Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(29)
Published: Aug. 18, 2024
Abstract
Over
the
last
four
decades,
pharmaceutical
companies’
expenditures
on
research
and
development
have
increased
51‐fold.
During
this
same
time,
clinical
success
rates
for
new
drugs
remained
unchanged
at
about
10
percent,
predominantly
due
to
lack
of
efficacy
and/or
safety
concerns.
This
persistent
problem
underscores
need
innovate
across
entire
drug
process,
particularly
in
formulation,
which
is
often
deprioritized
under‐resourced.
Journal of Controlled Release,
Journal Year:
2022,
Volume and Issue:
353, P. 1107 - 1126
Published: Dec. 25, 2022
Colonic
drug
delivery
can
facilitate
access
to
unique
therapeutic
targets
and
has
the
potential
enhance
bioavailability
whilst
reducing
off-target
effects.
Delivering
drugs
colon
requires
considered
formulation
development,
as
both
oral
rectal
dosage
forms
encounter
challenges
if
colon's
distinct
physiological
environment
is
not
appreciated.
As
opportunities
surrounding
colonic
multiply,
success
of
novel
pharmaceuticals
lies
in
their
design.
This
review
provides
a
modern
insight
into
key
parameters
determining
effective
design
development
colon-targeted
medicines.
Influential
features
governing
release,
dissolution,
stability,
absorption
are
first
discussed,
followed
by
an
overview
most
reliable
strategies.
Finally,
appropriate
vitro,
vivo,
silico
preclinical
investigations
presented,
with
goal
inspiring
strategic
new
therapeutics.
International Journal of Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
631, P. 122480 - 122480
Published: Dec. 9, 2022
Three-dimensional
(3D)
printing
is
an
emerging
technology
with
great
potential
in
pharmaceutical
applications,
providing
innovative
solutions
for
both
patients
and
industry.
This
offers
precise
construction
of
the
structure
dosage
forms
can
benefit
drug
product
design
by
versatile
release
modes
to
meet
clinical
needs
facilitating
patient-centric
treatment,
such
as
personalized
dosing,
accommodate
treatment
specific
disease
states
or
patient
populations.
Utilization
3D
also
facilitates
digital
development
manufacturing.
Development
at
early
stages
commercial
scale
manufacturing
has
substantially
advanced
recent
years.
In
this
review,
we
discuss
how
accelerates
early-stage
development,
including
pre-clinical
research
phase
human
studies,
late-stage
well
patients.
The
advantages,
current
status,
challenges
employing
large
dosing
are
introduced
respectively.
considerations
efforts
regulatory
agencies
address
discussed.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2023,
Volume and Issue:
143, P. 105930 - 105930
Published: May 27, 2023
3D
printing,
also
known
as
Additive
manufacturing
(AM),
has
emerged
a
transformative
technology
with
applications
across
various
industries,
including
the
medical
sector.
This
review
paper
provides
an
overview
of
current
status
AM
technology,
its
challenges,
and
application
in
industry.
The
covers
different
types
technologies,
such
fused
deposition
modeling,
stereolithography,
selective
laser
sintering,
digital
light
processing,
binder
jetting,
electron
beam
melting,
their
suitability
for
applications.
most
commonly
used
biomedical
materials
AM,
plastic,
metal,
ceramic,
composite,
bio-inks,
are
viewed.
challenges
material
selection,
accuracy,
precision,
regulatory
compliance,
cost
quality
control,
standardization,
discussed.
highlights
sector,
production
patient-specific
surgical
guides,
prosthetics,
orthotics,
implants.
Finally,
Internet
Medical
Things
(IoMT)
artificial
intelligence
(AI)
frameworks
safety
standards
3D-printed
devices.
concludes
that
can
transform
healthcare
industry
by
enabling
patients
to
access
more
personalized
reasonably
priced
treatment
alternatives.
Despite
integrating
AI
IoMT
printing
is
expected
play
vital
role
future
device
applications,
leading
further
advancements
improvements
patient
care.
More
research
needed
address
optimize
use
utilize
AM's
potential
fully.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(34)
Published: March 8, 2024
In
recent
years,
there
has
been
widespread
adoption
of
machine
learning
(ML)
technologies
to
unravel
intricate
relationships
among
diverse
parameters
in
various
additive
manufacturing
(AM)
techniques.
These
ML
models
excel
at
recognizing
complex
patterns
from
extensive,
well-curated
datasets,
thereby
unveiling
latent
knowledge
crucial
for
informed
decision-making
during
the
AM
process.
