The Dawn of a New Pharmaceutical Epoch: Can AI and Robotics Reshape Drug Formulation? DOI Creative Commons
Pauric Bannigan, Riley J. Hickman, Alán Aspuru‐Guzik

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(29)

Published: Aug. 18, 2024

Abstract Over the last four decades, pharmaceutical companies’ expenditures on research and development have increased 51‐fold. During this same time, clinical success rates for new drugs remained unchanged at about 10 percent, predominantly due to lack of efficacy and/or safety concerns. This persistent problem underscores need innovate across entire drug process, particularly in formulation, which is often deprioritized under‐resourced.

Language: Английский

Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics DOI Creative Commons
Laura E. McCoubrey,

Alessia Favaron,

Atheer Awad

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 353, P. 1107 - 1126

Published: Dec. 25, 2022

Colonic drug delivery can facilitate access to unique therapeutic targets and has the potential enhance bioavailability whilst reducing off-target effects. Delivering drugs colon requires considered formulation development, as both oral rectal dosage forms encounter challenges if colon's distinct physiological environment is not appreciated. As opportunities surrounding colonic multiply, success of novel pharmaceuticals lies in their design. This review provides a modern insight into key parameters determining effective design development colon-targeted medicines. Influential features governing release, dissolution, stability, absorption are first discussed, followed by an overview most reliable strategies. Finally, appropriate vitro, vivo, silico preclinical investigations presented, with goal inspiring strategic new therapeutics.

Language: Английский

Citations

121

3D printing: Innovative solutions for patients and pharmaceutical industry DOI Creative Commons

Timothy S. Tracy,

Lei Wu, Xin Liu

et al.

International Journal of Pharmaceutics, Journal Year: 2022, Volume and Issue: 631, P. 122480 - 122480

Published: Dec. 9, 2022

Three-dimensional (3D) printing is an emerging technology with great potential in pharmaceutical applications, providing innovative solutions for both patients and industry. This offers precise construction of the structure dosage forms can benefit drug product design by versatile release modes to meet clinical needs facilitating patient-centric treatment, such as personalized dosing, accommodate treatment specific disease states or patient populations. Utilization 3D also facilitates digital development manufacturing. Development at early stages commercial scale manufacturing has substantially advanced recent years. In this review, we discuss how accelerates early-stage development, including pre-clinical research phase human studies, late-stage well patients. The advantages, current status, challenges employing large dosing are introduced respectively. considerations efforts regulatory agencies address discussed.

Language: Английский

Citations

89

3D printed biomedical devices and their applications: A review on state-of-the-art technologies, existing challenges, and future perspectives DOI Creative Commons
Hana Beyene Mamo, Marcin Adamiak, Anil Kunwar

et al.

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2023, Volume and Issue: 143, P. 105930 - 105930

Published: May 27, 2023

3D printing, also known as Additive manufacturing (AM), has emerged a transformative technology with applications across various industries, including the medical sector. This review paper provides an overview of current status AM technology, its challenges, and application in industry. The covers different types technologies, such fused deposition modeling, stereolithography, selective laser sintering, digital light processing, binder jetting, electron beam melting, their suitability for applications. most commonly used biomedical materials AM, plastic, metal, ceramic, composite, bio-inks, are viewed. challenges material selection, accuracy, precision, regulatory compliance, cost quality control, standardization, discussed. highlights sector, production patient-specific surgical guides, prosthetics, orthotics, implants. Finally, Internet Medical Things (IoMT) artificial intelligence (AI) frameworks safety standards 3D-printed devices. concludes that can transform healthcare industry by enabling patients to access more personalized reasonably priced treatment alternatives. Despite integrating AI IoMT printing is expected play vital role future device applications, leading further advancements improvements patient care. More research needed address optimize use utilize AM's potential fully.

Language: Английский

Citations

86

Progress and Opportunities for Machine Learning in Materials and Processes of Additive Manufacturing DOI Creative Commons
Wei Long Ng, Guo Liang Goh, Guo Dong Goh

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(34)

Published: March 8, 2024

In recent years, there has been widespread adoption of machine learning (ML) technologies to unravel intricate relationships among diverse parameters in various additive manufacturing (AM) techniques. These ML models excel at recognizing complex patterns from extensive, well-curated datasets, thereby unveiling latent knowledge crucial for informed decision-making during the AM process. The collaborative synergy between and holds potential revolutionize design production AM-printed parts. This review delves into challenges opportunities emerging intersection these two dynamic fields. It provides a comprehensive analysis publication landscape ML-related research field AM, explores common applications (such as quality control, process optimization, microstructure analysis, material formulation), concludes by presenting an outlook that underscores utilization advanced models, development sensors, AM-related Notably, garnered increased attention due its superior performance across applications. is envisioned integration processes will significantly enhance 3D printing capabilities areas.

