
poorly
soluble
antibiotic.
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(6), P. 2781 - 2794
Published: April 27, 2024
The
nanocrystal
(NC)
technology
has
become
one
of
the
most
commonly
used
strategies
for
formulation
poorly
soluble
actives.
Given
their
large
specific
surface,
NCs
are
mainly
to
enhance
oral
absorption
Differently
from
conventional
nanoparticles,
which
require
use
carrier
materials
and
have
limited
drug
loadings,
NCs'
loading
approaches
100%
since
they
formed
pure
surrounded
by
a
thin
layer
stabilizer.
In
this
work,
we
report
covalent
decoration
curcumin
with
folic
acid
(FA)
using
EDC/NHS
chemistry
explore
novel
systems
as
highly
loaded
"Trojan
horses"
target
cancer
cells.
decorated
demonstrated
remarkable
improvement
in
uptake,
exhibiting
enhanced
growth
inhibition
cells
(HeLa
MCF7)
while
sparing
healthy
(J774A.1).
Cellular
uptake
studies
revealed
significantly
heightened
entry
FA-decorated
into
compared
unmodified
also
showing
reduced
macrophages,
indicating
potential
prolonged
circulation
vivo.
These
findings
underline
NC
nanovectors
delivery
and,
particular,
therapies,
effectively
targeting
folate
receptor-overexpressing
evading
interception
thus
preserving
viability
offering
promising
avenue
precise
effective
treatments.
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(5), P. 052009 - 052009
Published: Aug. 27, 2024
Abstract
Curcumin
is
a
natural
polyphenolic
compound
extracted
from
turmeric
with
antibacterial,
antioxidant,
antitumor,
preventive
and
therapeutic
neurological
disorders
variety
of
bioactivities,
which
widely
used
in
the
field
food
medicine.
However,
drawbacks
curcumin
such
as
poor
aqueous
solubility
stability
have
limited
practical
application
curcumin.
To
overcome
these
defects
enhance
its
functional
properties,
various
nanoscale
systems
(liposomes,
polymer
nanoparticles,
protein
solid
lipid
metal
etc)
been
extensively
employed
for
encapsulation
delivery.
Despite
rapid
development
nanoformulations,
there
lack
comprehensive
reviews
on
their
preparation
properties.
This
review
provides
an
overview
construction
nano-delivery
systems,
mechanisms
action,
nanocarrier
methods
applications
nanocarriers
pharmaceutical
fields
to
provide
theoretical
basis
technological
support
efficient
bio-utilization,
product
early
clinical
Advanced Therapeutics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 25, 2024
Abstract
Drug
delivery
to
mucosal
tissues
presents
considerable
challenges
related
the
complex
nature
of
mucus
layer
protecting
such
tissues.
This
aggravates
when
delivering
hydrophobic
drugs,
often
requiring
incorporation
drugs
nanoparticles
and
use
mucoadhesive
systems.
paper
aimed
develop
an
antifungal
chitosan
(CHI)‐based
film
loading
itraconazole
(ITZ)
nanocrystals
(NCs)
with
precisely
controlled
surface
charge
for
enhanced
mucoadhesion.
Cationic
anionic
ITZ
NCs
are
prepared
using
wet
media
milling
mean
particle
sizes
zeta
potentials
226.9
±
1.4
nm
234.0
2.90
nm,
+15.4
2.8
mV
−16.2
1.3
mV,
cationic
NCs,
respectively.
ITZ‐NCs
exhibits
a
higher
affinity
mucin
particles.
NCs‐loaded
films
showed
stronger
mechanical
properties
adhesiveness
compared
powder‐loaded
films.
Physicochemical
analysis
reveals
that
crystalline
preserved,
no
drug‐excipients
interaction.
A
significantly
amount
deposition
is
obtained
from
containing
(1360.23
718.73
µg
cm
−2
)
powder
(58.83
37.45
).
work
demonstrates
feasibility
tailoring
surface,
resultant
systems
showing
potential
management
fungal
infections
in
Advances in Pharmacological and Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Curcumin
has
shown
beneficial
effects
on
pulmonary
diseases
with
chronic
inflammation
or
abnormal
inflammatory
responses,
including
obstructive
disease,
asthma,
and
fibrosis.
Clinical
applications
of
curcumin
are
limited
due
to
its
chemical
instability
in
solution,
low
water
solubility,
poor
oral
bioavailability,
intestinal
liver
first-pass
metabolism.
Pulmonary
delivery
can
address
these
challenges
provide
a
high
concentration
lung
tissues.
The
purpose
the
current
work
was
prepare
novel
inhalable
dry
powder
nanocrystals
without
added
excipients
using
electrospray
drying
(ED)
improved
dissolution
aerosolization
properties.
ED
performed
at
2
4%
w/v
concentrations
acetone.
Physicochemical
properties
formulated
powders
were
evaluated
by
X-ray
diffraction
(PXRD),
Fourier
transform
infrared
spectroscopy
(FTIR),
scanning
electron
microscopy
(SEM),
density
flow
measurements,
vitro
dissolution.
deposition
studies
conducted
next-generation
impactor
(NGI)
aerosol
performance
aerodynamic
particle
size
parameters
calculated
for
prepared
formulations.
could
produce
agglomerates
about
500
nm
an
acceptable
yield
50%.
PXRD
FTIR
data
revealed
that
stable
crystalline
state.
bulk
tapped
range
appropriate
delivery.
Formed
significantly
improve
rate
water-insoluble
curcumin.
optimized
formulation
exhibited
recovered
dose
percentage,
emitted
optimum
mean
mass
median
diameter,
small
geometric
standard
deviation,
fine-particle
fraction
favors
deep
regions.
proved
be
efficient
technique
single
step,
mild
condition,
no
surfactant.