The
collaborative
synergy
between
and
holds
potential
revolutionize
design
production
AM-printed
parts.
This
review
delves
into
challenges
opportunities
emerging
intersection
these
two
dynamic
fields.
It
provides
a
comprehensive
analysis
publication
landscape
ML-related
research
field
AM,
explores
common
applications
(such
as
quality
control,
process
optimization,
microstructure
analysis,
material
formulation),
concludes
by
presenting
an
outlook
that
underscores
utilization
advanced
models,
development
sensors,
AM-related
Notably,
garnered
increased
attention
due
its
superior
performance
across
applications.
is
envisioned
integration
processes
will
significantly
enhance
3D
printing
capabilities
areas.
International Journal of Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
633, P. 122628 - 122628
Published: Jan. 20, 2023
Three-dimensional
(3D)
printing
is
drastically
redefining
medicine
production,
offering
digital
precision
and
personalized
design
opportunities.
One
emerging
3D
technology
selective
laser
sintering
(SLS),
which
garnering
attention
for
its
high
precision,
compatibility
with
a
wide
range
of
pharmaceutical
materials,
including
low-solubility
compounds.
However,
the
full
potential
SLS
medicines
yet
to
be
realized,
requiring
expertise
considerable
time-consuming
resource-intensive
trial-and-error
research.
Machine
learning
(ML),
subset
artificial
intelligence,
an
in
silico
tool
that
accomplishing
remarkable
breakthroughs
several
sectors
ability
make
highly
accurate
predictions.
Therefore,
present
study
harnessed
ML
predict
printability
formulations.
Using
dataset
170
formulations
from
78
models
were
developed
inputs
included
formulation
composition
characterization
data
retrieved
Fourier-transformed
infrared
spectroscopy
(FT-IR),
X-ray
powder
diffraction
(XRPD)
differential
scanning
calorimetry
(DSC).
Multiple
explored,
supervised
unsupervised
approaches.
The
results
revealed
can
achieve
accuracies,
by
using
leading
maximum
F1
score
81.9%.
FT-IR,
XRPD
DSC
as
resulted
84.2%,
81.3%,
80.1%,
respectively.
A
subsequent
pipeline
was
built
combine
predictions
into
one
consensus
model,
where
found
further
increase
88.9%.
it
determined
first
time
benefit
multi-modal
data,
combining
numeric,
spectral,
thermogram
data.
lays
groundwork
leveraging
existing
developing
high-performing
computational
accelerate
development.
Annals of 3D Printed Medicine,
Journal Year:
2024,
Volume and Issue:
14, P. 100149 - 100149
Published: Feb. 7, 2024
3D
printing,
or
additive
manufacturing,
has
transformed
various
industries
with
its
layer-by-layer
fabrication
approach.
In
medicine,
biofabrication,
seen
significant
advancements,
particularly
in
the
creation
of
patient-specific
medical
models
and
custom-made
drug
tablets.
Bioprinting,
a
key
aspect
encompasses
three
approaches:
biomimicry,
autonomous
self-assembly,
microtissues,
each
unique
advantages
disadvantages.
This
comprehensive
review
explores
merits
limitations
these
bioprinting
approaches
outlines
main
phases
entire
process:
pre-processing,
processing,
post-processing.
By
enhancing
patients'
quality
life,
reducing
healthcare
costs,
tapping
into
global
device
market,
biofabrication
technologies
hold
immense
promise
for
future
medicine.
literature
focuses
on
applications
printing
creating
devices,
including
bone
tissues,
joint
printed
tablets,
models.
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
653, P. 123902 - 123902
Published: Feb. 14, 2024
Three-dimensional
printing
(3DP)
is
an
emerging
technology,
offering
the
possibility
for
development
of
dose-customized,
effective,
and
safe
solid
oral
dosage
forms
(SODFs).
Although
3DP
has
great
potential,
it
does
come
with
certain
limitations,
traditional
drug
manufacturing
platforms
remain
industry
standard.
The
consensus
appears
to
be
that
technology
expected
benefit
personalized
medicine
most,
but
unlikely
replace
conventional
mass
production.
method,
on
other
hand,
could
prove
well-suited
producing
small
batches
as
adaptive
technique
enabling
clinical
trial
design
early
studies.
purpose
this
review
discuss
recent
advancements
in
technologies
SODFs
focus
applications
stages,
including
a
discussion
current
regulatory
challenges
quality
controls.