Language: Английский

Citations

77

Revolutionizing drug formulation development: The increasing impact of machine learning DOI
Zeqing Bao,

Jack Bufton,

Riley J. Hickman

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 202, P. 115108 - 115108

Published: Sept. 27, 2023

Language: Английский

Citations

56

Machine learning using multi-modal data predicts the production of selective laser sintered 3D printed drug products DOI Creative Commons
Youssef Abdalla, Moe Elbadawi,

Mengxuan Ji

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 633, P. 122628 - 122628

Published: Jan. 20, 2023

Three-dimensional (3D) printing is drastically redefining medicine production, offering digital precision and personalized design opportunities. One emerging 3D technology selective laser sintering (SLS), which garnering attention for its high precision, compatibility with a wide range of pharmaceutical materials, including low-solubility compounds. However, the full potential SLS medicines yet to be realized, requiring expertise considerable time-consuming resource-intensive trial-and-error research. Machine learning (ML), subset artificial intelligence, an in silico tool that accomplishing remarkable breakthroughs several sectors ability make highly accurate predictions. Therefore, present study harnessed ML predict printability formulations. Using dataset 170 formulations from 78 models were developed inputs included formulation composition characterization data retrieved Fourier-transformed infrared spectroscopy (FT-IR), X-ray powder diffraction (XRPD) differential scanning calorimetry (DSC). Multiple explored, supervised unsupervised approaches. The results revealed can achieve accuracies, by using leading maximum F1 score 81.9%. FT-IR, XRPD DSC as resulted 84.2%, 81.3%, 80.1%, respectively. A subsequent pipeline was built combine predictions into one consensus model, where found further increase 88.9%. it determined first time benefit multi-modal data, combining numeric, spectral, thermogram data. lays groundwork leveraging existing developing high-performing computational accelerate development.

Language: Английский

Citations

49

3D printing in personalized medicines: A focus on applications of the technology DOI

Pavan Kalyan BG,

Sonal Mehrotra,

Shirleen Miriam Marques

et al.

Materials Today Communications, Journal Year: 2023, Volume and Issue: 35, P. 105875 - 105875

Published: March 27, 2023

Language: Английский

Citations

48

Applications of 3D printing in medicine: A review DOI Creative Commons
Chensong Dong, Marko D. Petrović, Ian J. Davies

et al.

Annals of 3D Printed Medicine, Journal Year: 2024, Volume and Issue: 14, P. 100149 - 100149

Published: Feb. 7, 2024

3D printing, or additive manufacturing, has transformed various industries with its layer-by-layer fabrication approach. In medicine, biofabrication, seen significant advancements, particularly in the creation of patient-specific medical models and custom-made drug tablets. Bioprinting, a key aspect encompasses three approaches: biomimicry, autonomous self-assembly, microtissues, each unique advantages disadvantages. This comprehensive review explores merits limitations these bioprinting approaches outlines main phases entire process: pre-processing, processing, post-processing. By enhancing patients' quality life, reducing healthcare costs, tapping into global device market, biofabrication technologies hold immense promise for future medicine. literature focuses on applications printing creating devices, including bone tissues, joint printed tablets, models.

Language: Английский

Citations

29

Application of 3D printing in early phase development of pharmaceutical solid dosage forms DOI Creative Commons

Rachel Milliken,

Thomas Quinten,

Sune K. Andersen

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 653, P. 123902 - 123902

Published: Feb. 14, 2024

Three-dimensional printing (3DP) is an emerging technology, offering the possibility for development of dose-customized, effective, and safe solid oral dosage forms (SODFs). Although 3DP has great potential, it does come with certain limitations, traditional drug manufacturing platforms remain industry standard. The consensus appears to be that technology expected benefit personalized medicine most, but unlikely replace conventional mass production. method, on other hand, could prove well-suited producing small batches as adaptive technique enabling clinical trial design early studies. purpose this review discuss recent advancements in technologies SODFs focus applications stages, including a discussion current regulatory challenges quality controls.

Language: Английский

Citations

27

3D printing technology: A new approach for the fabrication of personalized and customized pharmaceuticals DOI
Muneeb Ullah, Abdul Wahab, Shahid Ullah Khan

et al.

European Polymer Journal, Journal Year: 2023, Volume and Issue: 195, P. 112240 - 112240

Published: June 20, 2023

Language: Английский

Citations

40