International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125156 - 125156
Published: Dec. 1, 2024
Language: Английский
Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1177 - 1192
Published: Dec. 1, 2024
Language: Английский
Citations
2
BioNanoScience, Journal Year: 2024, Volume and Issue: 14(3), P. 2159 - 2169
Published: July 9, 2024
Language: Английский
Citations
1
Materials & Design, Journal Year: 2024, Volume and Issue: 240, P. 112820 - 112820
Published: Feb. 29, 2024
Mucus clearance, epithelium mucosal barrier and P-glycoprotein (P-gp) efflux are the main gastrointestinal barriers that limit oral delivery of nanoparticles. Inspired by tunable particles surface properties-dependent trans-mucus trans-mucosal abilities, novel bilayer-functionalized mesoporous silica nanoparticles (MSN) containing D-α-tocopheryl polyethylene glycol succinate (TPGS) sulfobetaine 12 (SB12) were designed layer-to-layer assembly. The amino-grafted MSN (MSN-NH2) was firstly functionalized with TPGS as hydrophobic layer (MSN-TPGS), then SB12 self-assembled on MSN-TPGS to generate a neutral hydrophilic (MSN-TPGS@SB12). Compared MSN-NH2, MSN-TPGS, MSN-TPGS@P123, MSN-TPGS@SB12 possessed "one stone three birds" functions enhanced mucus penetration, increased absorption, well suppressed P-gp efflux. pharmacokinetics study demonstrated loading puerarin (MSN-TPGS@SB12-PUE) exhibited much higher bioavailability compared other PUE-loaded formulations. Furthermore, MSN-TPGS@SB12-PUE could significantly enhance anti-inflammatory efficacy PUE in vitro vivo. In summary, is promising vehicle for overcoming multiple (mucus intestinal efflux). Meanwhile, this also provides better understanding importance property drug.
Language: Английский
Citations
0
Journal of Nanotechnology, Journal Year: 2024, Volume and Issue: 2024(1)
Published: Jan. 1, 2024
MS‐275, a histone deacetylase inhibitor, has proven anticancer activities against various malignancies. However, its clinical application been constrained by dose‐limiting toxicity, off‐target effects, and variable outcomes. Clinical data suggest that sustained low MS‐275 doses could achieve more selective consistent effect. This study aimed at enhancing the activity of encapsulating it in D‐ α ‐tocopheryl polyethylene glycol 1000 succinate (TPGS) micelles. The produced nanoformulations were characterized their polydispersity (0.201), negative zeta potential (−0.397 mV), high entrapment efficiency (98.8%). Experimental evaluation formulation showed significant reduction HepG2, HCT116, MCF7 cells’ viability, associated with enhanced apoptosis lower IC 50 compared to alone. was further examined on cancer cells xenografted chorioallantoic membrane (CAM) chick embryos. results substantial tumor size. TPGS micelles alone induced an accumulation G1 slightly reduced cellular viability cell lines. Our represents promising strategy enhance therapeutic impact while minimizing pharmacological dosage.
Language: Английский
Citations
0
Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110529 - 110529
Published: Oct. 1, 2024
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125156 - 125156
Published: Dec. 1, 2024
Language: Английский
Citations
0