Materials Today Communications, Journal Year: 2024, Volume and Issue: 42, P. 111279 - 111279
Published: Dec. 10, 2024
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117219 - 117219
Published: July 30, 2024
A transdermal delivery system offers high bioavailability and favorable patient adherence, constituting an optimal approach for localized administration in rheumatoid arthritis (RA) treatment. However, the stratum corneum (SC) impedes efficiency of conventional drug systems. Microneedles (MNs) can temporarily create micropores within SC, enabling distribution via bypassing this barrier enhancing effectiveness. Notably, MNs provide a painless method through skin may directly modulate inflammation immune cells by delivering drugs lymphatic during administration. MN is not suitable with low water solubility stability. Additionally, major concerns exist regarding safety using highly cytotoxic drugs, given that it could result local concentration at site. While exhibit some degree targeted to inflammatory environment, their targeting remains suboptimal. Nanoformulations have potential significantly address limitations RA treatment improving targeting, solubility, stability, biocompatibility. Therefore, review provides concise overview advantages, disadvantages, mechanisms different types It specifically focuses on application advantages combining nanoformulation summarizes current trends development nanoformulations combined field treatment, offering theoretical support future advancements clinical applications.
Language: Английский
Citations
5
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124995 - 124995
Published: Nov. 1, 2024
Language: Английский
Citations
4
Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
It is well known that impaired wound healing associated with diabetes mellitus has led to a challenging problem as global economic healthcare burden. Conventional care therapies like films, gauze, and bandages fail cure diabetic wounds, thereby demanding synergistic promising therapy. This investigation aimed develop novel, greener synthesis of laser-responsive silver nanocolloid (LR-SNC) prepared using hyaluronic acid bioreductant. The LR-SNC was embedded into stimuli-responsive in situ gel (LR-SNC-in gel) for easy application the region. physicochemical characterization revealed nanometric hydrodynamic particle size 25.59 ± 0.72 nm an −31.8 0.7 mV surface ζ-potential. photothermal conversion efficiency observed up 62.9 0.1 °C. In vitro evaluation without NIR laser irradiation exhibited >70% cell viability, confirming its cytocompatibility human keratinocyte cells. scratch assay showed significant closure 75.50 0.02%. Further, addition cytocompatible followed by resulted substantial vivo (86.69 2.48%) wound-bearing mouse. Histological demonstrated salient features healed such increased neovascularization, collagen density, migration keratinocytes, growth hair follicles. Additionally, findings decrease levels pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) enhanced angiogenesis gene expression (VEGF CD31), efficiently. present study confirmed potential role nanocolloids treating mouse models.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101522 - 101522
Published: Jan. 25, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Abstract The skin microenvironment is a highly intricate and dynamic system, characterized by an acidic pH, diverse microbiota, various metabolites, numerous enzymes, creating both challenges opportunities for the development of innovative drug delivery systems. Dissolving Microneedles (MNs) have emerged as promising, pain‐free alternative to conventional invasive injections, offering ability deliver therapeutics through gradual degradation within skin's interstitial fluids. Building upon unique properties dissolving MNs, novel concept introduced wherein MNs serve in situ chemical reaction chambers. In this framework, can reactants or catalysts skin, enabling initiation specific reactions, such prodrug activation targeted therapy, harmful enhanced synthesis beneficial molecules. Moreover, review systematically explores potential chambers, discussing key aspects their sustained release mechanisms, design strategies, range therapeutic applications. Finally, forward‐looking perspective provided on future addressing broader clinical translation application personalized medicine.
Language: Английский
Citations
0
Materials Today Sustainability, Journal Year: 2024, Volume and Issue: 28, P. 100975 - 100975
Published: Sept. 6, 2024
Language: Английский
Citations
3
Materials Today Communications, Journal Year: 2024, Volume and Issue: 42, P. 111279 - 111279
Published: Dec. 10, 2024
Language: Английский
Citations
0