Nanotechnological Formulation Incorporating Pectis brevipedunculata (Asteraceae) Essential Oil: An Ecofriendly Approach for Leishmanicidal and Anti-Inflammatory Therapy

Polymers, Journal Year: 2025, Volume and Issue: 17(3), P. 379 - 379

Published: Jan. 30, 2025

Cutaneous leishmaniasis caused by Leishmania amazonensis is a significant public health issue. This study aimed to evaluate an ecofriendly, thermosensitive nanogel, developed using low-energy, solvent-free method, incorporating F127 and Carbopol 974P copolymers, enriched with Pectis brevipedunculata essential oil (EOPb) for its leishmanicidal anti-inflammatory properties. The nanogel was prepared characterized through FTIR, DLS, SEM, AFM confirm the incorporation of EOPb as well stability rheological In vitro activity evaluated on promastigotes, in vivo effects were assessed rat paw edema model. vitro, nGF3 (EOPb-loaded nanogel) demonstrated activity, promastigote mortality rates exceeding 80% at 24 h 90% 48 h. vivo, nGF1, nGF2, exhibited effects, nGF2 reducing 62.7% 2 post-treatment. empty (nGF0) showed minimal activity. ecofriendly EOPb-loaded (nGF3) strong presenting promising candidate cutaneous treatment. Further studies are necessary explore clinical potential.

Language: Английский

Leveraging Microneedles for Raised Scar Management

Polymers, Journal Year: 2025, Volume and Issue: 17(1), P. 108 - 108

Published: Jan. 2, 2025

Disruption of the molecular pathways during physiological wound healing can lead to raised scar formation, characterized by rigid, thick tissue with associated symptoms pain and pruritus. A key mechanical factor in development is excessive tension at site. Recently, microneedles (MNs) have emerged as promising tools for management they engage provide them off-loading from both internal external sources. This review explores mechanisms which physical intervention drug-free MNs alleviates on fibroblasts within tissue, thereby promoting remodeling reducing severity. Additionally, role an efficient cargo delivery system controlled sustained release a wide range therapeutic agents into highlighted. By penetrating facilitate localized drug administration modulate inflammation fibroblastic cell growth. Finally, remaining challenges future perspective field been

Language: Английский

Phaseolus lunatus L. polysaccharide microneedles loaded with sinomenine hydrochloride for synergistic rheumatoid arthritis management and analgesia

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141511 - 141511

Published: March 1, 2025

Language: Английский