Nanomaterial-functionalized electrospun scaffolds for tissue engineering DOI
Kilole Tesfaye Chaka, Kai Cao, Tamrat Tesfaye

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 43

Published: Sept. 11, 2024

Tissue engineering has emerged as a biological alternative aimed at sustaining, rehabilitating, or enhancing the functionality of tissues that have experienced partial complete loss their operational capabilities. The distinctive characteristics electrospun nanofibrous structures, such elevated surface-area-to-volume ratio, specific pore sizes, and fine fiber diameters, make them suitable effective scaffolds in tissue engineering, capable mimicking functions targeted tissue. However, nanofibers, whether derived from natural synthetic polymers combinations, often fall short replicating multifunctional attributes extracellular matrix (ECM). To address this, nanomaterials (NMs) are integrated into polymeric through various functionalization techniques to enhance properties. Incorporation NMs imparts unique features, including high surface area, superior mechanical properties, compositional variety, structural adaptability, exceptional porosity, enhanced capabilities for promoting cell migration proliferation. This review provides comprehensive overview types NMs, methodologies used integration scaffolds, recent advancements NM-functionalized regenerating bone, cardiac, cartilage, nerve, vascular tissues. Moreover, main challenges, limitations, prospects elaborated.

Language: Английский

Synthesis and Characterization of Cu-Vanadate Doped Hydroxyapatite Nanoparticles: Morphological, Structural, and Stability for Biomedical Use DOI
Manal M. Alkhamisi

Journal of the Australian Ceramic Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Language: Английский

Citations

0
Superhydrophililc tin doped hyrdoxyapatite films using Galatea paradoxa shells DOI
Yao Mawuena Tsekpo, Tomasz Tański, Weronika Smok

et al.

Surface and Coatings Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132087 - 132087

Published: March 1, 2025

Language: Английский

Citations

0
Macromolecule-based stem cell and cell-free strategies for oral and maxillofacial tissue repair DOI Creative Commons

Xinying Wang,

Liming He, Yiyu Zeng

et al.

Materials & Design, Journal Year: 2024, Volume and Issue: 244, P. 113203 - 113203

Published: July 29, 2024

The oral and maxillofacial regions perform mastication, swallowing, speech, expression; therefore, tissue defects can seriously affect patient physical mental health. Biomaterials be used to repair defects. However, traditional biomaterials lack biocompatibility cannot accurately match the shape of damaged tissues, leading immune rejection chronic inflammation, thereby limiting their ability. improve mesenchymal stem cell (MSC) survival by simulating extracellular matrix (ECM). MSCs have excellent self-regenerative abilities differentiate into almost all types, making them valuable for engineering. This review summarizes biomaterial-based, cell, cell-free therapies discusses properties, advantages, disadvantages, application mechanisms, with a particular focus on use in defect regeneration limitations current materials strategies. provides insights using regeneration.

Language: Английский

Citations

1
True-bone-ceramics / type I collagen scaffolds for repairing osteochondral defect DOI Creative Commons
Yuhan Jiang,

Tenghai Li,

Yingyue Lou

et al.

Journal of Materials Science Materials in Medicine, Journal Year: 2024, Volume and Issue: 36(1)

Published: Dec. 30, 2024

In recent years, the incidence of cartilage defects has increased dramatically, and its etiology is complex varied. Osteochondritis dissecans (OCD), as one main etiologies, damages both bone tissues can progress to severe osteoarthritis, which been difficult problems for clinicians. The vigorous development material science tissue engineering provides new ideas treatment OCD, in selection scaffold materials particularly important. this study, true-bone-ceramics (TBC), good mechanical strength osteoconductivity, type I collagen (COL1), excellent biocompatibility, were chosen co-construct TBC/COL1 osteochondral repair. order ensure most appropriate coating concentration, three experimental groups (1, 5, 12 mg/ml) set up. Through physicochemical property test, biocompatibility analysis vivo implantation experiments composite scaffolds, mg/ml scaffolds present best repair effect among groups.

Language: Английский

Citations

1
Advances in Antibiotic-Loaded Nanofibers for the Treatment of Bone Infections: A Review DOI Open Access
Teguh Imanto, Nonni Soraya Sambudi, Khadijah Zai

et al.

Pharmacon Jurnal Farmasi Indonesia, Journal Year: 2024, Volume and Issue: unknown, P. 161 - 175

Published: Dec. 31, 2024

Antibiotic-loaded nanofiber-based drug delivery systems represent a novel approach to treating complex bone infections, particularly osteomyelitis caused by antibiotic-resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA). These offer localized, sustained release, significantly reducing systemic side effects and mitigating the development of antibiotic resistance. This review evaluates advancements in electrospun nanofibers with biodegradable polymers like Poly(lactic-co-glycolic acid) (PLGA) Polycaprolactone (PCL), which ensure controlled release while supporting regeneration. A systematic search using PRISMA guidelines across ScienceDirect ACS Publication databases (2020-2024) identified 42 relevant studies. The inclusion bioactive agents hydroxyapatite was found enhance antibacterial properties accelerate tissue demonstrates that antibiotic-loaded promising, targeted therapeutic alternative conventional treatments, for similar challenging infections. Future research directions will focus on optimizing nanofiber compositions functionalities better meet clinical needs, ensuring more efficient personalized management severe

Language: Английский

Citations

0
Nanomaterial-functionalized electrospun scaffolds for tissue engineering DOI
Kilole Tesfaye Chaka, Kai Cao, Tamrat Tesfaye

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 43

Published: Sept. 11, 2024

Tissue engineering has emerged as a biological alternative aimed at sustaining, rehabilitating, or enhancing the functionality of tissues that have experienced partial complete loss their operational capabilities. The distinctive characteristics electrospun nanofibrous structures, such elevated surface-area-to-volume ratio, specific pore sizes, and fine fiber diameters, make them suitable effective scaffolds in tissue engineering, capable mimicking functions targeted tissue. However, nanofibers, whether derived from natural synthetic polymers combinations, often fall short replicating multifunctional attributes extracellular matrix (ECM). To address this, nanomaterials (NMs) are integrated into polymeric through various functionalization techniques to enhance properties. Incorporation NMs imparts unique features, including high surface area, superior mechanical properties, compositional variety, structural adaptability, exceptional porosity, enhanced capabilities for promoting cell migration proliferation. This review provides comprehensive overview types NMs, methodologies used integration scaffolds, recent advancements NM-functionalized regenerating bone, cardiac, cartilage, nerve, vascular tissues. Moreover, main challenges, limitations, prospects elaborated.

Language: Английский

Citations

0