Selected Flavonols Targeting Cell Death Pathways in Cancer Therapy: The Latest Achievements in Research on Apoptosis, Autophagy, Necroptosis, Pyroptosis, Ferroptosis, and Cuproptosis

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1201 - 1201

Published: April 18, 2024

The complex and multi-stage processes of carcinogenesis are accompanied by a number phenomena related to the potential involvement various chemopreventive factors, which include, among others, compounds natural origin such as flavonols. use flavonols is not only promising but also recognized strategy for cancer treatment. impact on arises from their ability act antioxidants, impede proliferation, promote cell death, inhibit angiogenesis, regulate immune system through in diverse forms cellular death. So far, molecular mechanisms underlying regulation apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, cuproptosis occurring with participation have remained incompletely elucidated, results studies carried out so far ambiguous. For this reason, one therapeutic goals initiate death altered cells quercetin, kaempferol, myricetin, isorhamnetin, galangin, fisetin, morin. This article offers an extensive overview recent research these compounds, focusing particularly role combating elucidating governing cuproptosis. Assessment anticancer effects therapy targeting types pathways may prove useful developing new regimens counteracting resistance previously used treatments.

Language: Английский

Targeting regulated cell death (RCD) in hematological malignancies: Recent advances and therapeutic potential

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116667 - 116667

Published: May 3, 2024

Regulated cell death (RCD) is a form of that can be regulated by numerous biomacromolecules. Accumulating evidence suggests dysregulated expression and altered localization related proteins in RCD promote the development cancer. Targeting subroutines with pharmacological small-molecule compounds becoming promising therapeutic avenue for anti-tumor treatment, especially hematological malignancies. Herein, we summarize aberrant mechanisms apoptosis, necroptosis, pyroptosis, PANoptosis, ferroptosis In particular, focus on relationship between tumorigenesis, immunotherapy, drug resistance Furthermore, discuss emerging strategies targeting different subroutines. This review aims to significance potential malignancies, along utilization pertinent strategies.

Language: Английский