Formation and stabilization mechanism of Ginsenoside Rg3 inclusion complexes based on molecular simulation

Pharmaceutical Development and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 2, 2025

The formation of inclusion complexes between Ginsenoside Rg3 and cyclodextrins represents a promising strategy to enhance the solubility G-Rg3. Nevertheless, molecular mechanisms underlying interaction G-Rg3 have yet be fully elucidated. In this study, we employed combination simulation experimental methodologies identify most effective solubilizing carriers among G-Rg3, β-cyclodextrin (β-CD), 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), 2,6-dimethyl-β-cyclodextrin (DM-β-CD). formed with HP-β-CD demonstrates superior stability water compared those β-CD DM-β-CD. preparation process for was optimized through an orthogonal testing approach. optimal conditions were determined mass ratio 1:125, time 2 h, temperature 30 °C. confirmed using DSC, Fourier Transform Infrared FTIR, XRD techniques. vitro tests indicated that 2.9 times greater than Molecular dynamics (MD) simulations provided insights into stabilize their solubility. primary force identified as van der Waals force.

Language: Английский

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Fabrication, Characterization, and Pharmacokinetics of Phospholipid-Based Naturosomal Nanocarriers for Enhanced Oral Solubility and Bioavailability of Naringin

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 4, 2025

Language: Английский

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A COMPLETE SOJOURN ON NANOTECHNOLOGICAL ADVANCEMENTS AND NANOCARRIERS APPLICATIONS IN ARTHRITIS MANAGEMENT

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106705 - 106705

Published: Feb. 1, 2025

Language: Английский

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Development and preclinical evaluation of a lipomer-based combinatorial delivery system for phytoconstituent and immunosuppressant in the management of Rheumatoid arthritis

Particulate Science And Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: March 15, 2025

Language: Английский

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Development of Etoricoxib loaded mesoporous silica nanoparticles laden gel as vehicle for transdermal delivery: Optimization, ex-vivo permeation, histopathology and in-vivo anti-inflammatory study.

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: April 7, 2025

Etoricoxib (ETB) is a nonsteroidal anti-inflammatory therapeutic agent. It poorly soluble and has various gastrointestinal side effects such as bleeding ulcers after oral administration. The present research aimed to develop an ETB-loaded mesoporous silica nanoparticle-laden gel (ETB-MSNPs) for transdermal delivery improve efficacy. ETB-MSNPs were synthesized using precipitation solvent evaporation technique their optimization was performed Box-Behnken design. optimized incorporated into carbopol-chitosan evaluated in-vitro, ex-vivo, in-vivo activity. displayed nanosize of particles with distribution high entrapment efficiency ETB. FTIR DSC studies showed that ETB encapsulated in MSNPs. successfully integrated the carbopol chitosan gel, which exhibited excellent viscosity spreadability. significantly higher more sustained release compared pure gel. Optimized considerably effect significant reduction IL-1β TNF-α levels histopathological examination confirmed did not exhibit any toxicity on skin. Based findings, results suggest MSNPs potential carrier enhancing efficacy through topical delivery, although further are needed fully confirm its effectiveness.

Language: Английский

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Multiparticulate Drug Delivery of Losartan Potassium via Extrusion-Spheronization: Formulation and Dissolution Comparisons

BIO Integration, Journal Year: 2024, Volume and Issue: 5(1)

Published: Jan. 1, 2024

Abstract Background: Losartan potassium, an antihypertensive medication, has high solubility and a short half-life that result in potential adverse effects rapid drug clearance. Multiparticulate delivery systems enhance the drug’s bioavailability, decrease patient-to-patient variability, optimize distribution. Herein, losartan potassium pellets for sustained release were developed characterized. Methods: The formulation process involved varying concentrations of Eudragit RSPO (200 mg, 400 or 600 mg) L100 across nine pellet batches, adjusting triethyl citrate accordingly. pellets’ bulk density, tapped flow properties (Carr’s index, Hausner’s ratio, angle repose), content, particle size distribution, vitro evaluated. Interactions between excipients analyzed with FTIR DSC. Results: spectra indicated physical interactions without major chemical alterations, whereas DSC thermograms revealed changes thermal behavior due to excipient interactions. In studies formulations higher achieved controlled, prolonged release. optimized batch (F7) demonstrated balanced characteristics including favorable good properties, profile. Varying polymer plasticizer significantly influenced performance, F7 was found be most promising sustained-release applications. Conclusion: This study underscores importance selection optimization developing effective systems, implications enhancing therapeutic outcomes clinical practice.

Language: Английский

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Cabozantinib-phospholipid complex for enhanced solubility, bioavailability, and reduced toxicity in liver cancer

Therapeutic Delivery, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17

Published: Nov. 29, 2024

To enhance the therapeutic potential of Cabozantinib (CBZ), a tyrosine kinase inhibitor with limited water solubility, low bioavailability, and high toxicity, by developing Cabozantinib-Phospholipid Complex (CBZ-PLS).

Language: Английский

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